329,204 research outputs found
The effect of competition between two spatially separated markets - An investigation of two interlinked Bak-Sneppen models
No full textThis paper investigates the effect of competition in a market consisting of interlinked economic agents. In particular, the effect of increased competition from the surrounding markets is demonstrated. The presented work is an extension of the Bak-Sneppen model (Bak and Sneppen 1993). Here are two Bak-Sneppen models interlinked such that if the lowest fitness value of one market exceeds the fitness values of the other market minus transportation cost, all cells lower than this band will receive a new random value. The model shows that interdependency between markets has a strong effect on the competitiveness of the least competitive market. The external competition is able to make the least competitive market perform better as well as worse than on its own.Bak-Sneppen model, interdependency, competition, Marketing,
Rank-driven Markov processes
No full textWe study a class of Markovian systems of N elements taking values in [0,1] that evolve in discrete time t via randomized replacement rules based on the ranks of the elements. These rank-driven processes are inspired by variants of the Bak–Sneppen model of evolution, in which the system represents an evolutionary ‘fitness landscape’ and which is famous as a simple model displaying self-organized criticality. Our main results are concerned with long-time large-N asymptotics for the general model in which, at each time step, K randomly chosen elements are discarded and replaced by independent U[0,1] variables, where the ranks of the elements to be replaced are chosen, independently at each time step, according to a distribution κ N on {1,2,…,N} K . Our main results are that, under appropriate conditions on κ N , the system exhibits threshold behavior at s ∗∈[0,1], where s ∗ is a function of κ N , and the marginal distribution of a randomly selected element converges to U[s ∗,1] as t→∞ and N→∞. Of this class of models, results in the literature have previously been given for special cases only, namely the ‘mean-field’ or ‘random neighbor’ Bak–Sneppen model. Our proofs avoid the heuristic arguments of some of the previous work and use Foster–Lyapunov ideas. Our results extend existing results and establish their natural, more general context. We derive some more specialized results for the particular case where K=2. One of our technical tools is a result on convergence of stationary distributions for families of uniformly ergodic Markov chains on increasing state-spaces, which may be of independent interest
‘Literary Journalism gives a voice to the silenced’: An Interview with John S. Bak
No full textComunicação & Sociedade, v. 43, n.1Is it possible to find a single and satisfactory definition of Literary Journalism throughout the world that would suit every writer who dabbles in the genre, convince every editor who publishes it and please every scholar who studies it? This is the question that has preoccuped John S. Bak in his research in the field. One of the founders of the International Association for Literary Journalism Studies (IALJS), Bak believes that every work which considers itself to be Literary Journalism necessarily bears within its very DNA the particular history, culture and society from whence it came. In this interview, conducted via Skype, he talks about the foundation, mission and work of IALJS, the global efforts of Literary Journalism to legitimize itself, and the role the internet and new digital platforms can have in contributing to its success
Quantum information metric on ℝ × S d − 1
No full textAbstract We present a formula for the information metric on ℝ × S d − 1 for a scalar primary operator of integral dimension Δ > d + 1 2 . This formula is checked for various space-time dimensions d and Δ in the field theory side. We check the formula in the gravity side using the holographic setup. We clarify the regularization and renormalization involved in these computations. We also show that the quantum information metric of an exactly marginal operator agrees with the leading order of the interface free energy of the conformal Janus on Euclidean S d , which is checked for d = 2, 3
Witten indices of abelian M5 brane on R X S-5
No full textWitten indices and partition functions are computed for abelian 6d tensor and hypermultiplets on R X S-5 in Lorentzian signature in an R gauge field background which preserves some supersymmetry. We consider a general supersymmetric squashing that also admits squashing of the Hopf fiber. Wick rotation to Euclidean M5 brane amounts to Wick rotation of squashing parameters and the hypermultiplet mass parameter. We compute Casimir energies for tensor and hypermultiplets separately for general squashing, and match these with the corresponding gravitational anomaly polynomials. We extract Witten indices on R X CP2 and find that this is zero, again matching with the vanishing anomaly polynomial on an odd dimensional space.
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A comfort comparison of travoprost BAK-free 0.004% versus latanoprost 0.005% in patients with primary open-angle glaucoma or ocular hypertension
No full textDavid A Godfrey1, Lee S Peplinski2, Jeanette A Stewart3, William C Stewart31Glaucoma Associates of Texas, Dallas, TX, USA; 2Kentuckiana Institute for Eye Research, Louisville, KY, USA; 3PRN Pharmaceutical Research Network, LLC, Dallas, TX, USAPurpose: To determine the short-term comfort after a single dose of travoprost BAK-free compared to latanoprost in primary open-angle glaucoma or ocular hypertensive patients.Design: Prospective, double-masked, randomized comparison of two separate active agents dosed once in opposite eyes.Methods: At Visit 1, qualified patients began a glaucoma medicine-free period for three days. At Visit 2, patients were randomly assigned to travoprost BAK-free or latanoprost in opposite eyes. Following dosing in each eye, patients completed a visual analog scale (VAS score, 0–100 mm) at specified time intervals and a comfort survey.Results: In 54 completed subjects, no difference existed five seconds after dosing, in comfort on the VAS between latanoprost (7.1 ± 16.2 mm) and travoprost BAK-free (7.8 ± 16.1 mm, P = 0.53). Also no differences existed between treatments following dosing for discomfort at individual timepoints past five seconds, peak discomfort or the time required to return to baseline comfort (P > 0.05). In addition, the comfort survey demonstrated no difference between products for burning, stinging, foreign body sensation, overall comfort and general acceptance between the products, both for absolute levels and changes from baseline (P > 0.05).Conclusion: Following a single instillation, both latanoprost and travoprost BAK-free exhibit similar comfort scores.Keywords: comfort, travoprost BAK-free, latanoprost, glaucoma, ocular hypertensio
Verdwijning en verandering: beeldvorming en boodschappen in Edward S. Curtis' The North American Indian
No full textContains fulltext :
155913.pdf (Publisher’s version ) (Open Access)Radboud Universiteit, 11 maart 2016Promotores : Bak, J.T.J., Rietbergen, P.J.A.N.517 p
Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
No full textBAK and BAX, which drive commitment to apoptosis, are activated principally by certain BH3-only proteins that bind them and trigger major rearrangements. One crucial conformation change is exposure of their BH3 domain which allows BAK or BAX to form homodimers, and potentially to autoactivate other BAK and BAX molecules to ensure robust pore formation and cell death. Here, we test whether full-length BAK or mitochondrial BAX that are specifically activated by antibodies can then activate other BAK or BAX molecules. We found that antibody-activated BAK efficiently activated BAK as well as mitochondrial or cytosolic BAX, but antibody-activated BAX unexpectedly proved a poor activator. Notably, autoactivation by BAK involved transient interactions, as BAK and BAX molecules it activated could dissociate and homodimerize. The results suggest that BAK-driven autoactivation may play a substantial role in apoptosis, including recruitment of BAX to the mitochondria. Hence, directly targeting BAK rather than BAX may prove particularly effective in inhibiting unwanted apoptosis, or alternatively, inducing apoptosis in cancer cells
SISTEM MONITORING BAK AIR SECARA REALTIME BERBASIS INTERNET OF THINGS
No full textSISTEM MONITORING BAK AIR SECARAREALTIME BERBASIS INTERNET OF THINGS Wahyu Indah Amalia Program StudiTeknikInformatika, UniversitasYudhartaPasuruan Air sangat di butuhkan oleh manusia untuk mandi, minum, mencuci dan kebutuhan lainnya. Masalah utama yang terjadi untuk sumber daya air meliputi penggunaan air yang berlebihan yang akhi ya membuat pengeluaran bulanan menjadi membengkak. Oleh karena itu dibuatlah sistem monitoring bak air yang memanfaatkan NodeMCU, Sensor Water Level sebagai pembaca ketinggian bak air, dan Sensor Turbidity sebagai pembaca kekeruhan air yang nanti ditampilkan pada aplikasi yang diakses melalui smartphone android. Dengan adanya sistem tersebut masyarakat dapat memantau ketinggian dan kekeruhan air secara realtime. Sehingga dapat mengurangi pemborosan dan sumber daya air tetap terjaga
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