1,720,980 research outputs found
Cerebral choline acetyltransferase and acetylcholinesterase activities in a Sanfilippo syndrome, in a myoclonic epilepsy and in various zones of the human newborn brain
No full textAcetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities were measured in the brain of two cases: a Sanfilippo syndrome and a myoclonic epilepsy. Both AChE and ChAT activities were decreased in the Sanfilippo mucopolysaccharidosis, while only ChAT was decreased in the myoclonic epilepsy. These findings can be related to the epileptic phenomena and/or to the degenerative processes which take place in the cerebral cholinergic pathways, due to the dismetabolic diseases. ChAT and AChE activities were also analyzed in different brain regions of an 8 day old newborn infant. The highest activity was not found in the basal nuclei, but in the cerebellum which is known, in the adult, to contain very little AChE and ChAT activities
Immunohistochemical evidence for enhanced Epidermal Growth Factor Receptor expression in human thymomas
No full textIL-6, monocyte infiltration and parenchymal cells
No full textThe January issue of Trends in Immunology contained an
interesting article by Kaplanski et al., in which the authors
observed that interleukin-6 (IL-6) acts as a switch,
regulating the transition from neutrophil to monocyte
involvement during the inflammatory response [1]. In this
model, activated polymorphonuclear (PMN) cells release
soluble interleukin-6 receptor a (sIL-6Ra), which, upon
binding of locally produced IL-6, combines with glycoprotein
130 (gp130) on endothelial cells, enabling them to
switch from IL-8 (neutrophil-recruiting) to monocyte
chemotactic protein-1 (monocyte-recruiting) secretio
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Analysis od IL-6 secretion by human thymic epithelial cells in culture from patients with myasthenia gravis: preliminary results
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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