1,721,065 research outputs found
Machine Learning Techniques for Context Extraction and User Profiling in 5G Mobile Systems
No full textPharmacokinetic / pharmacodynamic evaluation of marbofloxacin for common pathogens in swine following single intramuscular administration of different doses
Full text linkThe aims of the present work were to study the pharmacokinetics of marbofloxacin 10% solution after single i.m. administration at doses of 6, 8, 10 mg/kg b.w. in swine of 20 weeks of age, to estimate the PK/PD indices using bibliographic MIC90 values and to assess the tolerability of the drug. Marbofloxacin Cmax increased in a dose dependent manner, however animals receiving the 10 mg/kg b.w. dose revealed slightly lower AUCi compared to those receiving 8 mg/kg b.w. This suggests a potential alteration of the elimination mechanisms, evidenced by Cltot values after administration of the three dosages. According to the results of the study, the three tested dosages are well tolerated and active for 2-3 days against the most common pathogens in swine. In particular, 8 mg/kg appeared to be the most suitable dose, since 6 mg/kg might be insufficient against the less susceptible pathogens and 10 mg/kg seemed not to provide any advantage
Raw Data on Propranolol in Pig Plasma
No full textThis dataset supports a study on the pharmacokinetics of propranolol in pig plasma. The study focused on the development and validation of a rapid and sensitive LC-MS/MS method for the simultaneous quantification of propranolol and its metabolite, 4-hydroxypropranolol, in pig plasma and dried blood spots (DBS). The method demonstrated excellent linearity, accuracy, and precision, and its application to a pharmacokinetic study in pigs revealed the absence of 4-hydroxypropranolol, providing new insights into propranolol metabolism in this species
Tolerability and pharmacokinetics of two antimony products after subcutaneous administration in dogs
Full text linkIntroduction: Pentavalent antimony is the first choice drug for leishmaniasis in dog. Leishmaniasis has a complex pathogenesis and it manifests various clinical signs, some of which are often similar to those associated with the toxicity induced by antimonial treatment. Among the reasons for this toxicity, also a general problem of drug’s quality has been reported. Methodology: The general and local tolerability of two commercially available meglumine antimoniate based veterinary products was evaluated in 12 healthy dogs, 6 receiving Antimania (Fatro, Italy) and 6 receiving Glucantime (Merial, Spain), following repeated subcutaneous administrations of therapeutic doses for 14 days. Results: Individual and mean values of haematological and biochemical parameters in both groups remained in the physiological range, with no considerable differences within the two groups. The general tolerability of the drugs was also supported by clinical observations and physical examination of the dogs throughout the whole study period. Only slight local reactions at the injection sites, that spontaneously disappeared, were observed for both products starting from 12-84 hours after the administration. The pharmacokinetic parameters indicated no antimony accumulation. Conclusions: These results suggest that meglumine antimoniate administered at the recommended dosage regimen is well tolerated by healthy dogs, and that there is no significant difference between the two tested products
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A single LC‐MS/MS validated method for tulathromycin quantification in plasma, seminal plasma, and urine to be applied in a pharmacokinetic study in bull
Full text linkTulathromycin is a macrolide antibiotic generally used for the treatment of respiratory diseases in cattle and swine. This work proposes an improvement of a previously published LC‐MS/MS method for tulathromycin determination in pig serum, here validated in three different bull matrices: plasma, seminal plasma, and urine. The approach is based on a quick protein precipitation with acetonitrile, filtration, and sample dilution before injection, allowing to rapidly process large batches of samples. Analytes separation was obtained using a BEH C18 (50 × 2.1 mm, 1.7 μm) column, maintained at 40°C with a chromatographic run of 5 min. The method was fully validated over concentration ranges suitable for field levels of tulathromycin found in each matrix (0.01–1 μg/ml for plasma, 0.05–5 μg/ml for seminal plasma, and 0.1–10 μg/ml for urine), showing good linearity during each day of testing (R (2) always >0.99). Accuracy and precision were within ±15% at all QC concentrations in all the three matrices. Furthermore, the use of tulathromycine‐d7 as internal standard mitigated the potential impacts of matrix effect. The validated technique was successfully applied to samples collected during a pharmacokinetic study in bulls, allowing to monitor tulathromycin concentrations over time in the three matrices. To our knowledge, this is the first validated approach for LC‐MS/MS quantification of tulathromycin in seminal plasma and urine
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Disposition of Stanozolol in Plasma After Intra-articular Administration in the Horse
No full textThe purpose of this study was to provide data on the disposition of stanozolol after bilateral intra-articular injection in the tarsal joints, to discover the length of time for which the drug can be detected in plasma after administration. Fourteen horses were included in the study. After aseptically preparing the injection site, 1 mL of an aqueous suspension containing 5 mg of stanozolol was injected into both the right and left tarsal joints of 12 horses; the two remaining animals were not treated and were used as a control group. Five milliliters of blood was collected immediately before stanozolol administration (t0) and at 1, 2, 4, 6, 12, 18, 24, 36, 48, 60, 72, 84, 96, 108, 120, 132, 144, 156, and 168 hours after injection. The plasma concentration was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) after solid phase extraction. The maximum plasma concentration was 1.7 ng/mL (range, 0.5–3.0 ng/mL), measured at 6 hours (range, 4–12 hours). The plasma elimination half life varied between 4 and 12 hours, whereas the plasma clearance per fraction of dose absorbed was in the 257.85–820.88 L/h range. The results of the present study make a preliminary contribution toward understanding the elimination profile of intra-articularly administered stanozolol in the horse. The drug passes rapidly into the systemic circulation, is eliminated rapidly, and is detected in plasma for no more than 36 hours after local administration
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