57 research outputs found
Strategic Planning of Information System in PT Satya Mitra Sejahtera Using Ward and Peppard
No full textIncreasing demand in every company for information systems strategic planning in order to increase efficiency, effectiveness and increase competitive advantage programmatically with a priority scale, given the information system resources and other supporting devices are still limited, so the existence of an information system strategic plan will help the company. One of them is PT Satya Mitra Sejahtera, which is engaged in business, which is currently not fully using information systems to its full potential. The quality of information systems becomes the most important component because it requires an analysis of the strategic planning of information systems to determine whether the information system that was developed can be used properly. In this study, the author will conduct an information system strategic planning using the Ward and Peppard method. This method was chosen because it can evaluate business conditions and information systems that occur at this time, by looking at the business environment and information system environment externally and internally. The Ward and Peppard method have several stages, the first stage of analyzing the internal and external business environment using the PEST and value chain. Analysis of the internal and external environment of information systems using SWOT, while the application portfolio mapping uses Mc Farlan Strategic Grid. The results of strategic design research using Ward and Peppard methods can produce maps of internal and external conditions of the organization, so that can find out the strengths, weaknesses, opportunities, and threats owned by PT. Satya Mitra Sejahtera
Correction: The long and short non-coding RNAs modulating EZH2 signaling in cancer (Journal of Hematology & Oncology, (2022), 15, 1, (18), 10.1186/s13045-022-01235-1)
No full textThe original article 1 contained an error in co-author, Farid Hashemi�s name which has since been corrected. © 2022, The Author(s)
Proteins expression clustering of Alzheimer disease in rat hippocampus proteome
No full textBecause of the huge amounts of proteomic data and demand for new methods of laboratory analysis results, proteins collective analysis, in addition to taking less time, biostatistician assist at identification of new patterns in the data set. In this study, rat hippocampus proteome in normal and Alzheimer's disease (AD) were analyzed by using proteomic techniques and bioinformatics’ analysis. Protein extracts from normal and Alzheimer's rats were separated by using two-dimensional electrophoresis (2DE). The silver staining method was used for detecting spots. Bioinformatics analysis of proteome were performed by progensis same spots software. Bioinformatics and statistical analysis of 2DE gel techniques obtained 760 protein spots were detected in both normal and AD rats. Comparisons between controls and Alzheimer gel containing 20 common proteins were expressed significantly differences. 16 new proteins were expressed in AD, while 36 proteins were suppressed. Proteins clustering by using correlation analysis evaluated 3 clusters in the proteome; Principal component analysis also confirmed the results of clustering. Finally, we can conclude that a significant expression of Alzheimer changes in the hippocampus proteome which are associated with specific biological processes summarized in 3 main clusters indicated 3 principal biological pathways of AD.
Ali ibn Hosein Ansari (1330–1404): a Persian pharmacist and his pharmacopoeia, <i>Ekhtiyarat i Badi i</i>
No full text Ekhtiyarat i Badi i ( Badi i Selections) is a drug manual of traditional Persian medicine, well known in Farsi-speaking countries, the Middle East and India. The author was the greatest pharmacist-physician of the 13th-century Mongolian period in Persia. The unique style of writing, with authoritative and critical drug overviews, made his book an invaluable Farsi reference of traditional pharmacy for four centuries. In spite of adverse social and political circumstances in the Mongolian era, the book contributed to the reconstitution of Persian pharmacy and medicine, serving as a basic reference for the compilation of other drug manuals and scientific works for centuries after its introduction. </jats:p
Complexity on modulation of NF‐κB pathways by hepatitis B and C: A double‐edged sword in hepatocarcinogenesis
No full textComplexity on modulation of NF-κB pathways by hepatitis B and C: A double-edged sword in hepatocarcinogenesis
No full textNuclear factor-κB (NF-κB), a family of master regulated dimeric transcription factors, signaling transduction pathways are active players in the cell signaling that control vital cellular processes, including cell growth, proliferation, differentiation, apoptosis, morphogenesis, angiogenesis, and immune responses. Nevertheless, aberrant regulation of the NF-κB signaling pathways has been associated with a significant number of human cancers. In fact, NF-κB acts as a double-edged sword in the vital cellular processes and carcinogenesis. This review provides an overview on the modulation of the NF-κB signaling pathways by proteins of hepatitis B and C viruses. One of the major NF-κB events that are modulated by these viruses is the induction of hepatocellular carcinoma. Given the central function of NF-κB in carcinogenesis, it has turned out to be a considerable therapeutic target for cancer therapy
Antibacterial effects of Scrophularia striata seed aqueous extract on staphilococcus aureus
No full textPlant-based drugs are regarded promising recently. Scrophularia has been shown various biological activities such as antimicrobial, antitumor and anti-inflammatory properties. According to pervious researches, bacteria are becoming resistant to some kinds of antibiotics, so it is prominent to find more reliable sources against them. Here Staphylococcus aureus as a common type of Gram- positive bacteria has been chosen for this in vitro study. After culturing this bacterium, it was treated with various dosages of Scrophularia striata seed aqueous extract and tetracycline, and then its antibacterial effect was assessed by spectrophotometery method based on bacteria population alteration after 24h incubation. In order to investigate probable side effects of the seed extract its effect on human fibroblast cells has been studied. MTT assay was applied for cell survival determination of human fibroblast cells after 24h. Findings indicate that bacterial population has been declined between 1 to 20 μg mL-1 dosages of the extract, which 5 μg mL-1 is the most effective dosage without containing any cytotoxic effect on human fibroblast cells. In fact extract not only has no antiproliferation properties but also has evoked cell profileration, so it can be consider as a cell growth factor. Tetracycline, on the contrary, showed its potent impact merely in highest dosages with noticeable side effects. It can be concluded that, Scrophularia striata could be possibly a promising antibiotic which shows significant antibacterial properties, and with lesser side effects.
The association between leisure-time physical activity and blood pressure changes from adolescence to young adulthood: Tehran Lipid and Glucose Study
No full textAbstract The effectiveness of long-term leisure time physical activity (LTPA) on blood pressure (BP) changes is still under debate. Since adolescence lifestyle behaviors shape the adulthood health profile, this study aimed to investigate the sex-specific impact of LTPA on BP changes from adolescence to young adulthood. This longitudinal study uses the data of 1412 adolescents (52% females) aged 12–18 years through a median follow-up of 12.2 years in the Tehran Lipid and Glucose Study (TLGS) framework. LTPA was calculated using the reliable and valid Iranian version of the modified activity scale (MAQ), and BP was measured at least twice by trained physicians. The linear mixed model was used to examine the study variables, considering individual and intrapersonal differences during the study. The majority of participants consistently demonstrated insufficient LTPA throughout the follow-up assessments, ranging from 54.7 to 67.1% for males and 77.7–83.4% for females. Despite a declining trend in LTPA (β = − 2.77 for males and β = − 1.43 for females), an increasing trend was noticeable in SBP, DBP, and BMI (β = 1.38, β = 1.81, β = 0.97 for males, and β = 0.10, β = 0.20, β = 0.97 for females, respectively). The unadjusted model revealed a significant trend in all variables for both sexes, except for female BP (P = 0.45 for SBP and P = 0.83 for DBP). Using the adjusted model, no significant association was observed between LTPA and changes in BP over time in both sexes. Our study indicates no association between LTPA and BP changes from adolescence to young adulthood. Insufficient LTPA levels, particularly among Iranian females, are likely the primary factor. Further research is crucial to identify appropriate LTPA levels to promote cardiovascular health and implement targeted interventions to achieve optimal LTPA levels in the Iranian population
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