1,720,959 research outputs found
A phase I-II trial of gefitinib (IRESSA) and radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck (SCCHN)
No full textBackground: Gefitinib, an orally active epidermal growth factor receptor
(EGFR) tyrosine kinase inhibitor, induces growth arrest in SCCHN
cell lines mainly by blocking cells in G1 and preventing them from
entering the cell cycle. Clinical studies have demonstrated the activity of
gefitinib monotherapy in SCCHN. Preclinical studies have shown that the
combination of RT and drugs interfering with the EGF pathway may result
in radiosensitization in squamous cell carcinomas that over express EGFR.in radiosensitization in squamous cell carcinomas that over express EGFR.
Methods: Pts with histologically confirmed, newly diagnosed, locally
advanced inoperable SCCHN, never pretreated with surgery, chemotherapy
or RT were enrolled into a phase I-II trial of gefitinib and RT. Two doses of
gefitinib were tested (250 and 500 mg/day) in the dose-escalation phase
and continued for up to 12 months; RT was administered concomitantly
according to standard procedures (minimum of 52.0 grays; boost to the
primary tumor site up to at least 64.0 grays). The recommended dose of
gefitinib for phase II was determined by the dose-limiting toxicities (DLTs)
observed during its combined administration with RT and for 2 weeks
thereafter (phase I). Activity was evaluated 4 weeks after the end of the
combined treatment and every 8 weeks thereafter, according to RECIST
criteria.
Results: 12 pts (9 M, 3 F, median age 58) have been evaluated thus far.
The most common primary tumor site was the hypopharynx (5 cases); TNM
stage was IV A (10 pts) and IV B (2 pts); tumor grades were 1 (2 pts), 2
(6 pts) and 3 (4 pts). All pts completed the combined treatment according to
the protocol. Total radiation dose was 60-74 grays. Overall best response
was complete response in 3 pts, partial response in 5 pts, and unconfirmed
partial response in 1 pt; 3 pts were not evaluable. Gefitinib-related grade 3
toxicities were mucositis (n = 1), liver toxicity (n = 1). RT-related grade 3
toxicities were stomatitis/mucositis (n =5), general health deterioration
(n = 1). Three pts died during treatment with gefitinib alone (not considered
treatment related). DLT occurred in 3 pts treated with gefitinib 500 mg
(grade 3 stomatitis, 3 pts [RT-related]; grade 3 ALT increased, 1 pt [gefitinibrelated]),
and therefore 250 mg was selected as the recommended gefitinib
dose for phase I1.
Conclusion: Accrual is continuing in the phase II trial. More mature data
will be presented
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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