68,325 research outputs found
George B. Cox portrait
No full textGeorge B. Cox (1853-1916) of Cincinnati was a delegate to the 1900 Republican National Convention from Ohio. He was indicted on corruption charges in 1906, but was never convicted. He served as a Cincinnati City Councilman in 1879, but continued to influence politics through money, gifts, and illegal voting practices
Cox, Herald -- 1954-64 -- Correspondence, Individual -- letter, 1954-08-03
No full textLetter from Cox, Herald R. to Sabin, Albert B. dated 1954-08-03.Sabin Collection Fair Use Policy</a
Cox, Herald -- 1954-64 -- Correspondence, Individual -- letter, 1964-07-23
No full textLetter from Cox, Herald R. to Sabin, Albert B. dated 1964-07-23.Sabin Collection Fair Use Policy</a
Cox, Herald -- 1954-64 -- Correspondence, Individual -- letter, 1954-10-06
No full textLetter from Sabin, Albert B. to Cox, Herald dated 1954-10-06.Sabin Collection Fair Use Policy</a
Cox, Herald -- 1954-64 -- Correspondence, Individual -- letter, 1954-08-07
No full textLetter from Sabin, Albert B. to Cox, Herald dated 1954-08-07.Sabin Collection Fair Use Policy</a
Selective COX-2 inhibitors and risk of myocardial infarction
No full textSelective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel
Cox-assay description.
No full text(A) Table describes the compounds tested in the cox-1 inhibitor assay, their source and usage. Triflusal is the drug which is known to bind to Cox-1 and it was a positive control in our experiment. The food compound which came out as hit with our prediction models is 5-methoxysalicylic acid (referred to as test compound) for which target engagement is being studied. Additional inclusion was 4-isopropylbenzoic acid (selected based on high FM score as compared to test compound but deemed no match by prediction models) as a negative control. (B) The reaction mechanism involves fluorometric detection of intermediate product (prostaglandin G2) generated by cox-enzyme. (TIFF)</p
Interview with Mark Cox
No full textMark Cox is a professor of Creative Writing at UNCW, and has served as Chair of the department. He is the author of three full-length poetry collections: Smoulder, Thirty-Seven Years from the Stone, and Natural Causes
On Campus Video, featuring Abilene (TX) businessman and author Jack Cox.
No full textA videorecording of an interview with Abilene (TX) businessman and author Jack Cox, conducted by Dr. Gary McCaleb of Abilene Christian University
Concentration in Knowledge Output: A case of Economics Journals
No full textThis paper assesses the degree of author concentration in seven economics journals, which were published in India during 1990-2002. To measure the degree of author concentration, Lotka's Law was used. Moreover, we also make an exploratory analysis of the geographic, economics subfield and institutional concentration in 704 economics journals. An important finding of this paper is that specialized journals in the sample report the highest degree of author concentration. This result is quite similar to the findings by Cox and Chung (1991). Furthermore, there are several instances showing that the journals lean towards certain norms; this may affect the flow of innovative ideas into economics. We conclude that a knowledge activity, involving the high degree of concentration and a biased publication process, may affect the flow of new ideas into the discipline.Concentration, Lotka's Law
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