1,721,011 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A direct comparison between membrane adsorber and packed column chromatography performance
Full text linkThe purpose of this work was to compare side by side the performance of packed bed and membrane chromatography adsorption processes for protein purification. The comparison was performed using anion exchange media with the same ligand immobilized on the adsorbing surface, namely the strong Q quaternary ammonium group, R-CH2-N+-(CH3)3, and bovine serum albumin (BSA) as a model protein. In addition, the stationary phase volume was held constant for each geometry (3 mL) and runs were executed using the same mobile phase superficial velocity. As expected, the packed bed column showed higher equilibrium binding of BSA at 66.9 mg/mL versus 43.04 mg/mL for the membrane adsorber. Dynamic binding capacities were also higher in the packed bed; for example, at 97.5 cm/h, a capacity of 62.8 mg/mL was measured for the packed bed versus 20.7 mg/mL for the membrane adsorber. The higher equilibrium and dynamic capacities of the packed bed are likely due to the higher surface area per unit volume of the resin. However, the maximum productivity for the membrane adsorber was 111 mg/(mL h), a value that was 3.3 times higher than the one of the packed column. The bed utilization - defined as the ratio of the dynamic binding capacity at 10% breakthrough to the saturation binding capacity - was also higher for the packed column at long residence times and lower at short residence times confirming the better performance of membrane chromatography at high flow rates
Alternative biological sources for extracellular vesicles production and purification strategies for process scale-up
Full text link: Extracellular vesicles (EVs) are phospholipidic bi-layer enclosed nanoparticles secreted naturally by all cell types. They are attracting increasing attention in the fields of nanomedicine, nutraceutics and cosmetics as biocompatible carriers for drug delivery, with intrinsic properties beneficial to human health. Scientific work now focuses on developing techniques for isolating EVs that can translate into industrial-scale production and meet rigorous clinical requirements. The science of EVs is ongoing, and many pitfalls must be addressed, such as the requirement for standard, reproducible, inexpensive, and Good Manufacturing Practices (GMP) adherent EV processing techniques. Researchers are exploring the use of alternative sources to EVs derived from mammalian cultures, such as plant EVs, as well as the use of bacteria, algae and milk. Regarding the downstream processing of EVs, many alternative techniques to the ultracentrifugation (UC) protocols most commonly used in the laboratory are emerging. In the context of process scale-up, membrane-based processes for isolation and purification of EVs are the most promising, either as stand-alone processes or in combination with chromatographic techniques. This review discusses current trends on EVs source selection and EVs downstream processing techniques, with a focus on plant-derived EVs and membrane-based techniques for EVs enrichment
Uremic toxins removal with mixed matrix membranes adsorbers (MMMAs)
No full textMixed Matrix Membrane Adsorbers (MMMAs) based on Cellulose Acetate (CA) were prepared and tested for the removal of uremic toxins from spent dialysate aqueous streams from hemodialysis treatments. MMMAs were fabricated and modified with a natural zeolite, ZUF, to enhance the affinity towards urea, creatinine and uric acid. Water permeability tests and batch adsorption tests were performed on the prepared MMMAs, obtaining encouraging results. The removal capacity of the pure CA membranes is improved after addition of ZUF by factors as high as 83% for urea and up to 28% for creatinine
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Recovery of lactose from acid whey by nanofiltration: An experimental study
Full text linkThe flowsheet of an overall process to recover valuable products from raw acid whey is proposed. It considers typical pretreatments, an ultrafiltration step to remove proteins, a decalcification step to remove calcium and magnesium by precipitation, and a nanofiltration/diafiltration step for demineralization and deacidification of lactose. The performance of each step is evaluated and the characteristics of the main streams are estimated. The feasibility of lactose recovery after the decalcification step by nanofiltration is demonstrated by using a spiral wound module. Membrane characterization was performed at pH 4 and 50 °C, with an artificial solution containing lactose, lactic acid and sodium chloride, prepared to mimic the clarified supernatant from the decalcification unit. The feasibility of the simultaneous concentration and deacidification of lactose is finally validated by processing a real solution. With the real solution, the maximum removal of lactic acid, close to 87%, is obtained by operating with a nanofiltration (NF) step (at a concentration factor of 3.5) followed by a NF step operated in diafiltration mode (DF) at constant volume (at a dilution factor of 1.8). A lactic acid/lactose ratio of 0.018 g/g is achieved, with an overall lactose purity and yield of 93.6% and 98.2%, respectively, when operating at low pressure values (up to 12-14 bar). A preliminary process simulation is finally performed to identify the premises for process optimization of the NF+DF configuration. The success of the integrated NF+DF process is contingent upon the correct balance between the choice of the membrane and the operating conditions, which ensure lactose rejections exceeding 98.5 % and lactic acid rejections falling below 20-30 %, while maintaining transmembrane fluxes between 8 and 15 dm3/(hm2)
Heat and mass transfer boundary layers in radial creeping flow
No full textHeat and mass transfer in radial flow between two parallel disks are analysed. This kind of problem is sometimes encountered in chemical engineering and we faced this situation in membrane separation processes in which the fluid is fed into the center of the cell and flows towards zones at higher radii. In the examined case heat and/or mass are exchanged across one of the two surfaces which confine the flow region. An analysis of the transport phenomena of such a geometry is performed by resorting to two different mathematical models. As a result the concentration and/or temperature profiles, the transport coefficients and the influence of the relevant dimensionless groups are obtained. The capability of the models to predict the experimental behavior of the vacuum membrane distillation process is demonstrated. © 1994
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