178,772 research outputs found
Yi Min Cai's Graduate Recital
No full textOriginal Format: CassetteComposers in the first graduate recital: J. S. Bach; Gail Barber; E. Granados; J. B. Krumpholz; Claude Debussy; Marcel GrandjanyComposers in the second graduate recital: J. Massenet; Gabriel Faure; W. A. MozartFirst Recital: HarpSecond Recital: Har
Min-Jeong Lee
No full text학위논문(석사)--아주대학교 일반대학원 :의학과,2014. 8“신대체요법을 언제 시작해야 하는가?”란 물음에 답하는 것은 어려운 일이다. 신대체요법이 임박한 말기신장질환 환자에서 언제 투석을 시작할지에 대한 결정을 돕기 위하여, 본 연구에서는 한국 3차 의료기관에서 혈액투석 시작 시점에서의 말기신장질환 환자의 임상적 특징을 분석하고자 한다. 2010년 1월부터 2012년 12월까지 처음 혈액투석을 시작한 409명의 환자를 후향적으로 분석하였다. 말기신부전의 가장 흔한 원인은 당뇨병성신증 (48.7%) 였으며, 두 번째로 흔한 원인은 조직검사로 증명된 사구체신염 (11.7%)이었다. 혈액투석 시작 시점에서의 사구체 여과율은 5.59 ~ 7.82 ml/min/1.73m2 였다 (Nankivell equation 으로 계산한 사구체 여과율 제외). 이러한 사구체 여과율은 사구체 여과율 계산 공식을 어떤 것을 사용하는가에 따라 통계학적으로 유의한 차이가 있었다 (p ≤ 0.002). 다섯 가지의 사구체 여과율 공식 중에서, Modified Cockcroft-Gault 식, MDRD 식과 CKD-EPI 식이 만성신부전 합병증과 유의한 상관관계를 보였다. 특히 Modified Cockcroft-Gault 식의 경우 변동 계수(CV; coefficient of variation)가 가장 작았으며, 이는 이 식이 본 연구의 환자들의 eGFR 값을 가장 재현성 있게 나타낸다는 것을 의미한다. 혈액투석을 시작하게 된 주된 이유는 부종 (38.4%), 요독 증세 (35.0%) 였다. 당뇨 환자는 비당뇨 환자에 비하여 더 나이가 많고, 투석 시작시 높은 사구체 여과율을 보였다. 59.2% 의 환자는 외래를 경유하여 혈액투석을 시작하였고, 40.8% 의 환자는 응급실로 내원하여 혈액투석을 시작하였다. 응급실로 내원하여 투석을 시작한 경우, 고칼륨혈증 및 대사성 산증이 외래 내원하여 시작한 환자군에 비하여 더 심한 소견을 보였다. 현재 한국에서 행해지고 있는 혈액 투석 시작 시점에서의 말기신장질환 환자들의 임상적 특징 및 혈액검사 자료 등의 자료가 향후 투석 시작 시점을 결정하는데 유용한 정보가 되길 기대한다.ABSTRACTS
LIST OF FIGURES
LIST OF TABLES
I. INTRODUCTION
II. METHODS
A. Patient selection
B. Laboratory data
C. Estimated glomerular filtration rate
D. Statistical analysis
III. RESULTS
IV. DISCUSSION
REFERENCES
FIGURES
TABLES
국문요약Maste
Author Correction: Human fingerprint in global weather
No full textIn the version of this News & Views originally published, the ref. 5 author surnames Meihnausen, Fisher and Szekely were spelled incorrectly; they should have been spelled Meinshausen, Fischer and Székely, respectively. This has now been corrected. © 2020, Springer Nature Limited.11Nsciessciscopu
Genome-wide landscape of alternative splicing events in brachypodium distachyon
No full textRecently, Brachypodium distachyon has emerged as a model plant for studying monocot grasses and cereal crops. Using assembled expressed transcript sequences and subsequent mapping to the corresponding genome, we identified 1219 alternative splicing (AS) events spanning across 2021 putatively assembled transcripts generated from 941 genes. Approximately, 6.3% of expressed genes are alternatively spliced in B. distachyon. We observed that a majority of the identified AS events were related to retained introns (55.5%), followed by alternative acceptor sites (16.7%).We also observed a low percentage of exon skipping (5.0%) and alternative donor site events (8.8%). The 'complex event' that consists of a combination of two or more basic splicing events accounted for ~14.0%. Comparative AS transcript analysis revealed 163 and 39 homologous pairs between B. distachyon and Oryza sativa and between B. distachyon and Arabidopsis thaliana, respectively. In all, we found 16 AS transcripts to be conserved in all 3 species. AS events and related putative assembled transcripts annotation can be systematically browsed at Plant Alternative Splicing Database (http://proteomics.ysu.edu/altsplice/plant/). © The Author 2012
Immunoprophylaxie des cancers colorectaux par des glucides indigestibles fermentables : études chez la souris Min
No full textCertaines fibres alimentaires réduiraient l'apparition des cancers colorectaux mais l'hypothèse reste controversée. Un des mécanismes fait intervenir la production par fermentation de butyrate. Nous avons testé deux fibres butyrogènes chimiquement différentes (fructo-oligosaccharides à chaîne courte scFOS, et amidon résistant) versus une fibre faiblement productrice de butyrate (son de blé désamidonné) chez la souris Min, un modèle de carcinogenèse intestinale spontanée. Seul le régime scFOS réduisait le nombre de tumeurs coliques et stimulait l'immunité locale. La nature chimique de la fibre ou bien les propriétés prébiotiques des scFOS (ils favorisent la croissance de bactéries lactiques qui agiraient sur la réaction immunitaire) sont donc impliquées. Deux autres types d'amidons résistants réduisaient le nombre de petites tumeurs. L'addition de bifidobactéries à l'un de ces deux régimes réduisait le nombre de petites tumeurs, mais augmentait celui de grosses tumeurs illustrant le concept de modulation par l'immunogénicité de la dualité immunofacilitation surveillance. La déplétion en lymphocytes T associée au régime scFOS doublait le nombre de tumeurs par rapport aux
souris immunocompétentes. Le régime scFOS diminuait l'expression du récepteur à l'IL2 à la surface des lymphocytes intra-épithéliaux (LIE) suggérant la mise en anergie temporaire du système immunitaire, mais pouvant aussi signifier l'implication d'une autre voie d'activation des LIE. Enfin, pour mettre en place une modélisation des intéractions lympho-épithéliales, nous avons croisé des
souris C57BL6 et Min avec la souris transgénique Immortomouse et isolé à partir de primo-cultures
de muqueuses des lignées cellulaires conditionnellement immortalisées saines et mutées sur Apc. Ce modèle permettra d'étudier en co-culture sur filtre, l'influence des glucides indigestibles et de leurs produits de fermentation sur les interactions lympho-épithéliales au cours de la carcinogenèse
Investigating the jet activity accompanying the production at the LHC of a massive scalar particle decaying into photons
No full textWe study the jet activity that accompanies the production by gluon fusion of a new physics scalar particle decaying into photons at the LHC. In the considered scenarios, both the production and decay mechanisms are governed by loop-induced interactions involving a heavy colored state. We show that the presence of large new physics contributions to the inclusive diphoton invariant-mass spectrum always implies a significant production rate of non-standard diphoton events containing extra hard jets. We investigate the existence of possible handles that could provide a way to obtain information on the underlying physics behind the scalar resonance, and this in a wide mass window. © 2016 The Author(s)4411Nsciescopu
Effects of annealing process on magnetic properties and structures of Nd-Pr-Ce-Fe-B melt-spun powders
No full textThe effects of annealing process on magnetic properties and structures of Nd-Pr-Ce-Fe-B melt-spun powders have been investigated. The magnetic properties improve a lot when the annealing temperature is 590-650 degrees C and the annealing time exceeds 1 min. The magnetic properties is stable when the annealing time is 590-650 degrees C. The powders contains obvious grains when the annealing time is only 1 min, while the grains grow up obviously, leading to the decrease of B-r and (BH)(max), when the annealing time is more than 9 min. The H-cj changes little for different annealing time. The cooling rate also affects the magnetic properties of powders with different Ce-content. Faster cooling rate is favorable to improve magnetic properties with low Ce-content powders, while high Ce-content powders need slower cooling rate. (C) 2016 Elsevier B.V. All rights reserved
General fuzzy min-max neural network for clustering and classification
No full textThis paper describes a general fuzzy min-max (GFMM) neural network which is a generalization and extension of the fuzzy min-max clustering and classification algorithms of Simpson (1992, 1993). The GFMM method combines supervised and unsupervised learning in a single training algorithm. The fusion of clustering and classification resulted in an algorithm that can be used as pure clustering, pure classification, or hybrid clustering classification. It exhibits a property of finding decision boundaries between classes while clustering patterns that cannot be said to belong to any of existing classes. Similarly to the original algorithms, the hyperbox fuzzy sets are used as a representation of clusters and classes. Learning is usually completed in a few passes and consists of placing and adjusting the hyperboxes in the pattern space; this is an expansion-contraction process. The classification results can be crisp or fuzzy. New data can be included without the need for retraining. While retaining all the interesting features of the original algorithms, a number of modifications to their definition have been made in order to accommodate fuzzy input patterns in the form of lower and upper bounds, combine the supervised and unsupervised learning, and improve the effectiveness of operations. A detailed account of the GFMM neural network, its comparison with the Simpson's fuzzy min-max neural networks, a set of examples, and an application to the leakage detection and identification in water distribution systems are given
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