86 research outputs found
Cell-Free Fetal DNA for the Prediction of Pre-Eclampsia at the First and Second Trimesters: A Systematic Review and Meta-Analysis
No full textObjective: A systematic review and pooled analysis was carried out to estimate whether the increase in the quantity of cell-free fetal DNA (cffDNA) before the onset of pre-eclampsia (PE) can predict the disease using real-time polymerase chain reaction (PCR). Method: A comprehensive literature search of the PubMed, Scopus, and Web of Knowledge databases was conducted to identify relevant studies that included evaluated cffDNA levels in pregnant women before the clinical onset of PE. A simulation model was generated to calculate the detection rate (DR) of cffDNA for PE, and a random variable was generated using the same number of cases and same statistical measurements of central tendency and dispersion as those reported in the papers considered for the analysis. Simulation of the receiver operating characteristic (ROC) curves was also carried out. Results: Four studies (82 cases and 1315 controls) evaluated cffDNA in early-onset PE, with DRs of 18 and 68.8% at 11â13 and 17â28 weeks, respectively, at a false positive rate of 10%. Nine studies (including two considered for early-onset PE) encompassing 376 cases and 1270 controls were available for the evaluation of âany PEâ. At 11â14 weeks no significant DR was found, while at 15â28 weeks the DR was 37%. Conclusion: CffDNA quantification is a marker for predicting the development of both early-onset PE and âany PEâ; however, it can probably only be used from the beginning of the second trimester, otherwise its predictive value is burdened with a DR that is too low or not significant. Due to the heterogeneity and difficulty in interpreting the published data, no conclusion regarding the statistical and clinical relevance, especially for screening âany PEâ, can be made at present
A First-Trimester Biomarker Panel for Predicting the Development of Gestational Diabetes
No full textObjective: Serum markers measured early in pregnancy have been associated with the later diagnosis of gestational diabetes mellitus (GDM). This study aims to explore the performance of a panel of first-trimester biochemical markers for the prediction of GDM. Methods: A case-control study was performed that included 12 women who developed GDM and 60 controls matched for maternal and gestational age at blood collection. Levels of pregnancy-associated plasma protein A (PAPP-A), soluble endoglin, pregnancy protein 13, and adiponectin (Adipo) were measured on residual sera used in first-trimester screening for Down syndrome. Data were analyzed by nonparametric methods. A receiver operating characteristic curve was used to calculate the detection rate (DR) obtained with a panel of significant predictors for GDM. Results: Multiples of the median values for Adipo and PAPP-A were significantly reduced in GDM cases versus matched controls. Combination of Adipo and PAPP-A yielded a DR of 63.6% at a false-positive rate of 10%. Addition of body mass index (BMI) to this panel increased DR to 72.7%. Conclusion: This study suggests that first-trimester screening with Adipo, PAPP-A, and BMI may effectively identify women at high risk for the development of GDM
Elevated maternal placental protein 13 serum levels at term of pregnancy in postpartum major hemorrhage (>1000Â mLs). A prospective cohort study
No full textProblem: To compare placental protein 13 (PP13) levels in the serum of women with primary postpartum hemorrhage (PPH) with a control population. Methods: A prospective cohort study was conducted between May 2014 and May 2016 and included 435 pregnant women at term (38 weeks gestation) without any known risk factor and with normal labor. Multiples of median (MoM) were used to evaluate differences of the PP13 values between cases and controls. PP13 concentrations were adjusted for maternal and neonatal weight. Multivariable analysis was used to detect independent contribution of predictors of PPH. Results: Fifteen had a major PPH >1000 mLs and represented the cases of the study. They were matched with 399 controls. Twenty-one patients who had a minor PPH (500-1000 mLs) were excluded. The mean observed rank in the PPH group was higher than that of controls (28.5 vs 13.5, P-value=.01). PP13 MoM values adjusted for maternal weight were higher than expected being 1.44±0.45 in PPH cases and 1.00±0.59 in controls (P-value.008). This difference was still significant even after adjustment for neonatal weight that represented a confounding variable. Conclusion: Higher PP13 levels are independently associated with major PPH >1000 mLs
Fetal cerebellar damage in fetuses with severe anemia undergoing intrauterine transfusions
No full textObjective: To evaluate radiologic findings and outcomes of cerebellar injuries in fetuses with severe anemia due to RhD alloimmunization undergoing intrauterine transfusions.Methods: Imaging of multiplanar neurosonography and magnetic resonance imaging (MRI) were reviewed. Pregnancy outcomes were recorded.Results: Cerebellar injuries were identified after the first intravascular transfusion in four fetuses. Two of these cases were previously reported. The median hemoglobin concentration was 2.1 g/dL. Prenatal neurosonography identified an echogenic collection involving the cerebellum suggestive for hemorrhage in three cases. A progressive hypoplasia of a hemisphere was demonstrated at follow-up examination in one of these cases. Hypoplasia of a cerebellar hemisphere was seen in the fourth fetus. Ultrasound diagnosis was confirmed by prenatal MRI in two cases. In the third case, the postnatal MRI showed as additional finding vermian involvement. One pregnancy was terminated and autopsy confirmed the presence of infratentorial hemorrhage. The remaining infants were delivered alive. At time of writing, a truncal ataxia was diagnosed in the child with vermian hypoplasia, while the other children have met all age-appropriate milestones.Conclusions: A severe anemia seems to put the fetus at risk of cerebellar damage, despite successful intravascular transfusion
Les Enfants de l’ombre: Dalila Kerchouche. Leila: Avoir dix-ans dans un camp de harkis
No full textDans son roman, Leila : Avoir 17 ans dans un camp de harkis, Dalila Kerchouche retrace le parcours de ceux dont la jeunesse fut passée/gâchée dans les camps de la relégation. À travers le regard blessé d’une adolescente de 17 ans, on découvre ce que l’histoire officielle a voulu couvrir du manteau de l’oubli : l’arrivée précipitée des harkis et leurs familles en France, leur dur quotidien dans les camps en marge de la communauté nationale, leur dépouillement, les humiliations, les souffrances, les folies et une gestion étatique aussi choquante qu’incohérente. Le présent article examine la portée individuelle et collective de cette œuvre née de l’hantologie, d’un passé toujours revenant, toujours fragmenté, et dont elle tente d’appréhender les apories. In her 2006 novel, Leila: Avoir 17 ans dans un camp de harkis, Dalila Kerchouche traces the tragic history of those who spent their youth confined in camps. Through the bewildered and wounded gaze of a 17 year-old young harki daughter, we are gradually introduced to life behind closed gates and barbed wires. The author unveils the dramatic events that official history has shrouded in silence and forgetfulness: the chaotic arrival of the harkis and their families in France, the daily hardships they endured in the camps, their life at the margins of the national community, their deprivations, humiliations, sufferings, and the French State’s incomprehensible management of this situation. The present article examines the personal and political meaning of this text which is haunted by the past, an unfinished past, always present and fragmented
Finance and Credit Market
No full textIn this chapter, the author (Dalila Nicet-Chenaf) draws from the literature a set of variables describing financial systems, their different forms and type of institutional governance. The analysis then proceeds by contrasting the various types of financial sector governance in terms of their degree of financial depth and their particular banking and market-finance mix, four financial models are identified. The intermediated (repressed) model is typical of many developing and emerging economies. It is characterized by limited financial depth, high state banking sector regulation levels, financial repression and low levels of investor and creditor protection. Some emerging economies exhibit embryonic models marked by intermediate degrees of financial depth and a significant bias towards banking finance. The mature model has high depth and relatively even proportions of banking and market finance
A Harki History Lesson: Dalila Kerchouche’s Filiation Narrative Mon père, ce harki
No full textThis article reads Dalila Kerchouche’s Mon père, ce harki (My Father, this Harki) as a postcolonial filiation narrative, which blends memoir and biography, the personal and collective, the past and present. Lack of knowledge and a desire to see for herself the camps her parents and older siblings experienced prompts Kerchouche to adopt an investigative posture characterized by in situ exploration in conjunction with interviews and the consultation of archives. This allows the author to achieve a polyphonic account of the past. At the same time, her family serves as the prism through which she confronts the stigma attached to Harkis (Algerian soldiers hired by the French Army) and examines their unjust treatment in France
Model-Driven Software Evolution: A Research Agenda
No full textSoftware systems need to evolve, and systems built using model-driven approaches are no exception. What complicates model-driven engineering is that it requires multiple dimensions of evolution. In regular evolution, the modeling language is used to make the changes. In meta-model evolution, changes are required to the modeling notation. In platform evolution, the code generators and application framework change to reflect new requirements on the target platform. Finally, in abstraction evolution, new modeling languages are added to the set of (modeling) languages to reflect increased understanding of a technical or business domain. While MDE has been optimized for regular evolution, presently little or no support exists for metamodel, platform and abstraction evolution. In this paper, we analyze the problems raised by the evolution of model-based software systems and identify challenges to be addressed by research in this area. To be presented at the CSMR 2007 Workshop on Model-Driven Software Evolution (MoDSE), Amsterdam, 20 March 2007.Software TechnologyElectrical Engineering, Mathematics and Computer Scienc
Three acts: Cabinets of Curiosities, Curatorship and Museums
No full textDissertação de Mestrado em Estudos Curatoriais apresentada ao Colégio das ArtesNesta dissertação abordam-se considerações históricas e críticas sobre os temas “Gabinete de Curiosidades, Curadoria e Museus”, tanto setorialmente, como nas suas múltiplas relações. São tidos em conta contributos teóricos relevantes de diversos autores, tais como: Collen J. Sheehy, Dalila Rodrigues, Gilmar de Carvalho, Jacques Le Goff, Sharon Macdonald, Stephanie Jane Bowry, Delfim Sardo, Nuno Grande, Rosalind Krauss, Roland Barthes, Beatrice von Bismark, Jens Hoffmann, Alan Roth e Sevova, Felix Vogel e Patrick Mauriés. No primeiro capítulo, apresenta-se uma contextualização do tema “gabinetes de curiosidades”. Tendo como base a ideia essencial de que são suportes e dispositivos utilizados pelo homem como depositários de objetos para comemorar a memória, a pesquisa destaca algumas contribuições, designadamente de Quicchenberg, para o estudo da genealogia dos gabinetes de curiosidades. Ainda neste capítulo, selecionam-se e analisam-se contributos dos seguintes artistas: Arthur Bispo do Rosário; a dupla Robert Williams e Mark Dion e, por último, Marcel Duchamp. O ato de selecionar, considerado no primeiro capítulo, promoveu a possibilidade de abordar, no capítulo seguinte, a prática curatorial e, sobretudo, a ideia do curador como autor, ou ainda do artista como curador. Buscou-se uma análise crítica da atividade da curadoria, colocando em perspectiva os fabricantes de exposições, a ideia de liberdade curatorial e a efemeridade das exposições. O tema “gabinetes de curiosidades” impulsionou a elaboração do terceiro capítulo, que é dedicado a museus, coleções, dispositivos de exibição, preservação, conservação e mediação na atualidade. Seguidamente, propõe-se um olhar ao museu como espaço metafórico. No final deste capítulo, apresenta-se um estudo de caso de práticas contemporâneas de dois museus em Portugal, nomeadamente, do Atelier Museu Júlio Pomar e do Museu Serralves. A relação entre homens e objetos é abordada no quarto capítulo. Buscou-se, através de apontamentos de diversos autores, refletir sobre o valor atribuído aos artefatos, sobre o poder evocativo dos objetos, assim como sobre os objetos enquanto “bens culturais” e o processo da sua patrimonialização. No quinto capítulo estabelecem-se relações possíveis entre as salas dos milagres, os gabinetes de curiosidades e analisam-se duas obras do artista francês Arman. Neste capítulo, apresenta-se, ainda, o trabalho prático que se desenvolveu paralelemente à pesquisa e à redação da presente dissertação.In this dissertation, historical and critical considerations about the themes "Cabinet of Curiosities, Curatorship and Museums" are discussed, both in the sector and in their multiple relations. Relevant theoretical contributions of several authors are taken into account, such as: Collen J. Sheehy, Dalila Rodrigues, Gilmar de Carvalho, Jacques Le Goff, Sharon Macdonald, Stephanie Jane Bowry, Delfim Sardo, Nuno Grande, Rosalind Krauss, Roland Barthes, Beatrice von Bismark, Jens Hoffmann, Alan Roth and Sevova, Felix Vogel and Patrick Mauriés.In the first chapter, a contextualization of the theme "cabinets of curiosities" is presented. Based on the essential idea that they are supports and devices used by man as depository of objects to celebrate memory, the research highlights some contributions, namely Quicchenberg, for the study of the genealogy of the curiosities cabinets. Also in this chapter, the following artists are selected and analyzed: Arthur Bispo do Rosário; the duo Robert Williams and Mark Dion and, finally, Marcel Duchamp. The act of selecting, considered in the first chapter, promoted the possibility of approaching, in the next chapter, curatorial practice and, above all, the idea of the curator as author, or even of the artist as curator. A critical analysis of the activity of the curators was sought, placing in perspective the exhibition manufacturers, the idea of curatorial freedom and the ephemerality of the exhibitions. The theme "cabinets of curiosities" has led to the elaboration of the third chapter, which is dedicated to museums, collections, exhibition devices, preservation, conservation and mediation today. Next, we propose a look at the museum as a metaphorical space. At the end of this chapter, a case study of contemporary practices of two museums in Portugal is presented, namely the Atelier Museu Júlio Pomar and the Serralves Museum. The relationship between men and objects is addressed in the fourth chapter. It was sought, through notes of various authors, to reflect on the value attributed to artifacts, on the evocative power of objects, as well as on objects as "cultural heritage" and the process of their patrimonialization. In the fifth chapter, possible relations between the miracle halls, the curiosities cabinets are established, and two works by the French artist Arman are analyzed. In this chapter, we also present the practical work developed in parallel to the research and writing of this dissertation
Théatre complet /
No full textAuthor at head of title.I. Un bourgeois de Rome. Le pour et le contre. La crise péril en la demeure. Le village. La Fée le roman d'un jeune homme pauvre -- II. Le cheveu blanc. La tentation. ReÌdemption. Montjoye -- III. Le belle au bois dormant. Le cas de conscience. Julie. Dalila. L'acrobate -- IV. Le sphinx. Un roman parisien. La partie de dames. Chamillac -- V. Echec et mat. Palma ou la nuit du vendredi saint. La vieillesse de Richelieu. York.Mode of access: Internet
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