1,721,018 research outputs found
Effect of JAK2v617F mutation in polycythemia vera on clinical course and disease outcomes
No full textTıp Fakültesi, İç Hastalıkları Ana Bilim DalıGiriş: Polisitemia Vera (PV) klonal hematopoezin örneklerinden biri olan miyeloproliferatif hastalıklardan biridir. Klonal çoğalma başta eritroid seri olmak üzere granülositik ve trombositik serideki her üç hücrenin anormal çoğalmasıyla karakterize bir durumdur. Gereç ve Yöntem: İnönü Üniversitesi Tıp Fakültesi Hastanesi İç Hastalıkları Hematoloji kliniğinde 01.01.2009-01.012024 yılları arasında takip edilen 99 PV tanılı hasta çalışmaya dahil edildi. Çalışmada hastaların adı, soyadı, protokol numarası, yaş, cinsiyet, tanı anındaki risk skorlaması, tanı anında başlanan tedavi ve takiplerinde uygulanan en son tedavi, tanıdaki laboratuvar (hemoglobin, hematokrit, lökosit ve trombosit) değerleri, kan biyokimyası, serum EPO, LDH, abdomenin radyolojik görüntülemesi, kemik iliği aspirasyon ve biyopsi verileri, JAK 2 gen mutasyonu sonuçları ve görülen komplikasyonları (tanı anındaki ve takipteki arterial ve venöz tromboz durumu) içeren bilgiler retrospektif olarak incelendi ve kaydedildi. Bulgular: JAK2 sınıflamasına göre tanı sırası dalak boyutu dağılımı açısından istatistiksel olarak anlamlı bir farklılık tespit edilmiştir. WBC değerleri bakımından JAK2V617F Allel yük sınıflaması ikili karşılaştırmalarda Pozitif %12.5-31 — Pozitif %78-100, arasında istatistiksel olarak anlamlı bir fark tespit edilmiştir. JAK2 sınıflamasına göre bireylerin HGB, HCT, PLT, LDH değerleri arasında istatistiksel olarak anlamlı bir farklılık saptanmamıştır Sonuçlar: Sonuç olarak JAK2v617F mutasyonu PV hastalığının ayrılmaz bir parçasıdır. Bizde çalışmamızda bu mutasyonun allel yük ve hastalığın diğer parametreleri arasındaki ilişkiyi açıklamaya ve hastalığın tedavisine etkisine araştırmayı amaçladık. Çalışmamızda splenomegalı ve WBC değerleri bakımından anlamlı bir ilişki bulunmuşken diğer parametreler ile arasında anlamlı bir ilişki bulunmamıştır. JAK2v617F alel yükünün uzun vadeli izlenmesinin klinik değeri üzerine yapılacak daha fazla araştırma, prognoz çıkarımı yapma, izleme stratejilerine rehberlik etme ve tedavi planlarını tasarlama açısından değerli olabilir. Anahtar Kelimeler: Polisitemia Vera, JAK2v617F mutasyonu, Splenomegali, Miyeloproliferatif NeoplazmIntroduction: Polycythemia Vera (PV) is one of the myeloproliferative diseases that are examples of clonal hematopoiesis. Clonal proliferation is a condition characterized by abnormal proliferation of all three cells in the granulocytic and thrombocytic series, especially the erythroid series. Material and Methods: 99 patients diagnosed with PV who were followed up at İnönü University Faculty of Medicine Hospital Internal Medicine Hematology Clinic between 01.01.2009 and 01.012024 were included in the study. In the study, the patients' name, surname, protocol number, age, gender, risk scoring at the time of diagnosis, treatment started at the time of diagnosis and the last treatment applied during follow-up, laboratory (hemoglobin, hematocrit, leukocyte and platelet) values at diagnosis, blood biochemistry, serum EPO, LDH, Information including radiological imaging of the abdomen, bone marrow aspiration and biopsy data, JAK 2 gene mutation results and complications (arterial and venous thrombosis status at diagnosis and during follow-up) were retrospectively examined and recorded. Results: A statistically significant difference was detected in spleen size distribution at diagnosis according to JAK2v617F Allele load classification. In terms of WBC values, a statistically significant difference was detected between Positive 12.5-31% - Positive 78-100% in pairwise comparisons of JAK2v617F Allele load classification. According to the JAK2 classification, no statistically significant difference was found between the HGB, HCT, PLT, LDH values of individuals. Conclusion: In conclusion, JAK2v617F mutation is an integral part of PV disease. In our study, we aimed to explain the relationship between the allele load of this mutation and other parameters of the disease and to investigate its effect on the treatment of the disease. While a significant relationship was found in terms of splenomegaly and WBC values in our study, no significant relationship was found with other parameters. Further research on the clinical value of long-term monitoring of JAK2V617F allele burden may be valuable for inferring prognosis, guiding monitoring strategies, and designing treatment plans. Keywords: Polycythemia Vera, JAK2v617F mutation, Splenomegaly, Myeloproliferative Neoplas
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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