1,720,956 research outputs found
The involvement of micro-RNAs in cardiovascular pathologies
Full text linkUniversitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroduction. Micro-RNAs are short molecules of ribonucleic acid with significant regulatory functions in controlling gene expression within eukaryotic cells. These small molecules play a crucial role in post-transcriptional regulation, influencing various cellular processes. Currently, circulating miRNAs are recognized as potential diagnostic biomarkers and emerging therapeutic targets for cardiovascular diseases. Their stability in body fluids and differential expression patterns in various cardiac conditions make them promising candidates for further research and clinical applications in the field of cardiology. Aim of study. Understanding the involvement of miRNAs in cardiovascular disease development is crucial for enhancing diagnostic precision, predicting disease progression, and pinpointing effective therapeutic targets. This exploration aims to refine diagnosis, prognosis, and therapeutic strategies in the managing cardiovascular conditions. Methods and materials. A comprehensive literature review has been performed, covering the past decade and incorporating information from 30 sources. These sources encompassed materials from the Scientific Medical Library of "Nicolae Testemitanu" State University of Medicine and Pharmacy. Additionally, electronic libraries, including PubMed, Elsevier, Cambridge Journals Online, Hinari, Medline and MedScape have been utilized to gather relevant data. Results. Several studies have underscored the pivotal role of micro-RNAs in both diagnosing and treating cardiovascular diseases. Notably, elevated levels of miRNA-636, miRNA-380, and miRNA-17 have been observed in the plasma of individuals experiencing acute myocardial infarction (AMI). Additionally, miRNA-126, miRNA-37, and miR-221 show increased levels in heart failure patients. Furthermore, the prognostic efficacy of miRNA-182 surpasses that of natriuretic peptide and high-sensitivity C-reactive protein in heart failure (HF). Other studies have shown that MiR-499 had a more precise and significantly higher predictive value than the most reliable biomarkers for AMI: c troponin I (cTnI) and creatinkinase MB (CK-MB). In mouse models, intramyocardial injection of vesicles containing miRNA-99 has demonstrated a preventive effect on hypoxia-induced apoptosis and promoted autophagy. This intervention has resulted in improved left ventricular function and increased survival during four weeks after AMI. Conclusion. Presently, miRNAs have the potential to be employed for diagnostic and therapeutic purposes in various cardiovascular diseases. They exert their influence on specific cellular pathways or processes through structures like liposomes, vesicles, or viral vectors designed for intracellular miRNA delivery. functions in controlling gene expression within eukaryotic ce lls. These small molecules play a crucial role in post-transcriptional regulation, influencing various cellular processes. Currently, circulating miRNAs are recognized as potential diagnostic bio markers and emerging therapeutic targets for cardiovascular diseases. Their stability in body fluids and differential expression patterns in various cardiac conditions make them promisi ng candidates for further research and clinical applications in the field of cardiology. Aim of study. Understanding the involvement of miRNAs in cardiovascular d isease development is crucial for enhancing diagnostic precision, predictin g disease progression, and pinpointing effective therapeutic targets. This exploration aims to r efine diagnosis, prognosis, and therapeutic strategies in the managing cardiovascular conditions. Methods and materials. A comprehensive literature review has been performed, cov ering the past decade and incorporating information from 30 sources. These sources encompassed materials from the Scientific Medical Library of "Nicolae Testemitanu" State University of Medicine and Pharmacy. Additionally, electronic libraries, including Pub Med, Elsevier, Cambridge Journals Online, Hinari, Medline and MedScape have been utilized to gathe r relevant data. Results. Several studies have underscored the pivotal role of mic ro-RNAs in both diagnosing and treating cardiovascular diseases. Notably, elevated leve ls of miRNA-636, miRNA-380, and miRNA-17 have been observed in the plasma of individuals ex periencing acute myocardial infarction (AMI). Additionally, miRNA-126, miRNA-37, and miR-221 show increased levels in heart failure patients. Furthermore, the prognostic effica cy of miRNA-182 surpasses that of natriuretic peptide and high-sensitivity C-reactive protein i n heart failure (HF). Other studies have shown that MiR-499 had a more precise and significantly high er predictive value than the most reliable biomarkers for AMI: c troponin I (cTnI) and creat inkinase MB (CK-MB). In mouse models, intramyocardial injection of vesicles containi ng miRNA-99 has demonstrated a preventive effect on hypoxia-induced apoptosis and promoted autophagy. This i ntervention has resulted in improved left ventricular function and increased survival during four weeks after AMI. Conclusion. Presently, miRNAs have the potential to be employed for dia gnostic and therapeutic purposes in various cardiovascular diseases. They exert their influence on specific cellular pathways or processes through structures like liposomes, ve sicles, or viral vectors designed for intracellular miRNA delivery
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Роль микро-РНК в развитии ожирения
Full text linkRezumat. Introducere. micro-RNA (miRNA) sunt
molecule mici de RNA care joacă un rol important în
controlul expresiei genelor în celulele eucariote.
Actualmente, se consideră că miRNA circulante pot fi
utilizate ca biomarkeri în diagnostic și noi ținte terapeutice
potențiale în obezitate. Scopul studiului. Elucidarea
rolului miRNA în dezvoltarea obezității în scopul
îmbunătățirii diagnosticului, prognosticului și identificării
unor noi ținte terapeutice potențial eficiente. Materiale și
metode. S-a efectuat un reviu al literaturii din ultimii 10
ani, utilizând 26 de surse, inclusiv PubMed, Elsevier,
Cambridge Journals Online, Hinari, Medline, MedScape și
American Physiological Society Journals. Rezultate. Mai
multe studii au evidențiat un rol semnificativ al miRNA în dezvoltarea obezității. De exemplu, eliminarea Dicer, o
enzimă cheie în procesingul miRNA, inhiba diferențierea
adipocitelor și formarea țesutului adipos în timpul
adipogenezei. S-a constatat că nivelul crescut de miR-129-
5p a suprimat adipogeneza și a condus la reducerea
expresiei genelor adipogenezei UCP1, PRDM16 și PPARγ.
Unii compuși chimici, de exemplu betaina, poate
interacționa cu miR-143, influențând dezvoltarea
obezității. A fost remarcat rolul expresiei scăzute a miR-27a
în dezvoltarea apoptozei și, ca urmare, în inflamația
țesutului adipos. Exosomele, mici vezicule extracelulare, și
substanțele chimice, precum antipirenele organofosforice,
pot contribui la patogeneza obezității, influențând expresia
miRNA. De asemenea, a fost observat un rol important al
miR-129-5p, miR-181d, miR-378a, miR-143, miR-452 în
dezvoltarea obezității. Concluzii. Studiile din ultimii ani au
demonstrat influența semnificativă a multor miRNA în
patogeneza obezității. Astfel, miRNA nominalizate pot
servi ca ținte terapeutice potențiale în diferite disfuncții ale
adipogenezei.Introduction. MicroRNAs (miRNAs)
are small RNA molecules that play an important role in
controlling gene expression in eukaryotic cells. Circulating
miRNAs are considered to be potential biomarkers for
diagnosis and new therapeutic targets in obesity. Study
Objective. To elucidate the role of miRNAs in the obesity
development with the aim of improving diagnosis,
prognosis, and identifying new potentially effective
therapeutic targets. Materials and Methods. A literature
review was conducted over the past 10 years, using 26
sources, such as PubMed, Elsevier, Cambridge Journals
Online, Hinari, Medline, MedScape, and the American
Physiological Society Journals. Results. It have been
highlighted the significant role of miRNAs in the obesity
development. Deletion of Dicer, a key enzyme for miRNA
processing, suppressed adipocyte differentiation and
adipose tissue formation during adipogenesis. The
increased levels of miR-129-5p suppressed beige
adipogenesis and reduced the expression of adipogenic
genes UCP1, PRDM16, and PPARγ. Certain chemical
compounds, such as betaine, can interact with miR-143,
influencing obesity development. The role of decreased
expression of miR-27a in apoptosis and, consequently,
inflammation in adipose tissue was noted. Exosomes, small
extracellular vesicles, and chemicals, such as
organophosphorus flame retardants, may contribute to the
obesity pathogenesis by influencing miRNA expression.
Also, an important role of miR-129-5p, miR-181d, miR-
378a, miR-143, miR-452 in the development of obesity has
been noted. Conclusions. Recent studies have
demonstrated the significant impact of many miRNAs on
the obesity pathogenesis. Thus, the nominated miRNAs
may serve as potential therapeutic targets for various
adipogenic dysfunctions.Введение. Микро-РНК (миРНК)
представляют собой малые молекулы
рибонуклеиновой кислоты, которые играют важную
роль в контроле экспрессии генов в эукариотических
клетках. В настоящее время считается, что
циркулирующие миРНК могут использоваться в
качестве биомаркеров для диагностики и новых
потенциальных терапевтических целей при ожирении.
Цель исследования. Раскрытие роли миРНК в
развитии ожирения с целью улучшения диагностики,
прогнозирования и выявления новых потенциально
эффективных терапевтических целей. Материалы и
методы. Был проведен обзор литературы за последние
10 лет, используя 26 источников, включая PubMed,
Elsevier, Cambridge Journals Online, Hinari, Medline,
MedScape и American Physiological Society Journals.
Результаты. Ряд исследований вывили значительную
роль миРНК в развитии ожирения. Например, удаление
Dicer, ключевого фермента для процессинга миРНК,
подавляло дифференцировку адипоцитов и
образование жировой ткани во время адипогенеза.
Также было обнаружено, что повышенные уровни miR-
129-5p подавляли бежевый адипогенез и снижали
экспрессию адипогенных генов UCP1, PRDM16 и
PPARγ. Исследования показали, что некоторые
химические соединения, такие как бетаин, могут
взаимодействовать с некоторыми миРНК, например
miR-143, оказывая влияние на развитие ожирения.
Была отмечена роль пониженной экспрессии миР-27а в
развитии апоптоза и, как следствие, воспаления в
жировой ткани. Экзосомы, небольшие внеклеточные
везикулы и химические вещества, такие как
фосфорорганические антипирены, могут
способствовать патогенезу ожирения, влияя на
экспрессию микроРНК. Также была отмечена важная
роль miR-129-5p, miR-181d, miR-378a, miR-143, miR-
452 в развитии ожирения Выводы. Исследования
последних лет показали значительное влияние многих
миРНК в патогенезе ожирения. Таким образом,
вышеупомянутые миРНК могут выступать в качестве
потенциальных терапевтических мишеней при
различных дисфункциях адипогенеза
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
