88,412 research outputs found
De novo mammalian prion synthesis
No full textPrions are responsible for a heterogeneous group of fatal neurodegenerative diseases. They can be sporadic, genetic, or infectious disorders involving post-translational modifications of the cellular prion protein (PrP(C)). Prions (PrP(Sc)) are characterized by their infectious property and intrinsic ability to convert the physiological PrP(C) into the pathological form, acting as a template. The "protein-only" hypothesis, postulated by Stanley B. Prusiner, implies the possibility to generate de novo prions in vivo and in vitro. Here we describe major milestones towards proving this hypothesis, taking into account physiological environment/s, biochemical properties and interactors of the PrP(C)
Il sistema culturale: offerta, consumo, politiche
No full textThis paper is organized in two parts: the first represents a synthetic mapping of the current cultural
offer within Provincia di Trento. existing institution operating in the cultural field have therefore been
tracked, and sorted out depending from their field of activity (museums, ecomuseums, natural parks,
other organizations). Relations among organizations and institutions involved have been tracked as
well. Monographic XX in attachment for each institution involved complete the paper. The second part
analyses local cultural policies, starting from an historical overview, and going then in depth with the
specific issue of cultural policies arisen in this context
Screening for diabetic retinopathy: 1 and 3 nonmydriatic 45-degree digital fundus photographs vs 7 standard early treatment diabetic retinopathy study fields.
No full textAm J Ophthalmol. 2009 Jul;148(1):111-8. Epub 2009 May 5.
Screening for diabetic retinopathy: 1 and 3 nonmydriatic 45-degree digital fundus photographs vs 7 standard early treatment diabetic retinopathy study fields.
Vujosevic S, Benetti E, Massignan F, Pilotto E, Varano M, Cavarzeran F, Avogaro A, Midena E.
Source
Fondazione G.B. Bietti per l'Oftalmologia, IRCCS (Istituto di Ricovero e Cura a Carattere Scientificio), Roma, Italy.
Abstract
PURPOSE:
To evaluate if simple- or multiple-field digital color nonmydriatic (NM) retinal images can replace 7 standard stereoscopic fundus photographs in the screening of diabetic retinopathy (DR).
DESIGN:
Prospective, masked, comparative case series.
METHODS:
One hundred and eight eyes of 55 diabetics were studied to determine single lesions and to grade clinical levels of DR and diabetic macular edema (DME) using both 1 and 3 NM digital color retinal images compared with the Early Treatment Diabetic Retinopathy Study (ETDRS) 7 standard 35-mm stereoscopic color fundus photographs (7F-ETDRS). All eyes underwent NM 45-degree field images of 1 central field (1F-NM), NM 45-degree field images of 3 fields (3F-NM), and, after pupil dilatation, 30-degree 7F-ETDRS photography. Images were analyzed by 2 independent, masked retinal specialists (S.V. and E.B.), lesion-by-lesion according to the ETDRS protocol and for clinical severity level of DR and DME according to the international classification of DR.
RESULTS:
Using 7F-ETDRS as the gold standard, agreement was substantial for grading clinical levels of DR and DME (kappa = 0.69 and kappa = 0.75) vs 3F-NM; moderate for DR level (kappa = 0.56) and substantial for DME (kappa = 0.66) vs 1F-NM; almost perfect for detecting presence or absence of DR (kappa = 0.88) vs both 1F-NM and 3F-NM; and almost perfect for presence or absence of DME (kappa = 0.97) vs 3F-NM and substantial (kappa = 0.75) vs 1F-NM. Sensitivity and specificity for detecting referable levels of DR were 82% and 92%, respectively, for 3F-NM and 71% and 96%, respectively, for 1F-NM.
CONCLUSIONS:
Three color 45-degree NM fundus fields may be an effective tool in a screening setting to determine critical levels of DR and DME for prompt specialist referral. One central 45-degree image is sufficient to determine absence or presence of DR and DME, but not for grading it
Sistemi decorativi della pittura antica: funzione e contesto, Atti del II Colloquio AIRPA (Pisa 14-15 giu. 2018),
No full textAtti del II Colloquio AIRPA (=Associazione Italiana Ricerche Pittura Murale Antica), Pisa 14-15 giugno 201
Hydraena bahiana sp. n., a new minute moss beetle (Coleoptera, Hydraenidae) from highlands of Northeast Brazil
No full textBenetti, Cesar J., Valladares, Luis F., Delgado, Juan A., Hamada, Neusa (2022): Hydraena bahiana sp. n., a new minute moss beetle (Coleoptera, Hydraenidae) from highlands of Northeast Brazil. Zootaxa 5128 (4): 538-546, DOI: https://doi.org/10.11646/zootaxa.5128.4.
Gyretes brunnescens Ochs 1953
No full textGyretes brunnescens Ochs, 1953 Gyretes brunnescens Ochs, 1953 a: 148 (orig. descr.); 1957: 213 (record); 1960 a: 185, f. 6 (descr., illustr.); 1960 b: 312 (record); 1963 c 466 (record); 1965 a: 307, 310 (descr.); 1966: 449, 461 (descr.); 1969: 383 (ethology, ecology); Benetti et al. 2003 b: 38, 42 (record, distr.); Benetti & Garrido 2004: 160 (record, distr.); Benetti & Régil 2004: 6 (ecology) DISTRIBUTION: Argentina, Brazil (PR, RS, SC), Paraguay, Uruguay.Published as part of Colpani, Daniara, Benetti, Cesar João & Hamada, Neusa, 2014, A Checklist of the Gyrinidae (Coleoptera: Adephaga) of Brazil, pp. 185-213 in Zootaxa 3889 (2) on page 192, DOI: 10.11646/zootaxa.3889.2.2, http://zenodo.org/record/23012
Updating constraints on f(T) teleparallel cosmology and the consistency with Big Bang Nucleosynthesis
No full textWe focus on viable f(T) teleparallel cosmological models, namely power law, exponential, and square-root exponential, carrying out a detailed study of their evolution at all scales. Indeed, these models were extensively analysed in the light of late time measurements, while it is possible to find only upper limits looking at the very early time behaviour, i.e. satisfying the big bang nucleosynthesis (BBN) data on primordial abundance of He-4. Starting from these indications, we perform our analysis considering both background and linear perturbations evolution and constrain, beyond the standard six cosmological parameters, the free parameters of f(T) models in both cases whether the BBN consistency relation is considered or not. We use a combination of Cosmic Microwave Background, Baryon Acoustic Oscillation, Supernovae Ia and galaxy clustering measurements, and find that very narrow constraints on the free parameters of specific f(T) cosmology can be obtained, beyond any previous precision. While no degeneration is found between the helium fraction, Y-P, and the free parameter of f(T), we note that these models constrain the current Hubble parameter, H-0, higher extent than the standard model one, fully compatible with the Riess et al. measurement in the case of power-law f(T) model. Moreover, the free parameters are constrained at non-zero values in more than 3-sigma, showing a preference of the observations for extended gravity models
Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits
No full textNeurodegenerative diseases are incurable debilitating disorders of the nervous system that affect approximately 30 million people worldwide. Despite profuse efforts attempting to define the molecular mechanisms underlying neurodegeneration, many aspects of these pathologies remain elusive. The novelty of their mechanisms represents a challenge to biology, to their related biomarkers identification and drug discovery. Because of their multifactorial aspects and complexity, gene expression analysis plat- forms have been extensively used to investigate altered pathways during degeneration and to identify potential biomarkers and drug targets
Gyretes levis subsp. australis Ochs 1960
No full textGyretes levis australis Ochs, 1960 Gyretes levis australis Ochs, 1960 b: 311, f. 3 (orig. descr., illustr.); Benetti et al. 2003 b: 38, 42 (record, distr.); Benetti & Régil 2004: 6 (ecology) Gyretes laevis australis Ochs: Marinoni et al. 1992: 121 (type list, misspelling) DISTRIBUTION: Brazil (RS).Published as part of Colpani, Daniara, Benetti, Cesar João & Hamada, Neusa, 2014, A Checklist of the Gyrinidae (Coleoptera: Adephaga) of Brazil, pp. 185-213 in Zootaxa 3889 (2) on page 199, DOI: 10.11646/zootaxa.3889.2.2, http://zenodo.org/record/23012
Gyretes tarsalis subsp. chapadensis Ochs 1960
No full textGyretes tarsalis chapadensis Ochs, 1960 Gyretes tarsalis chapadensis Ochs, 1960 b: 310, f. 1, 2 (orig. descr., illustr.); 1963 c: 468 (record); Marinoni et al. 1992: 122 (type list); Benetti & Régil 2004: 6 (ecology); Benetti et al. 2003 b: 39, 42 (record, distr.) DISTRIBUTION: Brazil (RS).Published as part of Colpani, Daniara, Benetti, Cesar João & Hamada, Neusa, 2014, A Checklist of the Gyrinidae (Coleoptera: Adephaga) of Brazil, pp. 185-213 in Zootaxa 3889 (2) on page 207, DOI: 10.11646/zootaxa.3889.2.2, http://zenodo.org/record/23012
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