3,160 research outputs found
Suppression of erythropoiesis by dietary nitrate
No full textIn mammals, hypoxia-triggered erythropoietin release increases red blood cell mass to meet tissue oxygen demands. Using male Wistar rats, we unmask a previously unrecognized regulatory pathway of erythropoiesis involving suppressor control by the NO metabolite and ubiquitous dietary component nitrate. We find that circulating hemoglobin levels are modulated by nitrate at concentrations achievable by dietary intervention under normoxic and hypoxic conditions; a moderate dose of nitrate administered via the drinking water (7 mg NaNO3/kg body weight/d) lowered hemoglobin concentration and hematocrit after 6 d compared with nonsupplemented/NaCl-supplemented controls. The underlying mechanism is suppression of hepatic erythropoietin expression associated with the downregulation of tissue hypoxia markers, suggesting increased pO2. At higher nitrate doses, however, a partial reversal of this effect occurred; this was accompanied by increased renal erythropoietin expression and stabilization of hypoxia-inducible factors, likely brought about by the relative anemia. Thus, hepatic and renal hypoxia-sensing pathways act in concert to modulate hemoglobin in response to nitrate, converging at an optimal minimal hemoglobin concentration appropriate to the environmental/physiologic situation. Suppression of hepatic erythropoietin expression by nitrate may thus act to decrease blood viscosity while matching oxygen supply to demand, whereas renal oxygen sensing could act as a brake, averting a potentially detrimental fall in hematocrit.—Ashmore, T., Fernandez, B. O., Evans, C. E., Huang, Y., Branco-Price, C., Griffin, J. L., Johnson, R. S., Feelisch, M., and Murray, A. J. Suppression of erythropoiesis by dietary nitrate
Costs and benefits of debt and debt service reduction
No full textThe author evaluates the costs and benefits of debt and debt service reduction (DDSR) from the point of view of five countries that have concluded Brady deals: Costa Rica, Mexico, the Philippines, Uruguay, and Venezuela. He concludes that, contrary to widely held views, commercial banks have probably benefited from the operations. Commercial bank participation in DDSR is voluntary, so direct financial savings to the country are probably negative at present values. The benefit from DDSR is not that debt is bought at"bargain prices"at the expense of commercial banks. It appears difficult to justify a DDSR operation on purely financial grounds. A more realistic way to look at a DDSR operation is to view it as a"project"that involves a certain financial cost. The return on such a project is how the DDSR operation improves the macroeconomy, or contributes to development. The main purpose of DDSR is to establish a more efficient arrangement between debtor countries and commercial banks, leading to improved conditions for development. A DDSR operation that does not help development is costly and should not be undertaken. The impact of DDSR on development is usually measured by the increase in the growth rate of GDP, but it is too soon to measure that for these five countries. A suitable alternative is to look at the change in investment patterns. A strong policy framework is needed if debt and debt service reduction are to significantly improve development. In Mexico and, to a lesser extent, Venezuela, improved and sustained strong adjustment policies have generated the greatest development benefits. Gains have been less in smaller countries where policies were not as supportive. The author concludes that for a country to benefit from DDSR, it needs significant indirect benefits (such as increased domestic and foreign savings). Direct benefits are likely to be negative because of the commercial banks'financial gains and because DDSR operations are frontloaded. DDSR operations cannot be justified solely by direct benefits and savings in cash flow.Strategic Debt Management,Banks&Banking Reform,Economic Theory&Research,Environmental Economics&Policies,Financial Intermediation
Correction to: Eye Movement Desensitization and Reprocessing in Child and Adolescent Psychology: a Narrative Review (Current Treatment Options in Psychiatry, (2021), 8, 3, (95-109), 10.1007/s40501-021-00244-0)
No full textThe original publication of this article contained mistakes and the author would like to correct them. There is an error in the affiliation of author Isabel Fernandez. Isabel Fernandez is not affiliated to Catholic University. She is only affiliated to “Centro di Ricerca e Studi in Psicotraumatologia (C.R.S.P.), Milan, Italy.” The original article has been corrected
Youthhood
No full textTESTING-GROUND issue 03, Youthhood, examines worlds through youthful eyes, makes evident young ambitions, and questions how we can better empower young people to design cities, landscapes, and a planet that works for them. The issue includes contributions from: Carmel Keren, Jude Daniel Smith, Claire Edwards, Kazeem Kuteyi, Emmanuel Adarkwah, Reza Nik, Dan Cui, Kristofer Cullum-Fernandez, Fida Sassi, Simeon Shtebunaev, Daze Aghaji, Averill Dimabuyu, Sarri Elfaitouri, Rebecca McDonald-Balfour, and Ed Wall.
Rebecca McDonald-Balfour (Author), Jude Daniel Smith (Author), Daze Aghaji (Author), Carmel Keran (Author), Alexis Liu (Author), Dan Cui (Author), Kristofer Cullum-Fernandez (Author), Fida Sassi (Author), Averill Dimabuyu (Author), Ed
Recollections of endearment
No full textI am interested in exploring this space of memory through the process of painting and installation. My memory of growing up with the Mexican culture is the lens I use to approach my body of work. I am seeking to create an experiential space through the artwork that has the potential to visually transcend language, culture, and religion. The cultural and religious elements from private and public memorials, shrines, and altars are incorporated into the work. I fuse my interests in the visual exploration with the subjective space of memory, culture and influences from contemporary art. Also, I have used the persuasion of contemporary artists such as Jacqueline Humphries, Charline Von Heyl, Beatriz Milhazes, and Pepon Osorio as an underlying inspiration for much of my work.M.F.A.Includes summaryIncludes bibliographical references (p. 25-26)by Leticia Fernandez Luevano
Título: Da creaçao et composiçao do homem
No full textCopia digital : Google BooksMención de edición precede a "e hum prologo em que conta a vida do author"Sign.: [calderón]\p4\s, 2[calderón]\p8\s, a-e\p8\s, 2a-2e\p8\s, 2f\p2\s, [ ]\p1\s, A\p7\s, B-D\p8\s, E\p4\sPortada con escudo xilográficoCada una de las dos comedias con portada propia, Em Lisboa: Impressa com todas as licenças necessarias por Vicente Aluarez, 1615Los cantos "Da creaçao et composiçao do homem" con portada propia, Em Lisboa: por Pedro Crasbeeck, 1615Port. con esc. xilCada una de las dos comedias con port. propia, Em Lisboa: Impressa com todas as licenças necessarias por Vicente Aluarez, 1615Los cantos "Da creaçao et composiçao do homem" con port. propia, Em Lisboa: por Pedro Crasbeeck, 1615Contiene con portada y paginación propias: Comedia does enfatrioens ; Comedia de Filodemo ; Los cantos "Da creaçao et composiçao do home
L’ÉCRITURE DE L’ITALIE CHEZ DOMINIQUE FERNANDEZ : SACRALISATION D’UN ESPACE PROFANE
No full textItaly in the Writings of Dominique Fernandez: The Sacralization of a Profane Space. For Dominique Fernandez, writing about Italy is associated with a quest for original androgyny. The Italian space supports a return to a primitive existence. Synonymous with freedom and sexual undifferentiation, it allows us to find prelapsarian paradise, where the boundaries between the sexes did not exist. Mircea Eliade’s works follow the same logic. Indeed, the author studies the nostalgia for the origins which incites man to discover the mythical primordial era sanctified by the gods. Hence, this article blends the historical-religious endeavor with the literary approach which, though unable to go back in time, keeps repeating it indefinitely, thanks to the demiurgic power of the writer.
REZUMAT. Italia în scrierile lui Dominique Fernandez: sacralizarea unui spațiu profan. În scrierile lui Dominique Fernandez, Italia este indisociabilă de căutarea androginiei originare. Spațiul italian favorizează, după el, întoarcerea la starea primitivă a existenței. Sinonim al libertății și al nediferențierii sexuale, el permite regăsirea paradisului pierdut dinaintea căderii în păcat, în care limitele între sexe nu există încă. Operele lui Mircea Eliade se înscriu în această logică. Scriitorul studiază « nostalgia originilor » care hrănește, la ființa umană, aspirația de a regăsi timpul mitic și primordial sacralizat de zei. Acest articol împletește un demers istorico-religios cu unul literar, care din cauză că nu poate reveni în timp, încearcă la infinit să-l repete grație puterii demiurgice a scriitorului.
Cuvinte-cheie: Italia, spațiu sacru, spațiu profan, paradis pierdut, scriitur
Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway
No full textInorganic nitrate was once considered an oxidation end-product of nitric oxide metabolism with little biological activity. However, recent studies have demonstrated that dietary nitrate can modulate mitochondrial function in man and is effective in reversing features of the metabolic syndrome in mice. Using a combined histological, metabolomics, and transcriptional and protein analysis approach we mechanistically define that nitrate not only increases the expression of thermogenic genes in brown-adipose tissue but also induces the expression of brown adipocyte-specific genes and proteins in white adipose tissue, substantially increasing oxygen consumption and fatty acid ?-oxidation in adipocytes. Nitrate induces these phenotypic changes through a mechanism distinct from known physiological small molecule activators of browning, the recently identified nitrate-nitrite-nitric oxide pathway. The nitrate-induced browning effect was enhanced in hypoxia, a serious co-morbidity affecting white adipose tissue in obese individuals, and corrected impaired brown adipocyte-specific gene expression in white adipose tissue in a murine model of obesity. Since resulting beige/brite cells exhibit anti-obesity and anti-diabetic effects, nitrate may be an effective means of inducing the browning response in adipose tissue to treat the metabolic syndrome
Regenerating Nerve Fiber Innervation of Extraocular Muscles and Motor Functional Changes Following Oculomotor Nerve Injuries at Different Sites
No full textTitle: Regenerating nerve fiber innervation of extraocular muscles and motor functional changes following oculomotor nerve injuries at different sites
Author(s): Zhang Wenchuan; Visocchi Massimiliano; Fernandez Eduardo
NEURAL REGENERATION RESEARCH Volume: 6 Issue: 26 Pages: 2032-2036 DOI: 10.3969/j.issn.1673-5374.2011.26.006 Published: SEP 15 2011
In the present study, the oculomotor nerves were sectioned at the proximal (subtentorial) and distal (superior orbital fissure) ends and repaired. After 24 weeks, vestibulo-ocular reflex evaluation confirmed that the regenerating nerve fibers following oculomotor nerve injury in the superior orbital fissure had a high level of specificity for innervating extraocular muscles. The level of functional recovery of extraocular muscles in rats in the superior orbital fissure injury group was remarkably superior over that in rats undergoing oculomotor nerve injuries at the proximal end (subtentorium). Horseradish peroxidase retrograde tracing through the right superior rectus muscle showed that the distribution of neurons in the nucleus of the oculomotor nerve was directly associated with the injury site, and that crude fibers were badly damaged. The closer the site of injury of the oculomotor nerve was to the extraocular muscle, the better the recovery of neurological function was. The mechanism may be associated with the aberrant number of regenerated nerve fibers passing through the injury site
International Immigration ： A Reply to Gabriel Palmer-Fernandez and Julie Kirsch
No full textAmong the various issues in Global Justice that I address in Morality and Global Justice: Justifications and Applications (2011-a), international immigration is one of the most important. Gabriel Palmer-Fernandez and Julie Kirsch have written sensitive queries about my position that I will address in order .Author Meets the Critics:
Michael Boylan’s Morality and Global Justice
Introductory Note
The following exchange occurred at 21st Annual meeting of the
Association for Professional and Practical Ethics held on March 1-4,
2012, in Cincinnati, Ohio. The session was an author meets critics
session on Boylan's 2011 book published by Westview Press, Boulder,
Colorado. The topic of the discussion is a controversial treatment of
immigration by Boylan in his chapter on immigration.
The critics were: Gabriel Palmer-Fernandez and Julie E. Kirsch, who
provide critical assessments of Boylan’s claims. Boylan then offers a
reply to their arguments
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