1,721,318 research outputs found
Relation between chronic gastritis, Helicobacter pylori and HLA: role of DQA1 and DQB1 molecular alleles
No full textNo abstract available
Feline immunodeficiency virus infection
No full textPathophysiology Feline immunodeficiency virus (FIV) infection leads to a progressive immunologic dysregulation due to a constant loss of lymphocytes (particularly CD4+ T lymphocytes), changes in cytokine patterns, and an increase of circulating immunoglobulin G (IgG). The progressive immunopathology predisposes to severe secondary diseases such as opportunistic infections, neoplasia, neurologic disease, and wasting syndrome.
Clinical Signs The initial acute phase of infection is characterized by nonspecific clinical signs such as anorexia, depression, fever and generalized lymphadenomegaly that may go unnoticed, evolving in a clinically latent stage. In the terminal phase of infection, infected cats may develop clinical signs related to secondary diseases, including opportunistic infections, myelosuppression, neurologic dysfunction, and neoplasia.
Diagnosis Clinical suspicion is based on the association of known risk factors (sex, age and lifestyle) with clinical signs and biochemical abnormalities. A complete blood cell count may reveal mild neutropenia in the initial acute phase and pancytopenia (lymphopenia, anemia and neutropenia) in the terminal phase of infection. Hypergammaglobulinemia is normally reported.
Other hematological and biochemical abnormalities may be due to secondary diseases. The detection of FIV-specific antibodies in blood confirms the diagnosis of infection.
Therapy Proper management of infected cats is essential to reduce secondary infections and avoid viral transmission. If secondary diseases are diagnosed, appropriate treatment is recommended. Antivirals and immunomodulators can be considered for FIV-infected cats. Zidovudine (5-10 mg/kg PO q12h) can be effective in the treatment of FIV-associated stomatitis or neurological disorders. Human interferon-alpha (IFN-α) administered at high (104-106 U/kg SC q24h) or low (1-50 U/kg PO q24h) doses and feline interferon-omega (IFN-ω) administered subcutaneously (106 IU/kg q24h on 5 consecutive days) or orally (105 IU/cat q24h on 90 consecutive days) can be employed.
Prognosis In most cases, FIV-infected cats live many years with a high quality of life and die at an old age from causes secondary to FIV infection
Role of HLA-DR and HLA-DQ antigens in the pathogenesis of chronic superficial gastritis and in the H. pylori infection.
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Helicobacter pylori and human leucocyte antigens. Role of DR and DQ antigens in bacterial infection and the pathogenesis of chronic superficial gastritis.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
'Literary Dublin' e 'Disgelo ipertestuale': due viaggi virtuali tra letteratura e contemporaneità
No full textIl contributo presenta due progetti ipertestuali quali esempi possibili di educazione letteraria integrata realizzabile attraverso la tecnologia ipertestuale
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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