62 research outputs found
La trasposizione del flessore superficiale del 4° dito pro flessore profondo del 2° o del 3° o del flessore lungo del pollice nel trattamento delle lesioni tendinee inveterate. Comunicazione 40° Congresso Società Italiana Chirurgia Mano
No full textLa trasposizione del flessore superficiale del 4° dito pro-flessore profondo del 2°, del 3° o del flessore lungo del pollice nel trattamento delle lesioni tendinee inveterate
No full textNew pathogenetic interpretations and proposals for treatment of acute functional acrosyndromes
No full textChanges in exercise endurance and inspiratory capacity after lumacaftor/ivacaftor therapy in cystic fibrosis
No full text1959, Jan.-Aug. -- Correspondence, Unsorted -- letter, 1959-06-09
No full textLetter from Seitelberger, F. to Messore, Giacomo dated 1959-06-09.Sabin Collection Fair Use Policy</a
Toxicological aspects of cannabinoid, pesticide and metal levels detected in light Cannabis inflorescences grown in Italy
No full textRecently, the cultivation of light Cannabis, with a total THC content less than 0.6%, has been encouraged due to its industrial and therapeutic potential. This has increased the consumption of hemp for both smoking purposes and food preparation. Even so, Cannabis inflorescences are not subject to EU regulations and standards provided for food and tobacco products. A study was carried out on thirty-one inflorescences samples, collected in different Italian regions, in order to determine cannabinoids, pesticides and metals and to evaluate the exposure of consumers to contaminants and ensure a safe consumption. Contents of THC were always below 0.5%, while CBD ranged between 0.3 and 8.64%. The determination of 154 pesticides showed that 87% of the samples contained fungicides and insecticides in the range 0.01-185 μg/g. The most found are spynosad and cyprodinil. The concentration of metals ranged from 1 to more than 100 μg/g, and As, Cd, Co, Cr, Hg, Cu, Mo, Ni and V exceeded the regulatory US limits for inhaled Cannabis products, while Pb exceeded them for both oral and inhaled products. These contaminants are intrinsically toxic and may affect public health. Actions are needed to establish regulatory measures and reduce the adverse effects caused by contaminants in Cannabis
Treatment compliance in cystic fibrosis patients with chronic Pseudomonas aeruginosa infection treated with tobramycin inhalation powder : The FREE study
No full textBackground: A high treatment burden with nebulised therapies in cystic fibrosis (CF) patients is the major limitation for treatment compliance; moreover, studies on treatment compliance with inhaled antibiotics are limited. This study assessed compliance to TOBI® PodhalerTM (TIP) treatment in CF patients with chronic Pseudomonas aeruginosa (Pa) infections in a real-world setting using the Italian Treatment Adherence CF Questionnaire (ITA-CFq). Methods: This longitudinal, multicentre, cohort study included 2 follow-up (FU) visits: FU-1 at 3-months±15-days from the baseline visit and FU-2 at the end of third TIP cycle (or 6-months after enrolment, whichever occurred first). The effect of TIP on quality-of-life (QoL) and treatment satisfaction were evaluated using Cystic Fibrosis Questionnaire-Revised (CFQ-R) and Treatment Satisfaction Questionnaire for Medication (TSQM), respectively. Overall compliance to treatments was assessed using ITA-CFq. Results: Eighty-two patients (mean age, 24.8 ± 7.9 years), including 22 paediatric patients (age, <18 years), were enrolled in the study; 56 (68.3%) patients, including 17 paediatric patients, completed the study. At baseline, the mean compliance score to aerosol antibiotic treatment was 7.8 ± 3.2; upon introducing TIP, the compliance score improved to 9.4 ± 1.2 at the FU-1 and thereafter remained stable at 9.5 ± 1.2. TSQM was higher for the convenience domain (74.2 ± 17.1 at enrolment and slightly improved to 77.8 ± 15.9 at FU-2) following TIP initiation. No substantial effect of TIP was observed on the QoL when measured using the revised CFQ-R. The safety profile was in line with previous findings. Conclusion: TIP was convenient to use and led to improved treatment adherence in CF patients with chronic Pa-infection
An overview of international literature from cystic fibrosis registries. Part 4: Update 2011.
No full textA total of 53 national cystic fibrosis (CF) patient registry studies published between July 2008 and November 2011 have been reviewed, focusing on the following topics: CF epidemiology, nutrition, microbiology, clinical complications, factors influencing diagnosis and lung disease, effects of socioeconomic status, therapeutic strategy evaluation, clinical trial methodology. The studies describe the clinical characteristics of CF patients, the incidence and prevalence of disease and role of gender gap, as well as the influence of socioeconomic status and environmental factors on clinical outcomes, covering a variety of countries and ethnic groups. Original observations describe patients as they get older, with special reference to the adult presentation of CF and long-term survival. Methodological aspects are discussed, covering the design of clinical trials, survival analysis, auxometry, measures of quality of life, follow up of lung disease, predictability of disease progression and life expectancy. Microbiology studies have investigated the role of selected pathogens, such as Burkholderia species and MRSA. Pulmonary exacerbations are discussed both as a factor influencing morbidity and an endpoint in clinical trials. Finally, some studies give insights on complications, such as CF-related diabetes and hemoptysis, and emerging problems, such as chronic nephropathy
An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea.
No full textExploring metallophore-antibiotic conjugates as a novel antimicrobial strategy that exploits Pseudomonas aeruginosa zinc dependence
No full textPseudomonas aeruginosa (PA) is a ubiquitous Gram-negative bacterium. Pulmonary infections caused by PA represent a serious threat, especially to patients with cystic fibrosis (CF). This risk is further exacerbated by the increasing spread of bacterial strains that show antibiotic resistance1. The ease with which PA can colonize the respiratory tract depends on its ability to proliferate even in environments where essential metals (such as Zn) are present in low concentration. In particular, zinc plays a fundamental role, as it is present in many bacterial proteins crucial for virulence. A peculiar tactic of PA to obtain zinc involves the secretion of pseudopaline (Fig. 1), that is a low molecular weight zinc chelating molecule, capable of binding zinc present in the external environment, extracting it also from proteins present in the host, and deliver it inside the bacterial cell2. The mechanism by which the zinc pseudopaline complex is transported into the bacterial cell has not yet been completely defined. The use of pseudopaline to chelate zinc represents a potential vulnerability of the pathogen, which can be exploited to allow antibiotics to enter the cell via the Trojan horse approach3. The aim of this study is to synthesize simplified analogs of pseudopaline, to evaluate the minimal structural requirements needed to participate in the zinc transport process of PA. These simplified zincophore compounds, simpler to synthesize than pseudopaline, can be more easily conjugated to various antibiotics that are still in use and active against these PA (such as aztreonam or ampicillin), to facilitate their entry into the bacterial cell through a preferential pathway. The antibacterial activity of these conjugates is evaluated against different PA strains to confirm the involvement of the zinc recovery pathway and demonstrate the proof of concept of the Trojan horse approach
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