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Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells
No full textWidera D, Hauser S, Kaltschmidt C, Kaltschmidt B. Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells. Anatomy Research International. 2012;2012:1-9.Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells
Hjalmar Meissner (1885-1940)
No full textCarl Hjalmar Meissner was born 1 March 1865 in Helsinki, Finland and died 28 May 1940 in Stockholm. He was a Finnish-Swedish pianist, conductor, arranger, composer and author. As a conductor, he worked mainly as a bandleader for military music and theatre ensembles, but also as an opera and symphony orchestra conductor. His profession as a composer arose mostly from his work as pianist and conductor. He was married to operetta singer Emma Meissner in 1899.</p
Observation and control of hybrid spin-wave-Meissner-current transport modes
No full textSuperconductors are materials with zero electrical resistivity and the ability to expel magnetic fields, which is known as the Meissner effect. Their dissipationless diamagnetic response is central to magnetic levitation and circuits such as quantum interference devices. In this work, we used superconducting diamagnetism to shape the magnetic environment governing the transport of spin waves-collective spin excitations in magnets that are promising on-chip signal carriers-in a thin-film magnet. Using diamond-based magnetic imaging, we observed hybridized spin-wave-Meissner-current transport modes with strongly altered, temperature-tunable wavelengths and then demonstrated local control of spin-wave refraction using a focused laser. Our results demonstrate the versatility of superconductor-manipulated spin-wave transport and have potential applications in spin-wave gratings, filters, crystals, and cavities.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QN/vanderSarlabQN/Kavli Nanolab DelftQN/Blanter Grou
The use of the special theory of relativity for the Meissner Effect in superconductor
No full textThe electromagnetic waves are considered in this article as the mediators of interaction in the Meissner Effect or the diamagnetic property of the superconductors. During the cooling of a superconductor electromagnetic waves may be released when the electrons occupy lower states of the energy. These electromagnetic waves may combine in circularly, elliptically and spherically rotating ways, being called in this article the rounded electromagnetic fields. The application of the Lorentz transformation of the Special Theory of Relativity to the magnetic vectors of the mediating electromagnetic fields implies the magnetic orthogoniopedic effect inside the bulk of a superconductor in the Meissner Effect.PhysicsApplied Science
First person – Justyna Meissner
No full textABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Justyna Meissner is the first author on ‘The ARF guanine nucleotide exchange factor GBF1 is targeted to Golgi membranes through a PIP-binding domain’, published in Journal of Cell Science. Justyna is a postdoctoral fellow in the laboratory of Dr Elizabeth Sztul at University of Alabama at Birmingham, USA, investigating the structure and function of large GEFs.</jats:p
StatusDiversity: Methoden der Datenerhebung
No full textIn diesem Teilbericht wird die Entwicklung des innovativen Interviewinstruments digital-narrative- photo-elicitation (DNP) zur Erhebung von Migrations-Status-Geschichten beschrieben. Die im Rahmen des Forschungsprojektes StatusDiversity angelegte Forschung will durch die Rekonstruktion individueller Migrations-Status-Geschichten besser verstehen, wie räumlich und zeitlich differenzierte Muster von legal status diversity entstehen (Meissner 2017). Neben der reinen Entwicklung der DNP wird auch das Vorgehen bei der methodischen Realisierung der Datenerhebung reflektiert, insbesondere der Zugang zu und die Auswahl von InterviewpartnerInnen. Abschließend wird das Vorgehen zur Auswertung der mit Hilfe der DNP gesammelten Daten erläutert.OLD Urban Renewal and Housin
Currency Mismatches, Default Risk, and Exchange Rate Depreciation: Evidence from the End of Bimetallism
No full textIt is generally very difficult to measure the effects of a currency depreciation on a country’s balance sheet and financing costs given the endogenous properties of the exchange rate. History provides at least one natural experiment to test whether an exogenous exchange rate depreciation can be contractionary (via an increased real debt burden) or expansionary (via an improved current account). France’s decision to suspend the free coinage of silver in 1876 played a paramount role in causing a large exogenous depreciation of the nominal exchange rates of all silver standard countries versus gold-backed currencies such as the British pound—the currency in which much of their debt was payable. Our identifying assumption is that France’s decision to end bimetallism was exogenous from the viewpoint of countries on the silver standard. To deal with heterogeneity we implement a difference in differences estimator. Sovereign yield spreads for countries on the silver standard increased in proportion to the potential currency mismatch. Yield spreads for silver countries increased ten to fifteen percent in the wake of the depreciation. Basic growth models suggest that the accompanying reduction in investment could have decreased output per capita by between one and four percent relative to the pre-shock trajectory. This also illustrates that a substantial proportion of the decrease in spreads gold standard countries identified in the “Good Housekeeping” literature could be attributable to the increase in exchange rate stability. Finally, if emerging markets are going to embrace international capital flows, the most export oriented countries will manage to mitigate the negative effects of a currency mismatch.
Currency Mismatches, Default Risk, and Exchange Rate Depreciation: Evidence from the End of Bimetallism
No full textIt is generally very difficult to measure the effects of a currency depreciation on a country%u2019s balance sheet and financing costs given the endogenous properties of the exchange rate. History provides at least one natural experiment to test whether an exogenous exchange rate depreciation can be contractionary (via an increased real debt burden) or expansionary (via an improved current account). France%u2019s decision to suspend the free coinage of silver in 1876 played a paramount role in causing a large exogenous depreciation of the nominal exchange rates of all silver standard countries versus gold-backed currencies such as the British pound%u2014the currency in which much of their debt was payable. Our identifying assumption is that France%u2019s decision to end bimetallism was exogenous from the viewpoint of countries on the silver standard. To deal with heterogeneity we implement a difference in differences estimator. Sovereign yield spreads for countries on the silver standard increased in proportion to the potential currency mismatch. Yield spreads for silver countries increased ten to fifteen percent in the wake of the depreciation. Basic growth models suggest that the accompanying reduction in investment could have decreased output per capita by between one and four percent relative to the pre-shock trajectory. This also illustrates that a substantial proportion of the decrease in spreads gold standard countries identified in the %u201CGood Housekeeping%u201D literature could be attributable to the increase in exchange rate stability. Finally, if emerging markets are going to embrace international capital flows, the most export oriented countries will manage to mitigate the negative effects of a currency mismatch.
Agiles Lernen mit Just-in-Time-Teaching. Adaptive Lehre vor dem Hintergrund von Konstruktivismus und intrinsischer Motivation
No full textAls weitere Dimension in der Betrachtung individueller Voraussetzungen greift der Beitrag von Barbara Meissner und Hans-Jürgen Stenger sowohl konstruktivistische Lernprozessorientierung sowie intrinsische Motivation von Studierenden auf. Der Frage folgend, wie unter Berücksichtigung von Konstruktivismus und Motivation digitale Medien sinnvoll zu einer Öffnung der Hochschulen für heterogene Zielgruppen beitragen können, beleuchten die Autoren den Ansatz des Just-in-Time-Teaching (JiTT). Dieser Ansatz erlaubt flexible, reflexive und durch stetige Evaluation angepasste Lernmöglichkeiten und wird in der Gestaltung der Lernmaterialien den Ansprüchen an motivationale Aspekte gerecht. (DIPF/Orig.
Interleukin 4 and interleukin 10 levels are elevated in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
No full textBackground: In neurodegenerative diseases, increasing attention has been focused on inflammatory mediators such as pro-inflammatory and anti-inflammatory cytokines and their potential influence in the process of neurodegeneration. In prion diseases, much data has been gained on the cell culture and animal disease models level, but only limited information is available on humans affected by Creutzfeldt-Jakob disease (CJD). Objective: To obtain data on anti-inflammatory cytokines interleukin 4 and interleukin 10 in the cerebrospinal fluid of patients with CJD, patients with other dementia, and nondemented neurological patients and controls. Design: Cerebrospinal fluid samples were collected from CJD patients and control subjects, and concentrations of the anti-inflammatory cytokines interleukin 4 and interleukin 10 were determined using an enzyme-linked immunosorbent assay. Patients: Cerebrospinal fluid samples from 61 patients were analyzed. The group was composed of patients with CJD (n = 20), patients with other forms of dementia (n = 10), patients with motoneuron disease (n = 6), patients with normal pressure hydrocephalus (n = 5), and control subjects (n = 20). Conclusions: Elevated levels of the anti-inflammatory cytokines interleukin 4 and interleukin 10 in cerebrospinal fluid of patients with CJD are new findings. The data of the present study provide a clue toward the possible role of cytokines as immunological modifiers in the neurodegenerative process of CJD
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