125,433 research outputs found
In Memoriam : Rudolf B. Schlesinger, 1909-1996
No full textBarcelo John J. In Memoriam : Rudolf B. Schlesinger, 1909-1996. In: Revue internationale de droit comparé. Vol. 49 N°3, Juillet-septembre 1997. pp. 709-713
Corria, Filiberto -- 1977-92 -- Correspondence, Individual -- letter, 1977-12-18
No full textLetter from Gener, Luis Barcelo to Sabin, Albert B. dated 1977-12-18.Sabin Collection Fair Use Policy</a
B. Barcelo-Pons, Evolución reciente y estructural actual de la poblacion en las islas baleares
No full textKolodny Emile. B. Barcelo-Pons, Evolución reciente y estructural actual de la poblacion en las islas baleares. In: Méditerranée, deuxième série, tome 14, 3-1973. pp. 90-92
B. Barcelo-Pons, Evolución reciente y estructural actual de la poblacion en las islas baleares
No full textKolodny Emile. B. Barcelo-Pons, Evolución reciente y estructural actual de la poblacion en las islas baleares. In: Méditerranée, deuxième série, tome 14, 3-1973. pp. 90-92
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Mass propagation for electromagnetic Schrödinger evolutions
No full textWe investigate the validity of Gaussian lower bounds for solutions to an electromagnetic Schrödinger equation with a bounded time-dependent complex electric potential and a time-independent vector magnetic potential. We prove that, if a suitable geometric condition is satisfied by the vector potential, then positive masses inside of a bounded region at a single time propagate outside the region, provided a suitable average in space–time cylinders is taken
Studies on obesity-related dysfunction in insulin-target tissues : insulin receptor isoforms and intraocular in vivo liver imaging
No full textObesity, caused by poor dietary habits and sedentary lifestyle, has brought on a global health crisis. This condition affects over one-third of adults and largely increases the risk of developing metabolic diseases, such as type 2 diabetes and steatotic liver disease. Insulin is a central hormone in regulating metabolism and insulin receptors are ubiquitously expressed. In mammals, the insulin receptor (IR) has two isoforms, IR-A and IR-B, which differ in structure and function and trigger different signalling pathways within the cell. The first half of this thesis focuses on studying the IR isoforms and their role in metabolic dysfunction. Insulin resistance has been associated with variations in IR isoform expression, however, the mechanisms behind tissue/cell type-specific changes in metabolic disease are poorly understood. Using mouse models of obesity/diabetes we report IR isoform expression patterns in different tissues. We further investigated a shift in IR isoform ratio in perigonadal adipose tissue, and found tissue remodeling and immune cells infiltration to be responsible, rather than a change in IR isoform expression in adipocytes. We also worked to identify novel and isoform-specific IR interaction partners, to understand more about the intracellular signalling triggered by the receptors. The second half of this thesis focusses on the liver, a key player in metabolic regulation. The liver is inaccessible for optical imaging and there is a lack of high-resolution non-invasive imaging techniques. Addressing this need, we developed a novel in vivo imaging platform to monitor liver function longitudinally at cellular resolution. We use the anterior chamber of the mouse eye as a transplantation site for liver spheroids, which engraft on the iris. The cornea acts as a natural body window and allows repeated imaging of the same cells over time. We show that the liver spheroids in the eye retain hepatocyte-specific and liver-like features and perform typical hepatic functions. Importantly, we show that in feeding graft-bearing animals an obesogenic diet, the intraocular grafts developed hepatosteatosis, thereby reporting on endogenous liver function. Thus, we foresee this new technology could provide a unique tool to study steatotic liver disease in both basic and pre-clinical settings.List of scientific papersI. Moruzzi, N., Lazzeri-Barcelo, F., Valladolid-Acebes, I., Moede, T., Paschen, M., Leibiger, B., Berggren, P. O., & Leibiger, I. B. (2021). Tissue-specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models. Journal of cellular and molecular medicine. 25(10), 4800–4813. https://doi.org/10.1111/jcmm.16452 II. Lazzeri-Barcelo, F., Leibiger, B., Beusch, C. M., Sabatier, P., Zubarev, R. A., Leibiger, I. B., Berggren, P. O., & Moruzzi, N. BioID-mediated identification of novel IR interaction partners. [Manuscript]III. Lazzeri-Barcelo, F., Oliva-Vilarnau, N., Baniol, M.,Leibiger, B., Bergmann, O., Lauschke, V. M., Leibiger, I. B., Moruzzi, N., & Berggren, P. O. (2024). Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function. Nature communications. 15(1), 767. https://doi.org/10.1038/s41467-024-45122-4 IV. Lazzeri-Barcelo, F., Ciardo, P., Leibiger, B., Leibiger, I. B., Berggren, P. O., & Moruzzi, N. (2024). In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye. J Vis Exp. (205), e66234. https://doi.org/10.3791/66234 </p
On the interactions between multiple overlapping WLANs using channel bonding
No full textNext-generation wireless local area networks (WLANs) will support the use of wider channels, which is known as channel bonding, to achieve higher throughput. However, because both the channel center frequency and the channel width are autonomously selected by each WLAN, the use of wider channels may also increase the competition with other WLANs operating in the same area for the available channel resources. In this paper, we analyze the interactions between a group of neighboring WLANs that use channel bonding and evaluate the impact of those interactions on the achievable throughput. A continuous-time Markov network model that is able to capture the coupled dynamics of a group of overlapping WLANs is introduced and validated. The results show that the use of channel bonding can provide significant performance gains, even in scenarios with a high density of WLANs, although it may also cause unfair situations in which some WLANs receive most of the transmission opportunities while others starve
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
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