180 research outputs found
Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells
No full text博士論文本文Full 以下に掲載：Oncotarget 5(13) pp.4920-1928 2014. Creative Commons. 共著者：Azusa Tanimoto, Tadaaki Yamada, Shigeki Nanjo, Shinji Takeuchi, Hiromichi Ebi, Kenji Kita, Kunio Matsumoto, Seiji Yan
Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells
No full text金沢大学博士（医学）博士論文本文Full 以下に掲載：Oncotarget 5(13) pp.4920-1928 2014. Creative Commons. 共著者：Azusa Tanimoto, Tadaaki Yamada, Shigeki Nanjo, Shinji Takeuchi, Hiromichi Ebi, Kenji Kita, Kunio Matsumoto, Seiji Yanodoctoral thesi
Letter from Morio Tanimoto to Mr. and Mrs. Okine, January [1], [1948?] [in Japanese]
No full textA New Year's letter from Morio Tanimoto to Seiichi and Tomeyo Okine. Morio Tanimoto is a father of their daughter-in-law, Ayame Okine. He expresses his appreciation for the Christmas gift from the Okines, and is glad to see a photograph of Ayame's daughter, Jeanne Okine.The Okine Collection contains materials collected by Seiichi and Tomeyo Okine who were Issei flower growers in Whittier, California. It includes correspondence, photographs, financial documents, and a photo album. A large portion of the collection consists of family correspondence with Seiichi and Tomeyo Okine, including letters from their Nisei children, Masao and Makoto Okine, both soldiers overseas during World War II, to their Issei parents incarcerated in the Rohwer incarceration camp in McGehee, Arkansas. The correspondence also includes letters from their relatives and friends who are former incarcerees in the camps during the war and have “resettled” in Chicago, Illinois as well as letters from the Okines’ family members in Hiroshima, Japan during the Allied occupation of Japan. In addition, the collection includes a family photo album compiled by Dorothy Ai Aoki, a Nisei daughter to the Okines
Letter from Morio Tanimoto to Seiichi Okine, January 16, 1946 [in Japanese]
No full textA letter from Morio Tanimoto in Lodi, California, to Seiichi Okine in Hawthorne, California. He thanks Seiichi for his gift and also congratulates on his daughter, Hatsuno's marriage, enclosing the monetary gift for her. This letter is sent by Akiko Tanimoto and addresses Dorothy Okine. The handwritten notes on the back of the envelope read: Arrived on January 19 [in Japanese].The Okine Collection contains materials collected by Seiichi and Tomeyo Okine who were Issei flower growers in Whittier, California. It includes correspondence, photographs, financial documents, and a photo album. A large portion of the collection consists of family correspondence with Seiichi and Tomeyo Okine, including letters from their Nisei children, Masao and Makoto Okine, both soldiers overseas during World War II, to their Issei parents incarcerated in the Rohwer incarceration camp in McGehee, Arkansas. The correspondence also includes letters from their relatives and friends who are former incarcerees in the camps during the war and have “resettled” in Chicago, Illinois as well as letters from the Okines’ family members in Hiroshima, Japan during the Allied occupation of Japan. In addition, the collection includes a family photo album compiled by Dorothy Ai Aoki, a Nisei daughter to the Okines
Abstract 4681: Histone deacetylase 3 inhibition overcomes <i>BIM</i> deletion polymorphism-mediated osimertinib resistance in <i>EGFR</i>-mutant lung cancer
No full textAbstract
Purpose:The BIM deletion polymorphism is associated with apoptosis resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, in non-small cell lung cancer (NSCLC) harboring EGFR mutations. Here, we investigated whether the BIM deletion polymorphism contributes to resistance against osimertinib, a third-generation EGFR-TKI. In addition, we determined the efficacy of a histone deacetylase (HDAC) inhibitor, vorinostat, against this form of resistance and elucidated the underlying mechanism.
Experimental Design:We used EGFR-mutated NSCLC cell lines which were either heterozygous or homozygous for the BIM deletion polymorphism to evaluate the effect of osimertinib in vitro and in vivo. Protein expression was examined by western blotting. Alternative splicing of BIM mRNA was analyzed by RT-PCR.
Results:EGFR-mutated NSCLC cell lines with the BIM deletion polymorphism exhibited apoptosis resistance to osimertinib in a polymorphism dosage-dependent manner, and this resistance was overcome by combined use with vorinostat. Experiments with homozygous BIM deletion-positive cells revealed that vorinostat affected the alternative splicing of BIM mRNA in the deletion allele, increased the expression of active BIM protein, and thereby induced apoptosis in osimertinib-treated cells. These effects were mediated predominantly by HDAC3 inhibition. In xenograft models, combined use of vorinostat with osimertinib could regress tumors in EGFR-mutated NSCLC cells homozygous for the BIM deletion polymorphism. Moreover, this combination could induce apoptosis even when tumor cells acquired EGFR-T790M mutations.
Conclusions:These findings indicate the importance of developing HDAC3-selective inhibitors, and their combined use with osimertinib, for treating EGFR-mutated lung cancers carrying the BIM deletion polymorphism.
Note: This abstract was not presented at the meeting.
Citation Format: Azusa Tanimoto. Histone deacetylase 3 inhibition overcomes BIM deletion polymorphism-mediated osimertinib resistance in EGFR-mutant lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4681. doi:10.1158/1538-7445.AM2017-4681</jats:p
Letter from Morio Tanimoto to Mr. and Mrs. S. Okine, October 30, 1947 [in Japanese]
No full textA letter from Morio Tanimoto to his daughter's parents-in-law, Seiichi and Tomeyo Okine. He thanks the Okines for the gift pertaining to the birth and giving a name, "Masaye." Jeanne Masaye Okine is their newly born granddaughter.The Okine Collection contains materials collected by Seiichi and Tomeyo Okine who were Issei flower growers in Whittier, California. It includes correspondence, photographs, financial documents, and a photo album. A large portion of the collection consists of family correspondence with Seiichi and Tomeyo Okine, including letters from their Nisei children, Masao and Makoto Okine, both soldiers overseas during World War II, to their Issei parents incarcerated in the Rohwer incarceration camp in McGehee, Arkansas. The correspondence also includes letters from their relatives and friends who are former incarcerees in the camps during the war and have “resettled” in Chicago, Illinois as well as letters from the Okines’ family members in Hiroshima, Japan during the Allied occupation of Japan. In addition, the collection includes a family photo album compiled by Dorothy Ai Aoki, a Nisei daughter to the Okines
Letter from Kimiye Tanimoto to Mr. and Mrs. S. Okine, October 2, 1947 [in Japanese]
No full textA letter from Kimiye Tanimoto to her relatives, Seiichi and Tomeyo Okine. Kimiye is a sister-in-law of the Okine's son, Masao Okine. She recently returned from Japan to the US and is producing grapes in Lodi, California. In the letter, she gives appreciation to Seiichi and Tomeyo for their visit and gifts.The Okine Collection contains materials collected by Seiichi and Tomeyo Okine who were Issei flower growers in Whittier, California. It includes correspondence, photographs, financial documents, and a photo album. A large portion of the collection consists of family correspondence with Seiichi and Tomeyo Okine, including letters from their Nisei children, Masao and Makoto Okine, both soldiers overseas during World War II, to their Issei parents incarcerated in the Rohwer incarceration camp in McGehee, Arkansas. The correspondence also includes letters from their relatives and friends who are former incarcerees in the camps during the war and have “resettled” in Chicago, Illinois as well as letters from the Okines’ family members in Hiroshima, Japan during the Allied occupation of Japan. In addition, the collection includes a family photo album compiled by Dorothy Ai Aoki, a Nisei daughter to the Okines
Conformal Covariance and the Split Property
No full textWe show that for a conformal local net of observables on the circle, the split property is automatic. Both full conformal covariance (i.e., diffeomorphism covariance) and the circle-setting play essential roles in this fact, while by previously constructed examples it was already known that even on the circle, Möbius covariance does not imply the split property. On the other hand, here we also provide an example of a local conformal net living on the 2-dimensional Minkowski space, which—although being diffeomorphism covariant—does not have the split property. © 2017 The Author(s
Sorafenib treatment for patients with RET fusion-positive non-small cell lung cancer
No full text主査 : 伊豫田明 / タイトル : Sorafenib treatment for patients with RET fusion-positive non-small cell lung cancer / 著者 : Atsushi Horiike, Kengo Takeuchi, Takeshi Uenami, Yuko Kawano, Azusa Tanimoto, Kyohei Kaburaki, Yuichi Tambo, Keita Kudo, Noriko Yanagitani, Fumiyoshi Ohyanagi, Noriko Motoi, Yuichi Ishikawa, Takeshi Horai, Makoto Nishio/ 掲載誌 : Lung Cancer /巻号・発行年等 : 93:43-46, 2016 / 本文ファイル: 出版者
Letter from Morio Tanimoto to Seiichi Okine, February 18, [1945-1947] [in Japanese]
No full textA letter from Morio Tanimoto to his relatives, Seiichi and Tomeyo Okine. Morio is a father of their daughter-in-law, Ayame Okine. In the letter, he thanks them for the oranges and tangerines. He includes updates on his crops: that he is finished pruning and is starting to plant seeds for grapes.The Okine Collection contains materials collected by Seiichi and Tomeyo Okine who were Issei flower growers in Whittier, California. It includes correspondence, photographs, financial documents, and a photo album. A large portion of the collection consists of family correspondence with Seiichi and Tomeyo Okine, including letters from their Nisei children, Masao and Makoto Okine, both soldiers overseas during World War II, to their Issei parents incarcerated in the Rohwer incarceration camp in McGehee, Arkansas. The correspondence also includes letters from their relatives and friends who are former incarcerees in the camps during the war and have “resettled” in Chicago, Illinois as well as letters from the Okines’ family members in Hiroshima, Japan during the Allied occupation of Japan. In addition, the collection includes a family photo album compiled by Dorothy Ai Aoki, a Nisei daughter to the Okines
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