187,294 research outputs found

    Ansicht der steil aufgerichteten Jura- und Kreideschichten der Gassenstöcke von Zeinenmatt aus

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    A. Baltzer ad nat. del. ; Auf Stein gez. v. P. Brugier ; Ansicht der steil aufgerichteten Jura- und Kreideschichten der Gassenstöcke von Zeinenmatt ausDie Ansicht erschien auch als Illustration in: Richard Armin Baltzer: Der Glärnisch. Ein Problem alpinen Gebirgsbaues. Geologische Monographie über einen Gebirgsstock der ostschweizerischen Kalkalpen. Zürich, Caesar Schmidt (Schabelitz'sche Buchhandlung), 1873, Tafel VI nach S. 100Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SA

    Substrate modulation of the activity of an artificial nanoesterase made of peptide-functionalized gold nanoparticles

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    Nanozymes with a heart of gold: A functional artificial protein has been prepared by grafting a dodecapeptide onto the surface of gold nanoparticles. The system catalyzes the hydrolysis of carboxylate esters and features enzyme-like properties

    Dieter Baltzer, Ezechiel und Deutero- jesaja. Beriihrungen in der Heilserwartung der beiden grossen Exilspropheten.

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    Dieter Baltzer, Ezechiel und Deutero- jesaja. Beriihrungen in der Heilserwartung der beiden grossen Exilspropheten.. In: Syria. Tome 48 fascicule 3-4, 1971. p. 527

    De-novo Metallonucleases Based on Helix-loop-helix Motifs

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    Three new 42-mer peptides (PRI-III) designed to fold into a hairpin helix-loop-helix motif have been prepared. In the peptide sequence two (PRII-III) or four (PRI) copies of an unnatural amino acid bearing a triazacyclononane metal-ion binding site (ATANP) have been inserted in appropriate positions to allow the ligand subunits to face each other either within the same helix or between the two helices of the hairpin motif. Circular dichroism (CD) studies in solution have shown that the apopeptides adopt a well-defined helix-loop-helix tertiary structure that dimerizes in solution at concentrations above 200 pm to form a four-helix bundle. However, the helical content is strongly dependent on pH and metal-ion binding. Both protonation of the amines of the triazacyclononane units present in the ATANP lateral arm and complexation with Zn-II ions cause a significant decrease of the helical content of the sequences. The Zn-II complexes of the three peptides catalyze the transesterification of the RNA model substrate 2-hydroxypropyl-p-nitrophenyl phosphate (HPNP) with different efficiency. The best catalyst appears to be PR I-4Zn(II), that is, the peptide incorporating four ATANP units. Michaelis-Menten saturation kinetics allowed us to estimate that substrate fully bound to the catalyst reacts 380 times faster than in its absence. The kinetic evidence suggests cooperativity between (at least two) metal ions: one activating the nucleophilic species (directly or indirectly) and the other facilitating nucleophilic attack by coordination of the phosphate

    INVIVO STUDY OF THE NUCLEAR-QUADRUPOLE INTERACTION OF 99MO (BETA-99TC IN NITROGENASE OF KLEBSIELLA PNEUMONIAE

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    MOTTNER P, LERF A, NI X, BUTZ T, ERFKAMP J, Müller A. INVIVO STUDY OF THE NUCLEAR-QUADRUPOLE INTERACTION OF 99MO (BETA-99TC IN NITROGENASE OF KLEBSIELLA PNEUMONIAE. In: Hyperfine Interactions. HYPERFINE INTERACTIONS. Vol 61. BALTZER SCI PUBL BV; 1990: 1215-1218

    Dieter Baltzer, Ezechiel und Deutero- jesaja. Beriihrungen in der Heilserwartung der beiden grossen Exilspropheten.

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    Dieter Baltzer, Ezechiel und Deutero- jesaja. Beriihrungen in der Heilserwartung der beiden grossen Exilspropheten.. In: Syria. Tome 48 fascicule 3-4, 1971. p. 527
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