3 research outputs found
Portland Lives Up to the Hype
No full textBrief review of the attractions of Portland, seen through a national lens. Portland-promoting quotes from national publications such as Conde Nast Traveler and GQ are supported by author B. K.\u27s observations on the city\u27s style and culture. (Number 163 of this issue\u27s 200 Reasons to Love Maine.
New Bahamian records for Laemophloeidae (Coleoptera: Cucujoidea)
No full textA recent collecting trip to Andros Island in the Bahamas yielded a number of new Bahamian records for the Laemophloeidae. Unless otherwise stated specimens representing the new records were collected in ultraviolet light traps in a hardwood coppice at Forfar Field Station during the period 2-7-VI-2001 by the author, B. K. Dozier, and R. H. Turnbow, and are deposited in the Florida State Collection of Arthropods. Forfar Field Station is located on the east coast of the north island, near the small town of Stafford Creek
RNA-sequencing reveals that STRN, ZNF484 and WNK1 add to the value of mitochondrial MT-COI and COX10 as markers of unstable coronary artery disease
No full textMarkers in monocytes, precursors of macrophages, which are related to CAD, are largely unknown. Therefore, we aimed to identify genes in monocytes predictive of a new ischemic event in patients with CAD and/or discriminate between stable CAD and acute coronary syndrome. We included 66 patients with stable CAD, of which 24 developed a new ischemic event, and 19 patients with ACS. Circulating CD14+ monocytes were isolated with magnetic beads. RNA sequencing analysis in monocytes of patients with (n = 13) versus without (n = 11) ischemic event at follow-up and in patients with ACS (n = 12) was validated with qPCR (n = 85). MT-COI, STRN and COX10 predicted new ischemic events in CAD patients (power for separation at 1% error rate of 0.97, 0.90 and 0.77 respectively). Low MT-COI and high STRN were also related to shorter time between blood sampling and event. COX10 and ZNF484 together with MT-COI, STRN and WNK1 separated ACS completely from stable CAD patients. RNA expressions in monocytes of MT-COI, COX10, STRN, WNK1 and ZNF484 were independent of cholesterol lowering and antiplatelet treatment. They were independent of troponin T, a marker of myocardial injury. But, COX10 and ZNF484 in human plaques correlated to plaque markers of M1 macrophage polarization, reflecting vascular injury. Expression of MT-COI, COX10, STRN and WNK1, but not that of ZNF484, PBMCs paired with that in monocytes. The prospective study of relation of MT-COI, COX10, STRN, WNK1 and ZNF484 with unstable CAD is warranted.sponsorship: This work was funded by the Bijzonder Onderzoeksfonds of the KU Leuven (PF/10/014; Centre of Excellence), by the University of Padova (CPDA139317), and by Cariplo foundation (2016-1006), Italian Ministry of Health (GR-2011-02346845), AIRC (IG 2015 Id.17773), Agenzia Nazionale di Valutazione del Sistema Universitario e della Ricerca (ANVUR) (FFABR-2017), and by grants from the Competitive Research Funding of the Tampere University Hospital (Grant 9M048 and 9N035 for T.L.), the Emil Aaltonen Foundation (T. L.), the Pirkanmaa Regional Fund of the Finnish Cultural Foundation, the Research Foundation of Orion Corporation, the Jenny and Antti Wihuri Foundation, and the Academy of Finland Grant no. 104821), the Finnish Foundation for Cardiovascular Research, the Yrjo Jahnsson Foundation and European Union 7th Framework Program, grant number 201668, AtheroRemo and EU Horizon 2020 (grant 755320 for TAXINOMISIS). P.S. and M.V. are researchers of the Research Foundation Flanders. The funding organizations had no role in design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Bernward Klocke is employed by Intrexon Bioinformatics Germany which was hired by KU Leuven to deliver service in modeling. Intrexon Bioinformatics Germany provided support in the form of salary for author B. K., but did not have any additional role in the study design, data collection, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the `author contributions' section. (Bijzonder Onderzoeksfonds of the KU Leuven|PF/10/014, University of Padova|CPDA139317, Cariplo foundation|2016-1006, Italian Ministry of Health|GR-2011-02346845, AIRC|17773, Agenzia Nazionale di Valutazione del Sistema Universitario e della Ricerca (ANVUR) (FFABR-2017), Tampere University Hospital|9M048, Tampere University Hospital|9N035, Emil Aaltonen Foundation, Pirkanmaa Regional Fund of the Finnish Cultural Foundation, Research Foundation of Orion Corporation, Jenny and Antti Wihuri Foundation, Academy of Finland|104821, Finnish Foundation for Cardiovascular Research, Yrjo Jahnsson Foundation, European Union 7th Framework Program|201668, EU Horizon 2020|755320)status: Publishe
