25 research outputs found
Autoimmune bullous diseases in non-HIV Kaposi's sarcoma : a retrospective study in a large cohort of patients
No full textBackground: Kaposi's sarcoma (KS) is a rare endothelial neoplasm caused by the human herpesvirus 8 (HHV-8). Its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for autoimmune bullous diseases. Conversely, HHV-8 infection has been hypothesized to be a triggering factor of bullous diseases, especially pemphigus. Given the fact that both KS and autoimmune bullous diseases have a low incidence in the general population, it could be expected that the association between these disorders would be exceptional. Objectives: To assess the frequency of bullous diseases in a large cohort of non-HIV KS patients and to describe our experience concerning the clinical features, natural history and treatment options in this setting. Methods: We performed a retrospective review of all patients with non-HIV KS in association with bullous disease followed at our department between 1990 and 2016. Medical records were reviewed for demographics, medical history, clinical characteristics and treatment. Results: Among 1362 patients with classic or iatrogenic KS, 14 (1.03%) also suffered from bullous disease. The mean age at diagnosis of both disorders was 85.8 years with a male/female ratio of 9: 5. Among these 14 cases, nine (0.66%) were associated with bullous pemphigoid (BP), three (0.22%) with localized BP and two (0.15%) with pemphigus vulgaris. Seven had developed a bullous disease after being diagnosed with KS, while in the remaining seven cases, KS developed after the onset of bullous disease. As expected, KS worsened when corticosteroids were used. Conclusion: Bullous diseases seem to be more frequent among patients with KS, supporting the hypothesis that HHV-8 may be involved in their pathogenesis. Therapeutic management of these cases should take into account KS-inducing potential of corticosteroids
Treatment of classic Kaposi sarcoma with a nicotine dermal patch: a phase II clinical trial
No full textBackground: Kaposi sarcoma (KS), a malignancy of dermal endothelial cells that is caused by human herpesvirus 8 (HHV8) infection, is sensitive to perturbations of immunity. Nicotine might be effective against KS because of its immunologic and vascular effects and because smoking is associated with a low risk of KS. Objective and study design: We conducted a masked, randomized phase 2 clinical trial of transdermal nicotine and placebo patches to assess the safety and efficacy of nicotine against classic KS (cKS). Subjects and methods: Three cKS lesions, predominantly nodules, in each of 24 non-smoking patients were randomly assigned to 15 weeks continuous treatment with nicotine patch (escalated to 7 mg), identical masked placebo patch or no patch. Changes in lesion area and elevation from baseline through six follow-up visits, by direct measurement and by two independent readers using digital photographs of the lesions, were compared using non-parametric and regression methods. Changes in longitudinal levels of HHV8 antibodies and DNA in blood cells were similarly assessed. Results: There were no systemic or serious adverse events, and compliance was good. One patient resumed smoking and discontinued patches, and two patients withdrew at week 12 for unrelated indications. Six (29%) of the remaining 21 suspended use of patches to relieve local skin irritation; four of these six completed the trial at reduced dose. Treatment assignment was not associated with significant or consistent changes in cKS lesion area or elevation, HHV8 viral load or antibodies. Conclusion: Transdermal nicotine and placebo patches caused no serious toxicities but had no demonstrable effect on nodular cKS lesions or HHV8 levels
Coltura e caratterizzazione degli elementi endoteliali circolanti nel sangue periferico di pazienti con Sarcoma di Kaposi classico
No full textThe New Role of 'Host Countries' Played by Traditional Countries of Emigration: The Experience of Italy
No full textThe objective of this article is to argue
that in order to successfully address the
issue of integration of migrants, both
voluntary and involuntary, countries
need to abandon concepts of nation-state
and nationalism and embrace policies
of multiculturalism and active
citizenship. The article specifically
deals with new immigrant-receiving
countries and provides the example of
Italy where new policies have been
adopted to deal with the integration of
newcomers. Despite these efforts, hurdles
are still present in the Italian immigration
system. Nonetheless, it must be
acknowledged that the approach espoused
by Italy towards immigration is
positive in that it favours integration
without total assimilation. The Italian
approach reflects the multiculturalism
policy framework adopted by Canada,
which in the opinion of this author is
still the most successful policy model in
addressing issues of integration and
diversity.Le but de cet article est de proposer que si les états veulent pouvoir gérer avec succès la question de l'intégration d'immigrants, volontaires et non-volontaires, ils doivent abandonner les concepts d'état nation et de nationalisme et adopter résolument des politiques de multiculturalisme et de citoyenneté active. L'article traite spécifiquement du cas de nouveaux pays d'accueil des immigrants, et fournit l'exemple de l'Italie où de nouvelles politiques ont été adoptées pour s'occuper de l'intégration de nouveaux arrivés. En dépit de ces efforts, il reste encore des obstacles dans le système italien d'immigration. On doit cependant reconnaître que l'approche adoptée par l'Italie vis-à-vis de la question de l'immigration est positive en ce qu'elle favorise l'intégration sans toutefois aller jusqu'à l'assimilation totale. L'approche italienne reflète la politique-cadre multi-culturelle adoptée par le Canada, qui reste toujours, selon l'auteur, le modèle de politique ayant le plus de succès pour s'adresser aux questions d'intégration et de diversité
Mogadiscio tra rovine e globalizzazione
No full textIn questo articolo, l'autore descrive i cambiamenti che Mogadiscio ha subito negli anni successivi allo scoppio della guerra civile nel 1991.Qoraagu wuxuu maqaalkaan uga faalloonayaa isbeddelka ku dhacay magaalada Muqdisho sannadihii ka dambeeyey dagaalkii sokeeye.In this article, the author describes the changes that Mogadishu has undergone in the years following the outbreak of civil war in 1991
Mogadiscio
No full textL'autore, giornalista italiano in Somalia, ripercorre la storia recente del paese fino allo scoppio della guerra civile.Qorahani, oo ah weriya taliyaani, wuxuu ka hadlayaa taariikhda dalka soomaaliyeed ee dhow ilaa xilliga dagaalka sokeeye.The author, an Italian journalist in Somalia, traces the recent history of the country until the outbreak of civil war
Mogadiscio dans la guerre civile: rêves d'Etat
No full textQoraagu wuxuu ka hadlayaa dowrka ay ka qaadatay caasimadda Moqdisho dhibaatooyinka dalka ku habsaday kaddib markii ay qarxeen dagaalladii sokeeye 1991.L'autore riflette sul ruolo della capitale somala, Mogadiscio, e sulla relativa evoluzione subita in seguito alla crisi che attraversa il paese dallo scoppio della guerra civile nel 1991.The author reflects on the role of the Somali capital, Mogadishu, and its evolution in relation to the crisis the country is facing since the outbreak of the civil war in 1991
Does Oxidative Stress Play a Role in the Pathogenesis of Urticarias?
No full textRadical oxygen species (ROS) modulate various cellular processes and are involved in physiologic and pathologic conditions, including inflammation. There is growing evidence that supports the existence of an abnormal redox status in some chronic inflammatory skin diseases, including contact dermatitis, atopic dermatitis and psoriasis. This review introduces some general aspects on the role of oxidative stress in cutaneous inflammation, with special emphasis on urticarias, summarizing recent novel findings derived from the study of physical urticarias and chronic idiopathic urticaria
Miłość w czasach wojny w nowelach Federica De Roberta: «La Cocotte» i «L’Ultimo Voto»
No full textFederico De Roberto, the author of the "Viceroys" known and appreciated by contemporary readers, dedicates a significant part of his texts to "love case studies". Love is not only the subject of his prose, but also the subject of tractates, thanks to which the author intends to find out the "truth" about feelings. In his war short stories, the author returns to the topic, “La Cocotte” and “L’Ultimo Voto” are studies of love during the First World War. The aim of the article is to analyze the role of literary space and characters in depicting the conflict between love for a woman and patriotic feelings. Federico De Roberto (1861–1927), autore dei «Viceré», è uno dei più importanti narratori siciliani. Nei primi anni della sua attività letteraria il riconoscimento da parte degli autori veristi garantisce al giovane scrittore una certa attenzione dei lettori. Col passare del tempo, però, egli viene considerato un epigono dei veristi, un letterato ottocentesco, le cui opere non attingono alle maggiori tendenze letterarie del primo Novecento. Non condivide l’interesse per i movimenti rinnovatori della letteratura italiana dell’epoca, tra cui i futuristi e la loro fascinazione per la modernità e la guerra; lo scrittore catanese assume una posizione antitetica nei loro confronti e così, all’indomani dello scoppio della Prima Guerra Mondiale, si dichiara a favore dell’anti-interventismo.Federico De Roberto, autor znanych i docenianych przez współczesnych czytelników „Wicekrólów”, znaczną część swoich tekstów poświęcił “studiom przypadków miłosnych”. Miłość jest tematem nie tylko prozy, ale również przedmiotem traktatów, dzięki, którym autor ma zamiar dotrzeć do „prawdy” o uczuciach. W opowiadaniach wojennych autor powraca do tych poszukiwań, «La Cocotte» i «L’Ultimo Voto» to studia miłości w czasach Pierwszej Wojny Światowej. Materia literacka, przestrzeń i bohaterowie, służy do zobrazowania konfliktu między miłością do kobiety, a uczuciami patriotycznymi
The role of foreign collections of Somalia in preserving and rebuilding the Somali national heritage
No full textWith the broke out of the war in 1991 in Somalia, many institutions and sites have been destroyed, with them libraries and cultural material. In this paper, the author of foreign collections of Somali documents and material and underlines the significant role they can play in preserving and rebuilding the Somali national heritage.Dagaalkii ka dhacay Soomaaliya 1991 waxaa burburay dhammaan hay'adihii, xarumo badan iyo maktabadahooda iyo macluumaad badan oo la xiriira dhaqanka oo la kaydiyay. Qoraagu wuxuu maqaalkan ku sahminayaa macluumaadkaas dhaqameed ee shisheeyuhu uu ururiyay, wuxuuna hoosta ka xarriiqayaa in kuwaasi ay qayb ka qaadan karaan dib u ururinta iyo xifdinta hiddaha iyo dhaqanka Soomaaliyeed.Con lo scoppio della guerra in Somalia nel 1991, molte istituzioni e molti siti sono stati distrutti, e insieme a loro biblioteche e il relativo materiale culturale conservato. In questo articolo, l'autore fa una ricognizione delle collezioni straniere di documenti e materiale relativi alla Somalia e sottolinea il ruolo che potrebbero assumere nella salvaguardia e ricostruzione del patrimonio nazionale somalo.Paper presented to the 1st Conference of the European Association of Somali Studies, London, SOAS.Qoraalkan waxaa lagu soo bandhigay Shirweynihii koowaad ee Daraasaadka Soomaaliyeed ee Ururka Yurub, London, SOAS.Articolo presentato alla Prima Conferenza dell'Associazione Europea di Studi Somali, Londra, SOAS
