1,720,994 research outputs found
Stella Mosimann F. 2018, L’anfiteatro, in J. Bonetto, G. Bejor, S.F. Bondì, B.M. Giannattasio, M. Giuman, C. Tronchetti (a cura di), Nora. Sardegna archeologica. Guide e Itinerari, 1, p. 114.
No full textL’iscrizione dallo scavo di San Basilio e i collegi professionali di Adria. Una nota preliminare
No full textSi presenta un'iscrizione inedita, rinvenuta nel corsio degli scavi condotti in località San Basilio (Ariano Polesine, Rovigo), che ricorda l'istituzione di una fondazione funeraria a favore di un collegio professional
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Low exhaled NO in school-age children with bronchopulmonary dysplasia and airflow limitation
No full textBronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, may be associated with long-term airflow limitation. Survivors of BPD may develop asthma-like symptoms in childhood, with a variable response to beta(2)-agonists. However, the pathologic pathways underlying these respiratory manifestations are still unknown. The aim of this study was to measure exhaled nitric oxide (FE(NO)) and lung function in a group of 31 school-age survivors of BPD. They showed variable degrees of airflow obstruction (mean FEV(1) 77.8 +/- 2.3% predicted) unresponsive to beta(2)-agonists in 72% of the subjects. Their FE(NO) values (geometric mean [95% confidence interval]: 7.7 [+/- 1.1] ppb) were significantly lower than in a group of healthy matched control subjects born at term (10.7 [+/- 1.1] ppb, p < 0.05) and a group of preterm children without BPD (9.9 [+/- 1.1] ppb, p < 0.05). The children with BPD were also compared with a group of 31 patients with asthma with a comparable airflow limitation (FEV(1) 80.2 +/- 2.1% predicted) and showed FE(NO) values four times lower than in those with asthma (24.9 [+/- 1.2] ppb, p < 0.001). In conclusion, unlike children with asthma, school-age survivors of BPD have airflow limitation associated with low FE(NO) values and lack of reversibility to beta(2)-agonists, probably as a result of mechanisms related to early life structural changes in the airways
Childhood Course of Lung Function in Survivors of Bronchopulmonary Dysplasia
No full textBronchopulmonary dysplasia (BPD) is the primary respiratory complication of premature birth, associated with a reduced maximal lung function that may carry a risk of a chronic obstructive pulmonary disease (COPD)–like phenotype developing later in life. We demonstrated that severe early airflow obstruction at 2 years identified survivors of BPD at greater risk of disrupted lung growth during their childhood, suggesting a guarded long-term respiratory prognosis. Patients with better airflow at 2 years showed an improvement in lung function in later childhood, suggesting some degree of functional recovery
Exhaled nitric oxide in children with asthma and sinusitis
No full textExhaled nitric oxide (FE(NO)) is a surrogate marker of eosinophilic airway inflammation. The measurement of this gas can be easily performed in children and the result is immediately available. Because of these characteristics, measurement of FE(NO) is slowly becoming part of the routine clinical evaluation of an asthmatic patient. FE(NO) measurement may have a role both in the diagnosis of asthma and as a guide in therapy algorithms. For example when FE(NO) levels are persistently normal and the asthmatic child is asymptomatic, the steroid therapy may be decreased or even stopped. In patients with acute or chronic rhinosinusitis the levels of nasal nitric oxide (nNO) are significantly decreased, while they rise up after a course of antibiotics. The measurement of nasal NO has been proposed as a functional test to evaluate sinus ventilation. Nasal NO is significantly reduced also in primary ciliary dyskinesia and can be used as a screening tool to identify patients affected by this condition
Evidence of unexpected oxidative stress in airways of adolescents born very preterm.
No full textPrematurity and its main respiratory complication, bronchopulmonary dysplasia (BPD), are potentially associated with lifelong respiratory morbidities and/or lung function abnormalities. The mechanisms behind these long-term respiratory problems are still unclear.
We assessed airway oxidative stress in adolescents born very preterm (≤ 32 gestational weeks) by measuring 8-isoprostane concentration in the exhaled breath condensate (EBC). In addition, the study protocol included spirometry and measuring nitric oxide in the exhaled air (FeNO).
The study groups included 34 ex-preterm adolescents with BPD, 18 ex-preterm adolescents without BPD, and 34 healthy controls born at term.
Regardless of a history of BPD, the ex-premature adolescents had higher EBC 8-isoprostane levels [BPD: 9.5(7.3–12.2); preterm non-BPD: 10(8.1–16) pg·mL−1)] than the controls [3.2(1.9–6.5) pg·mL−1] (p<0.001). FEV1 was lower in the BPD group [Z-score:−2.1(1.58)] than in the preterm non-BPD individuals [−1.13(1.15)], who showed in turn significantly lower values than the controls [0.18(0.83); p<0.001]. FeNO was similar in the 3 groups (p=0.55).
Our data show that, after premature birth, evidence of oxidative stress in the airways may be detected into adolescence, suggesting that long-term respiratory abnormalities after preterm birth may be associated with an ongoing airway disease and not just a stabilized structural lung damage
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