1,085 research outputs found
Data and code for: Specializations in optic flow encoding in the pretectum of hummingbirds and zebra finches
No full textData and code for: "Specializations in optic flow encoding in the pretectum of hummingbirds and zebra finches" by Smyth G, Baliga VB, Gaede AH, Wylie DR, and Altshuler DLAny questions about this repository can be directed to: Vikram B. Baliga ([email protected])</div
Apaf-1/cytochrome c apoptosome: an essential initiator of caspase activation or just a sideshow?
No full textCopyright © 2003 Nature Publishing GroupB Baliga and S Kuma
Data and code for: Hummingbirds use distinct control strategies for forward and hovering flight
No full textData and code for: "Hummingbirds use distinct control strategies for forward and hovering flight" by Baliga VB, Dakin R, Wylie DR, and Altshuler DL; Proceedings of the Royal Society B: Biological SciencesQuestions/concerns/comments: Vikram Baliga ([email protected])Data:- All data required to re-create analyses and figures are stored within /processed_data_exports. Note that these are not original (Flydra) data; due to file size constraints, Flydra data cannot be included here.- The /lookup_and_metadata directory contains several files that describe the metadata and other important characteristics of the original data and subjectsCode:- All code required to re-create analyses and figures are provided as .R files.- The two "master_script_" files are required to be run prior to recreating figures. Objects that figure creation relies on are generated by the master scripts- Files to support the master scripts are house in /data_import_scripts, but do not need to be called directly by the user. Rather, the master scripts will source these auxiliary files automatically as needed.- Code for each figure is provided within separate .R files. Multi-panel plots are created wherever possible, but might differ slightly in presentation from their final format due to rendering differences across platforms.</p
Community health and prevention: It takes a village to reduce cardiovascular risk! Let us do it together!
No full textUtilização do load flow no planejamento de sistemas de potência a médio prazo
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica
Automated detection and containment of stealth attacks on the operating system kernel
No full textThe operating system kernel serves as the root of trust for all applications running on the computer system. A compromised system can be exploited by remote attackers stealthily, such as exfiltration of sensitive information, wasteful usage of the system's resources, or involving the system in malicious activities without the user's knowledge or permission. The lack of appropriate detection tools allows such systems to stealthily lie within the attackers realm for indefinite periods of time. Stealth attacks on the kernel are carried out by malware commonly known as rootkits. The goal of the rootkit is to conceal the presence of the attacker on the victim system. Conventionally, kernel rootkits modified the kernel to achieve stealth, while most functionality was provided by accompanying user space programs. The newer kernel rootkits achieve the malice and stealth solely by modifying kernel data. This dissertation explores the threat posed by both types of kernel rootkits and proposes novel automated techniques for their detection and containment. Our first contribution is an automated containment technique built using the virtualization architecture. This technique counters the ongoing damage done to the system by the conventional kernel rootkits. It is well suited for attacks that employ kernel or user mode stealth but provide most of the malicious functionality as user space programs. Our second contribution is to identify a new class of stealth attacks on the kernel, which do not exhibit explicit hiding behavior but are stealthy by design. They achieve their malicious objectives by solely modifying data within the kernel. These attacks demonstrate that the threat posed to kernel data is systemic requiring comprehensive protection.
Our final contribution is a novel automated technique that can be used for detection of such stealth data-centric attacks. The key idea behind this technique is to automatically identify and extract invariants exhibited by kernel data structures during a training phase. These invariants are used as specifications of data structure integrity and are enforced during runtime. Our technique could successfully detect all rootkits that were publicly available. It could also detect more recent stealth attacks developed by us or proposed by
other recent research literature.Ph.D.Includes bibliographical references (p. 99-103)by Arati Balig
Fig. 1. Baliga kashmirensissp. nov. Dorsal habitus. A in Taxonomic notes on the antlion tribe Myrmeleontini Latreille (Neuroptera, Myrmeleontidae, Myrmeleontinae) from Pakistan, with description of a new species
No full textFig. 1. Baliga kashmirensissp. nov. Dorsal habitus. A. Male (CAUPK00001).B. Female (CAUPK00002). Scale bars = 5.0 mm.Published as part of Hassan, Muhammad Asghar, Zheng, Yuchen & Liu, Xingyue, 2022, Taxonomic notes on the antlion tribe Myrmeleontini Latreille (Neuroptera, Myrmeleontidae, Myrmeleontinae) from Pakistan, with description of a new species, pp. 1-44 in European Journal of Taxonomy 831 on page 7, DOI: 10.5852/ejt.2022.831.1867, http://zenodo.org/record/686220
Role of BCL-2 family of proteins in malignancy
No full textCopyright © 2008 John Wiley & Sons, Ltd.B cell lymphoma gene-2 (Bcl-2) is the prototypic member of a growing family of proteins that play evolutionarily conserved, key regulatory roles in apoptosis. The Bcl-2 family members are characterized by the presence of one or more Bcl-2 homology domains and are comprised of both the prosurvival and proapoptotic proteins. Bcl-2 itself is a prosurvival member of the family and its aberrant expression has been linked to a variety of different cancers, including several hematological malignancies. Although the exact mechanism of action of Bcl-2 family of proteins in regulating apoptosis is still a matter of some debate, these proteins appear to act upstream of caspase activation. Many recent studies have shown the therapeutic potential of targeting Bcl-2 family members for the treatment of cancer. This article summarizes what is currently known about Bcl-2-like proteins and how the evolving understanding of the biology of these proteins is paving way for the development of novel cancer therapeutics.Belinda C. Baliga, Sharad Kuma
The biochemical mechanism of caspase-2 activation
No full textCopyright © 2004 Nature Publishing GroupA unified model for initiator caspase activation has previously been proposed based on the biochemical analysis of caspase-8 and -9. Caspase-2 is structurally related to caspase-9, but its mechanism of activation is not known. Using an uncleavable mutant of caspase-2, we show that dimerization (and not processing) is the key event that drives initial procaspase-2 activation. Following dimerization, caspase-2 undergoes autocatalytic cleavage that promotes its stable dimerization and further enhances the catalytic activity of caspase-2. Although the caspase-2 zymogen does not require cleavage for the initial acquisition of activity, intersubunit cleavage is required to generate levels of activity required to induce cell death by overexpression. We also provide evidence that the reported disulfide bond linkage between two caspase-2 monomers is dispensable for caspase-2 dimerization. As caspase-2 does not require cleavage for its initial activation, our findings confirm caspase-2 to be a bona fide initiator caspase.B C Baliga, S H Read and S Kuma
Thermal modeling of polymerizing polymethylmethacrylate, considering temperature-dependent heat generation
No full textA methodology for the modeling of unsteady heat conduction in polymethylmethacrylate (PMMA) during its exothermic polymerization is presented. The emphasis is on the formulation of a model for the volumetric rate of heat generation, including its temperature-dependent characteristics. Three parameters appear in the proposed model. The empirical determination of these parameters using Differential Scanning Calorimetry is demonstrated. The incorporation of the proposed model into finite volume methods is also demonstrated, in the context of unsteady, one-dimensional, radial heat conduction in cylindrical coordinates. In addition, the application of the proposed model to two test problems is presented and discussed. The results are encouraging, and the proposed methodology appears to be applicable to the thermal modeling of exothermic polymerization processes in general.LR: 20061115; PUBM: Print; JID: 7909584; 0 (Bone Cements); 0 (Methylmethacrylates); ppublishSource type: Electronic(1
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