66 research outputs found
La ciclina D1 come nuovo indicatore predittivo nel carcinoma mammario del cane: studi preliminari
No full textMessa a punto di modelli animali per la sperimentazione di malattie antinoplastiche innovative: il tumore mammario canino. , vol.
No full textMessa a punto di modelli animali per la sperimentazione di malattie antinoplastiche innovative: il tumore mammario canino. , vol.
No full textFludarabine delivery by autologous red blood cells induces macrophage depletion in chronically SIV-infected Sooty Mangabeys.
No full textEspressione della Ciclina D1 nelle lesioni mammarie pre-neoplastiche e neoplastiche della cagna.
No full textEspressione della Ciclina D1 nelle lesioni mammarie pre-neoplastiche e neoplastiche della cagna.
No full textValutazione dell’attività antiproliferativa di succo di Brassica oleracea in cellule di tumore mammario umano
No full textMechanisms of action and antiproliferative properties of Brassica oleracea juice in human breast cancer cell lines
No full textCruciferous vegetables are an important source of compounds that may be useful for chemoprevention.
In this study, we evaluated the antiproliferative activity of juice obtained from leaves of several varieties of
Brassica oleracea on both estrogen receptor (ER)-positive (ER; MCF-7 and BT474) and ER-negative (ER;
MDA-MB-231 and BT20) human breast cancer cell lines. The effect of juice on cell proliferation was evaluated on
DNA synthesis and on cell cycle–related proteins. Juice markedly reduced DNA synthesis, evaluated by [3H]thymidine
incorporation, starting from low concentrations (final concentration 5–15 mL/L), and this activity was
independent of ER. All cauliflower varieties tested suppressed cell proliferation in a dose-dependent manner. Cell
growth inhibition was accompanied by significant cell death at the higher juice concentrations, although no
evidence of apoptosis was found. Interestingly, the juice displayed a preferential activity against breast cancer cells
compared with other mammalian cell lines investigated (ECV304, VERO, Hep2, 3T3, and MCF-10A) (P 0.01). At
the molecular level, the inhibition of proliferation was associated with significantly reduced CDK6 expression and
an increased level of p27 in ER cells but not in ER cells, whereas a common feature in all cell lines was
significantly decreased retinoblastoma protein phosphorylation. These results suggest that the edible part of
Brassica oleracea contains substances that can markedly inhibit the growth of both ER and ER human breast
cancer cells, although through different mechanisms. These results suggest that the widely available cruciferous
vegetables are potential chemopreventive agents.
A new indole-3- carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-indipendent breast cancer cell lines.
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