1,720,964 research outputs found
Author's reply to "Comment on: Cigarette smoking and appendectomy: Effect on clinical course of diverticulosis"
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Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients
No full textBackground. Both coeliac disease and irritable bowel syndrome show impaired health-related quality of life, however, the impact of
irritable bowel syndrome-type symptoms on health-related quality of life in coeliac disease is unclear.
Aim. To evaluate the effect of gluten-free diet adherence and irritable bowel syndrome-type symptoms co-morbidity on health-related
quality of life in adult coeliac disease patients.
Patients and methods. A total of 1130 adults were enrolled in the study comprising 1001 controls from the general population and 129
diagnosed coeliac disease patients from the University Clinic in Cagliari. Irritable bowel syndrome-type symptoms and health-related quality
of life were assessed using the Rome II and the SF-36 questionnaires, respectively.
Results. Irritable bowel syndrome-type symptoms prevalence in controls was 10.1% (102/1001) and 55% (71/129) in the coeliac disease
patients. Irritable bowel syndrome-type symptom controls and coeliac disease patients both presented significantly lower health-related quality
of life (p≤0.05) compared to healthy controls. Strict diet coeliac disease patients, compared to partial diet patients, showed significantly
(p≤0.05) better scores in all domains, except physical functioning, physical-role and bodily pain.
The lowest scores were found in partial diet coeliac disease patients with irritable bowel syndrome-type symptoms.
Conclusions. The present results confirm the burden of irritable bowel syndrome-type symptoms and coeliac disease on health-related
quality of life. Moreover, these data show that health-related quality of life in coeliac disease is impaired by poor compliance and by
co-morbidity with irritable bowel syndrome-type symptoms
Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients.
No full textBoth coeliac disease and irritable bowel syndrome show impaired health-related quality of life, however, the impact of irritable bowel syndrome-type symptoms on health-related quality of life in coeliac disease is unclear. AIM: To evaluate the effect of gluten-free diet adherence and irritable bowel syndrome-type symptoms co-morbidity on health-related quality of life in adult coeliac disease patients. PATIENTS AND METHODS: A total of 1130 adults were enrolled in the study comprising 1001 controls from the general population and 129 diagnosed coeliac disease patients from the University Clinic in Cagliari. Irritable bowel syndrome-type symptoms and health-related quality of life were assessed using the Rome II and the SF-36 questionnaires, respectively. RESULTS: Irritable bowel syndrome-type symptoms prevalence in controls was 10.1% (102/1001) and 55% (71/129) in the coeliac disease patients. Irritable bowel syndrome-type symptom controls and coeliac disease patients both presented significantly lower health-related quality of life (p<or=0.05) compared to healthy controls. Strict diet coeliac disease patients, compared to partial diet patients, showed significantly (p<or=0.05) better scores in all domains, except physical functioning, physical-role and bodily pain. The lowest scores were found in partial diet coeliac disease patients with irritable bowel syndrome-type symptoms. CONCLUSIONS: The present results confirm the burden of irritable bowel syndrome-type symptoms and coeliac disease on health-related quality of life. Moreover, these data show that health-related quality of life in coeliac disease is impaired by poor compliance and by co-morbidity with irritable bowel syndrome-type symptoms
Effect of gluten-free diet on preventing recurrence of gastroesophageal reflux disease-related symptoms in adult celiac patients with nonerosive reflux disease
No full textBackground and Aim: In Celiac Disease (CD) the role of a gluten-free diet (GFD) on
gastroesophageal reflux disease–related symptoms (GERD-rs) is unclear. The aim of this
study was to establish the recurrence of GERD-rs, in CD patients with nonerosive reflux
disease (NERD).
Methods: From a total of 105 adult CD patients observed, 29 who presented with the
NERD form were enrolled in the study. Thirty non-CD patients with NERD were studied
as controls. Recurrence of GERD-rs was clinically assessed at 6, 12, 18, and 24 months
follow-up (FU) after withdrawal of initial proton-pump inhibitor (PPI) treatment for
8 weeks.
Results: GERD-rs were resolved in 25 (86.2%) CD patients and in 20 (66.7%) controls
after 8 weeks of PPI treatment. In the CD group, recurrence of GERD-rs was found in five
cases (20%) at 6 months but in none at 12, 18, and 24 months while in the control group
recurrence was found in six of 20 controls (30%), in another six (12/20, 60%), in another
three (15/20, 75%), and in another two (17/20, 85%) at 6, 12, 18, and 24 months FU
respectively.
Conclusions: The present study is the first to have evaluated the effect of a GFD in the
nonerosive form of GERD in CD patients, by means of clinical long-term follow-up,
suggesting that GFD could be a useful approach in reducing GERD symptoms and in the
prevention of recurrence
Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity
No full textObjective: To evaluate the association between celiac disease and specific anxiety and depressive disorders and to identify potential common pathogenetic links, with particular regard to thyroid function and autoimmunity. Methods: Cases included 36 adult celiac patients, 25 females and 11 males, aged 18-64 years. Controls comprised 144 healthy subjects matched by sex and age with no clinical evidence or family history of celiac disease. Diagnosis of celiac disease was made on the basis of clinical history and serological criteria. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview, according to DSM-IV criteria. Thyroid was evaluated by palpation, echography and measurement of serum-free thyroid hormones (FT4, FT3), thyroid-stimulating hormone (TSH) and antithyroid autoantibodies (anti-TPO). Results: Compared to controls, a significantly higher number of celiac patients met criteria for lifetime [15 (41.7%) versus 30 (29.8%), P<.01] and 6-month [7 (19.4%) versus 9 (6.2%), OR=3.2, X-2=5.2, P<.05] major depressive disorder (MDD) and lifetime [5 (13.9%) versus 3 (2.1%), P<.001] and 6-month [3 (8.1%) versus 2 (1.4%), P<.05] panic disorder (PD). Anti-TPO prevalence was significantly higher in celiac patients than in the control group (11/36=30.5% versus 14/144=9.7%, P<.001). A higher frequency of PD and MDD was found in celiac patients with positive anti-TPO when compared to negative anti-TPO patients (4/11=36.4% PD in TPO+ versus 1/25=4% PD in TPO-, P<.01; 9/11=81.8% MD in TPO+ versus 6/25=9.5%MD in TPO-,P<.01). Conclusion: Patients affected by celiac disease tend to show a high prevalence of PD and MDD and association with subclinical thyroid disease appears to represent a significant risk factor for these psychiatric disorders. (C) 2002 Elsevier Science Inc. All rights reserved
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Frontal cortical perfusion abnormalities related to gluten intake and associated autoimmune disease in adult celiac disease
No full textPrevalence of irritable bowel syndrome in Italian rural and urban areas
No full textBackground/aims: No comparative studies are available, as yet, in Italy, concerning the prevalence of irritable
bowel syndrome (IBS) in urban and rural areas. The aim is to compare the prevalence of IBS in Italian urban
and rural areas.
Methods: 950 subjects were randomly selected from each area and completed a questionnaire regarding
demographic data and the Rome II questionnaire.
Results: The prevalence of IBS was significantly (pb0.05) higher in the urban (9.9%), than in the rural area (4.4%).
In the urban area, a significantly higher prevalence of IBSwas observed in females than inmales, 67/490 (13.7%)
vs 27/460 (5.9%) (pb0.05), while no gender differences were present in the rural population.
Conclusion: In the urban area, we found a higher prevalence of IBS, and a significantly higher prevalence of IBS in
females than in males, while no gender differences were present in the rural populati
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