1,721,265 research outputs found
Cardiovascular adverse reactions after the administration of recombinant human erythropoietin: light and shade.
No full textState of art on the role of ischemic time in ST-segment elevation myocardial infarction treated with PTCA
No full textCollaborative care for depression in European countries: A systematic review and meta-analysis
No full textOBJECTIVES: This is a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the effectiveness of collaborative care compared to Primary Care Physician's (PCP's) usual care in the treatment of depression, focusing on European countries.
METHODS: A systematic review of English and non-English articles, from inception to March 2014, was performed using database PubMed, British Nursing Index and Archive, Ovid Medline (R), PsychINFO, Books@Ovid, PsycARTICLES Full Text, EMBASE Classic+Embase, DARE (Database of Abstract of Reviews of Effectiveness) and the Cochrane Library electronic database. Search term included depression, collaborative care, physician family and allied health professional. RCTs comparing collaborative care to usual care for depression in primary care were included. Titles and abstracts were independently examined by two reviewers, who extracted from the included trials information on participants' characteristics, type of intervention, features of collaborative care and type of outcome measure.
RESULTS: The 17 papers included, regarding 15 RCTs, involved 3240 participants. Primary analyses showed that collaborative care models were associated with greater improvement in depression outcomes in the short term, within 3 months (standardized mean difference (SMD) -0.19, 95% CI=-0.33; -0.05; p=0.006), medium term, between 4 and 11 months (SMD -0.24, 95% CI=-0.39; -0.09; p=0.001) and medium-long term, from 12 months and over (SMD -0.21, 95% CI=-0.37; -0.04; p=0.01), compared to usual care.
CONCLUSIONS: The present review, specifically focusing on European countries, shows that collaborative care is more effective than treatment as usual in improving depression outcomes
La scoperta del "continente inesplorato" dei disturbi mentali nella medicina generale ed i suoi effetti sullo stile di lavoro degli psichiatri nella comunità. Introduzione
No full textDisability associated with depressive symptoms in elderly primary care attenders
No full textLate-life depression is common, disabling and frequently comorbid with physical illness. This study examines a sample of 453 primary care attenders aged 65 years or over. In the screning phase the general health questionnaire-12 (GHQ-12) and the brief disability questionnaire (BDQ) were administered, and the primary care physicians (PCPs) rated the severity of physical illness and recorded the frequency of consultations. PCPs assessed GHQ high scores using the WHO ICD-10 checklist for depression to diagnose ICD-10 defined major episode of depression and subsyndromal depression (SSD), according to Olfson criteria. Mean BDQ score was 5.5 (± 4.9) in non-depressed subjects, 8.8 (± 5.9) in attenders with SSD, and 12.7 (± 5.9) in depressed attenders, with significant differences in each pairwise comparison. Both physical illness and depression independently result in an increased disability and PCP consultation, and when the two conditions are present, they have additive effect. Significant functional impairment is present not only in patients with full-fledged depression, but also in those with just symptoms of depression. Depression and physical illness can negatively ampact each other, resulting in persistent disability and poor prognosis
Atypical neuroleptic malignant syndrome associated with clozapine treatment
No full textClozapine is an atypical neuroleptic drug that was initially thought not to cause neuroleptic malignant syndrome (NMS). The authors report a case of NMS associated with clozapine use, developed in a patient without previous history of NMS. Considering that 13 such cases (including ours) have been reported so far, NMS should be considered in the differential diagnosis of a febrile patient treated with clozapin
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
La Schizofrenia
No full textNel capitolo si delineano le principali nozioni su epidemiologia, clinica e terapia della Schizofrenia
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