282 research outputs found

    Replication Data for: Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength

    No full text
    Replication Data for: Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strengt

    O contrato social de Thomas Hobbes: alcances e limites

    No full text
    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em FilosofiaO problema em questão diz respeito ao contrato que funda e legitima o Estado em Thomas Hobbes. Tendo como escopo questionar a possibilidade e/ou impossibilidade de nulidade do contrato social e assim verificar as implicações disto para o conceito de soberania hobbesiana. A leitura que impera na tradição de estudiosos da obra política de Hobbes, em especial do Leviathan, é a de um Estado no qual a soberania é absoluta e irrevogável. A interpretação do contrato firmado entre e, somente, entre os homens, deixando, portanto, o soberano de fora, ofereceria legitimidade a este para agir de forma absoluta e obrigaria ao súdito a obedecer de forma irrestrita. A hipótese que se busca sustentar remete à possibilidade de rompimento, desobediência e mais centralmente da nulidade contratual a partir do vício e/ou desrespeito de determinadas cláusulas fundamentais do contrato, visto se oporem às condições de validade do contrato social. Se isso puder ser sustentado desse modo, isto é, se Hobbes compartilhar mesmo de uma teoria forte da nulidade contratual e pela razão, como declinado acima, que achamos ser a correta, então, tal formulação implicaria em sua teoria uma reconsideração do conceito de soberania e obediência, haja vista o estabelecimento de certos vínculos fortes que condicionam as possibilidades de exigência, autoridade e poder da soberania. Portanto, concentra-se em encontrar uma explicação e/ou teorização da nulidade do contrato social e da sua consequência para a teoria da soberania e obediência hobbesiana

    Semelhança e morte: máscaras mortuárias em Mallarmé e Blanchot

    No full text
    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2014.Esta tese de doutorado em Literatura analisa a imagem e a semelhança como condições essenciais na experiência literária de Stéphane Mallarmé e Maurice Blanchot, mais especificamente nas obras Igitur e Thomas l'Obscur, procurando compreendê-las como máscaras mortuárias na literatura, fato esse permitido pela noção blanchotiana de "meio absoluto", relacionado ao devir-imagem da linguagem na literatura.Résumé : Cette thèse de doctorat en littérature analyse lrimage et la ressemblance comme des conditions essentiels dans lrexpérience littéraire de Stéphane Mallarmé et Maurice Blanchot, surtout dans les oeuvres Igitur et Thomas l?Obscur, en essayant de comprendre les masques mortuaires dans la littérature, ce qui est permis par la notion blanchotienne de Rmilieu absolur, par rapport au devenir-image du langage dans la littérature

    The concept of enmity in the political philosophy of Hobbes

    No full text
    To the author’s knowledge, this is the first systematic study of the concept of enmity in the political philosophy of Thomas Hobbes. Examining this important category does not only elucidate the concept itself, but also provides an opportunity to reconnect fragments of Hobbes’s thought that are increasingly being treated as disparate subjects. It is suggested that the notion of enmity can shed further light on related aspects of his political philosophy, including human competitiveness, the roles of fear and trust, the evil of violent death, the status of rebels, and his theory of international relations. In addition, the subject invites a rethinking of Hobbes’s place in the history of political thought. It is argued that he was among the first to make enmity a central subject of political philosophy. This seems to be related to Hobbes’s break with the traditional notion of natural sociability, as a consequence of which he describes the natural condition of mankind as a war of all against all. Although Hobbes depicts human beings as natural enemies, he holds that enmity does not exclude the possibility of reconciliation; individuals can supposedly overcome their hostility through subjection to a sovereign. These views give rise to a dynamic distinction between public and private enmity, according to which outright hostility can be transformed into private rivalry if human beings renounce their natural right of war. Conversely, subjects become public enemies if they rebel against the sovereign. Hobbes’s views on natural enmity and reconciliation also have important implications for his theory of international relations. This thesis particularly highlights the possibility that states can be decomposed and reassembled after a foreign invasion, which precludes wars of annihilation

    Thomas Nashe's anatomy of Venice in the unfortunate traveller or the life of Jack Wilton (1594): Utopia revisited

    No full text
    International audienceAlthough most critics have focused on the overall negative aspect of Jack Wilton's Italian tour in The Unfortunate Traveller (1594), as suggested in the title of Thomas Nashe's prose fiction, the specificity of the narrator's Venetian adventures should be examined more closely. This paper argues that Thomas Nashe's representation of Venice needs to be reassessed in the context of Thomas More's Utopia and the question of the ideal commonwealth. Notwithstanding Nashe's reliance on pervasive irony, the author provides an image of the city-state which - thanks to a retrospective approach - puts the topic of alternative urban spaces in the early modern period into perspective

    The moneychanger and his wife: from scholastics to accounting

    No full text
    El cambista y su mujer es un cuadro de la escuela flamenca, de principios del siglo XVI, ampliamente utilizado para ilustrar la actividad económica. Existen dos versiones: una de Quentin Massys, 1514, y otra de Marinus van Reymerswaele, 1539, con cambios relevantes entre ambas. Estos cambios tienen un significado económico importante. Las interpretaciones de este cuadro y otros similares que hacen los historiadores del arte son coherentes con su visión del mundo de la economía, más que responder a un análisis objetivo del cuadro y de la historia. Así, mientras que la imagen muestra la actividad comercial y financiera como una profesión normal y respetable, la mayoría de los historiadores del arte consideran que tiene una intención satírica y moralizante. Mi conclusión es que los prejuicios de los historiadores del arte hacia la actividad comercial y financiera les conducen a una interpretación equivocada del cuadro.The Moneychanger and his Wife is a Flemish painting from the early 16th century, widely used to illustrate economic activity. There are two different versions: one by Quentin Massys, 1514, and another by Marinus van Reymerswaele, 1539. There are significant changes between the two versions, which I will argue do have an economic meaning. In the process of reviewing the different interpretations provided by art historians of this picture and other similar ones, we shall see that they are consistent with the views that most art historians share about the commercial and financial world rather than based on any objective interpretation of the painting and history. Thus, while the picture shows commercial and financial activity to be a normal, respectable occupation, most art historians see a moralizing and satirical intention. My view is that art historians’ prejudice towards commercial and financial activity leads them to a wrong interpretation of the painting.

    Quentin Skinner e a interpretação do pensamento político de Thomas Hobbes: uma análise da teoria e da prática do contextualismo linguístico

    No full text
    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em História, Florianópolis, 2024..A presente tese apresenta uma avaliação sobre a aplicação da metodologia de Quentin Skinner para a historiografia, usualmente denominada contextualismo linguístico, por meio dos principais textos produzidos pelo autor acerca do pensamento político de Thomas Hobbes. A contribuição historiográfica de Skinner, tanto para a teoria da história quanto para a história do pensamento político, foi iniciada em meados da década de 1960, momento em que o autor publicou os seus primeiros artigos sobre o contexto político de Hobbes, em paralelo a um ensaio teórico sobre o problema da explicação histórica. A partir daí, Skinner se dedicou a um projeto duplo e interconectado: minar a base das interpretações contemporâneas dos pensadores clássicos da teoria política moderna e, ao mesmo tempo, propor o método de análise adequado para a condução de pesquisas na área. É certo que os trabalhos de Skinner em história do pensamento político não se limitam à análise da obra de Hobbes, assim como seus textos de caráter teórico-metodológico não se restringem exclusivamente ao desenvolvimento do contextualismo linguístico. Todavia, o fato de serem os dois tópicos mais extensamente explorados pelo autor, além de terem surgido de forma paralela, indicam que os seus escritos sobre Hobbes constituem o local privilegiado para uma avaliação, a nível prático, das suas concepções metodológicas. Sendo assim, a proposta geral da tese é ler os textos de Skinner sobre Hobbes como aplicações do contextualismo linguístico e, com isso, esclarecer os méritos e as limitações da metodologia, bem como os resultados que podem ser esperados com a sua utilização, além de sugerir possibilidades de avanços teóricos com base nos debates contemporâneos da historiografia.Abstract: This thesis presents an assessment of the application of Quentin Skinner's methodology to historiography, usually called linguistic contextualism, through the main texts produced by the author about the political thought of Thomas Hobbes. Skinner's historiographical contribution, both to the theory of history and to the history of political thought, began in the mid-1960s, when he published his first articles on Hobbes' political context, in parallel with a theoretical essay on the problem of historical explanation. From then on, Skinner devoted himself to a double and interconnected project: to undermine the basis of contemporary interpretations of the classical thinkers of modern political theory and, at the same time, to propose the appropriate method of analysis for conducting research in the area. It is true that Skinner's work in the history of political thought is not limited to the analysis of Hobbes' work, just as his theoretical-methodological texts are not restricted exclusively to the development of linguistic contextualism. However, the fact that they are the two topics most extensively explored by the author, as well as having arisen in parallel, indicates that his writings on Hobbes constitute the privileged place for an evaluation, at a practical level, of his methodological conceptions. Thus, the general purpose of the thesis is to read Skinner's texts on Hobbes as applications of linguistic contextualism and, thereby, to clarify the merits and limitations of the methodology, as well as the results that can be expected from its use, in addition to suggesting possibilities for theoretical advances based on contemporary debates in historiography

    Agricultural extension - generic challenges and the ingredients for solutions

    No full text
    Is agricultural extension in developing countries up to the task of providing the information, ideas, and organization needed to meet food needs? What role should governments play in implementing or facilitating extension services? Roughly 80 percent of the world's extension is publicly funded and delivered by civil servants, providing a range of services to the farming population, commercial producers, and disadvantaged target groups. Budgetary constraints and concerns about performance create pressure to show the payoff on investment in extension and to explore alternatives to publicly providing it. The authors analyze the challenges facing policymakers who must decide what role governments should play in implementing or facilitating extension services. Focusing on developing country experience, they identify generic challenges that make it difficult to organize extension: a) The magnitude of the task. b) Dependence on wider policy and other agency functions. c) Problems in identifying the cause and effect needed to enable accountability and to get political support and funding. d) Liability for public service functions beyond the transfer of agricultural knowledge and information. e) Fiscal sustainability. f) Inadequate interaction with knowledge generators. The authors show how various extension approaches were developed in attempts to overcome the challenges of extension: 1) Improving extension management. 2) Decentralizing. 3) Focusing on single commodities. 4) Providing free-for-service public extension services. 5) Establishing institutional pluralism. 6) Empowering people by using participatory approaches. 7) Using appropriate media. Each of the approaches has weaknesses and strengths, and in their analysis the authors identify the ingredients that show promise. Rural people know when something is relevant and effective. The aspects of agricultural extension services that tend to be inherently low cost and build reciprocal, mutually trusting relationships are those most likely to produce commitment, accountability, political support, fiscal sustainability, and the kinds of effective interaction that generate knowledge.ICT Policy and Strategies,Decentralization,Enterprise Development&Reform,Agricultural Knowledge&Information Systems,Agricultural Research,Environmental Economics&Policies,Health Monitoring&Evaluation,Agricultural Knowledge&Information Systems,ICT Policy and Strategies,Agricultural Research

    Defender: the life of Daniel H. Wells

    No full text
    Includes bibliographical references and index.Defender is the first and only scholarly biography of Daniel H. Wells, one of the important yet historically neglected leaders among the nineteenth-century Mormons—leaders like Heber C. Kimball, George Q. Cannon, and Jedediah M. Grant. An adult convert to the Mormon faith during the Mormons’ Nauvoo period, Wells developed relationships with men at the highest levels of the church hierarchy, emigrated to Utah with the Mormon pioneers, and served in a series of influential posts in both church and state. Wells was known especially as a military leader in both Nauvoo and Utah—he led the territorial militia in four Indian conflicts and a confrontation with the US Army (the Utah War). But he was also the territorial attorney general and obtained title to all the land in Salt Lake City from the federal government during his tenure as the mayor of Salt Lake City. He was Second Counselor to Brigham Young in the LDS Church's First Presidency and twice served as president of the Mormon European mission. Among these and other accomplishments, he ran businesses in lumbering, coal mining, manufacturing, and gas production; developed roads, ferries, railroads, and public buildings; and presided over a family of seven wives and thirty-seven children. Wells witnessed and influenced a wide range of consequential events that shaped the culture, politics, and society of Utah in the latter half of the nineteenth century. Using research from relevant collections, sources in public records, references to Wells in the Joseph Smith papers, other contemporaneous journals and letters, and the writings of Brigham Young, Quentin Thomas Wells has created a serious and significant contribution to Mormon history scholarship.--Provided by publisher.1634-1814, a Puritan family's progress: the Wells' migration from England to America -- 1814-1838, Daniel H. Wells: from a brief childhood in New York to frontier life in Illinois -- 1839-1841, a bachelor farmer in commerce becomes a married entrepreneur and civic leader in Nauvoo -- 1841-1844, the Mormon hegemony: civic controversy, court cases and family conflict -- 1843-1846, the Mormon hegemony: disaffection and libel leads to mayhem and murder -- 1844-1846, the decline of Nauvoo: Daniel becomes a Mormon and leads in the battle of Nauvoo -- 1846-1848, the cost of conversion: travels to winter quarters and the trail to great Salt Lake City -- 1848-1851, desert home and new callings: the superintendent, the general and the attorney general -- 1851-1855, six additional wives: a dozen children and many enterprises to support the family -- 1855-1857, fighting Indians or feeding them: family matters and Brigham's new counselor -- 1857-1858, the Utah Expedition: causes and consequences, a war of lies and egos, but no casualties -- 1858-1859, the Peace Commission and war by other means: church, territorial and federal politics in Utah -- 1860-1864, family, business, church, and politics in Utah while the Civil War ravages the nation -- 1860-1864, the Wells family grows and prospers during the Civil War -- 1864-1865, Daniel's first (incomplete) term as European Mission president -- 1865-1868, Utah's Black Hawk War -- 1868-1870, mayor of Salt Lake City: defending the faith, fighting crime, and obtaining the deed to the city -- 1870-1878, Mormon versus gentile in railroads, business, government and religion -- 1875-1878, Daniel opposes the Glu, defends Brigham, escapes drowning and dedicates a temple -- 1877-1879, from counselor to assistant, trapped in court, imprisoned and paraded home -- 1880-1885, Wells family marriages, the anti-polygamy crusade, and a second mission in Europe -- 1886-1888, defending against opposition in England while tragedy unfolds at home -- 1887-1891, preparing for his passing, president of the temple, death while still in harness -- Appendix A: the Wells family in England and America, 1484-1814 -- Appendix B: the Chapin family in England and America,1484-1814

    American Writers in Paris

    No full text
    On Baldwin\u27s engagement with Paris during his expatriate period, drawing on essays from Notes of a Native Son (1955) and elsewhere. Miller addresses the role of Baldwin\u27s literary predecessors, including Hemingway, remarking on the younger author\u27s awareness of the Hemingway aura pervading Paris and habit of frequenting some of Hemingway\u27s favorite cafés and bars
    corecore