22 research outputs found
Extracellular copper ions regulate cellular prion protein (PrPC) expression and metabolism in neuronal cells.
No full text[ARTICOLO
Substantial overview on mesenchymal stem cell biological and physical properties as an opportunity in translational medicine
No full textMesenchymal stem cells (MSC) have piqued worldwide interest for their extensive potential to treat a large array of clinical indications, their unique and controversial immunogenic and immune modulatory properties allowing ample discussions and debates for their possible applications. Emerging data demonstrating that the interaction of biomaterials and physical cues with MSC can guide their differentiation into specific cell lineages also provide new interesting insights for further MSC manipulation in different clinical applications. Moreover, recent discoveries of some regulatory molecules and signaling pathways in MSC niche that may regulate cell fate to distinct lineage herald breakthroughs in regenerative medicine. Although the advancement and success in the MSC field had led to an enormous increase in the amount of ongoing clinical trials, we still lack defined clinical therapeutic protocols. This review will explore the exciting opportunities offered by human and animal MSC, describing relevant biological properties of these cells in the light of the novel emerging evidence mentioned above while addressing the limitations and challenges MSC are still facing
Impact of solder-joint tilting on the reliability of LED-based PCB assemblies: A combined experimental and FEM analysis
No full textThe impact of solder-joint tilting on the reliability of high-power LEDs soldered on PCBs is investigated by means of FEM simulations correlated with thermal cycling experiments. A non-uniform solder joint stand-off height is implemented into the FEM and, using crack propagation modelling approach, the number of cycles to complete fracture are predicted. © 2015 IEEE
STRUMENTO PER IL MONITORAGGIO IN TEMPO REALE DELLO SCAVO LOCALIZZATO ATTORNO ALLE PILE DI PONTE
No full textDose Enhancement Due to Interconnects in Deep-Submicron MOSFETs Exposed to X-Rays
No full textWe present the first experimental report of dose-enhancement
effects due to interconnects in deep-submicron CMOS,
using ad hoc designed MOSFETs with different metal layouts.We
demonstrate that the presence of metal-1 tracks in the proximity
of the device active areas may significantly modify the response
to X-rays. The impact of the secondary electron emission from
metal-1 layers is strongly dependent on the relative position to the
transistor lateral isolation and LDD spacers
Indagini batteriologiche sulle infezioni dell’apparato genitale femminile. Nota 1:Prevalenza di Neisseria gonorrhoeae, Chlamydia trachomatis, micoplasmi, streptococco di guppo B e Listeria monocytogenes.
No full textEffect of postmortem interval on the Graft Endothelium During Preservation and After Transplantation for Keratoconus.
No full textPURPOSE: To investigate the effect of postmortem intervals and prognostic factors on endothelial cell density (ECD) of human donor corneas during preservation and at 1 and 3 years after transplantation in patients transplanted for keratoconus.
METHODS: Two different studies were performed: (1) with 733 donor corneas selected for the preservation study and (2) 64 patients with keratoconus selected retrospectively from 2 hospital clinics. The corneas were evaluated on the basis of the ECD during preservation, study A, and at 1 and 3 years after transplantation, study B. The effect of ≥10 hours of postmortem interval on the percentage of corneal endothelial cell loss (ECL) was determined.
RESULTS: The multiple regression showed no statistical significance (P = 0.827) of postmortem interval on ECL during preservation. However, for patients with keratoconus, the postmortem interval was statistically significant at both 1 year (P < 0.0001) and 3 years after transplantation (P < 0.0001).
CONCLUSIONS: The postmortem interval has no influence on the ECD during preservation. However, it has a statistically significant effect on the ECL after transplantation for patients transplanted for keratoconus, and therefore, it becomes eligible to be one of the potential factors affecting the ECD apart from surgical trauma
Dose Enhancement due to Interconnects in Deep-Submicron MOSFETs Exposed to X-Rays
No full textWe present the first experimental report of dose-enhancement effects due to interconnects in deep-submicron CMOS, using ad-hoc designed MOSFETs with different metal layouts. We demonstrate that the presence of metal-1 tracks in the proximity of the device active areas may significantly modify the response to X-rays. The impact of the secondary electron emission from metal-1 layers is strongly dependent on the relative position to the transistor lateral isolation and LDD spacers
Behavior of B- and Z-DNA Crystals under High Hydrostatic Pressure
No full textCERVOXYInternational audienceSingle crystals of B-DNA and Z-DNA oligomers were analyzed under high hydrostatic pressure and their behavior compared to the A-DNA crystals already known. The amplitude of the base compression, when compared to the A-form of DNA (0.13 Å/GPa), was higher for the Z DNA (0.32 Å/GPa) and was the highest for the B-DNA (0.42 Å/GPa). The B-DNA crystal degraded rapidly around 400-500 MPa while the Z-structure was more resistant, up to 1.2 GPa
