102,987 research outputs found

    Rhabdomyoma of the vagina.

    No full text
    Ann Pathol. 2012 Feb;32(1):53-7. Epub 2012 Jan 14. [Rhabdomyoma of the vagina. Case report and short literature review]. Patrelli TS, Franchi L, Gizzo S, Kiener A, Berretta R, Piantelli G, Caruana P, Battista Nardelli G, Bacchi Modena A. SourceUniversità degli Studi di Parma, Clinica Ginecologica ed Ostetrica, Parma, Italie. Abstract The differential diagnosis of vaginal polypoid masses should take rhabdomyoma into consideration even it is an extremely rare tumor. The present report describes a vaginal cystic mass located in the anterior wall of an asymptomatic, 38-year-old, Caucasian, nulliparous woman. Local excision and subsequent pathological examination were performed. The final diagnosis was vaginal rhabdomyoma. The literature is reviewed and differential diagnosis are discussed

    A VALIDATED HPLC METHOD WITH ELECTROCHEMICAL DETECTION FOR SIMULTANEOUS ASSAY OF 5-AMINOSALICYLIC ACID AND ITS METABOLITE IN HUMAN PLASMA

    No full text
    A high-performance liquid chromatographic method was developed, validated and applied to the simultaneous determination of 5-aminosalicylic acid (5-ASA) and its acetylated metabolite (acetyl-5-ASA) in human plasma. The method involves liquid–liquid extraction with methanol followed by isocratic reversed-phase chromatography on a Kromasil KR100 C18 column with electrochemical detection. The recovery, selectivity, linearity, precision and accuracy of the method were evaluated from spiked human plasma samples. The effects of mobile phase composition, buffer concentration, mobile phase pH and concentration of organic modifiers on retention of 5-ASA, acetyl 5-ASA and internal standard were investigated. Limits’ of detection were 5 ng/ mL for 5-ASA and 10 ng/mL for acetyl-5-ASA, respectively. The method can be used for supporting therapeutical drug monitoring and pharmacokinetic studies
    corecore