323,842 research outputs found
A Facility Location-Allocation Model for Determining Number of Depot to Distribute Material in the Rattan Furniture Industry by Considering Dynamic Demand
Get PDFThis paper is a study of a facility location-allocation problem in the rattan furniture industry. There
are six production centers (PCs) of rattan furniture in Surakarta and its surroundings. However, their export
sales are decline due to some possible problems in raw rattan distribution network from the sources centers
(SCs), e.g. Borneo and Celebes Island to production centers. In the previous research, the model was expanded
to support local government decide to determine optimal number of depot by consider static demand. This
policy is aimed to cut the distribution channel and reduce total supply chain costs. Due to changing of global
market, the demand is fluctuate. The previous model cannot anticipate this situation; consequently the local
government needs a facility location-allocation model by considering dynamic demand. The objective of this
research is to develop a model for supporting the local government to decide optimal number of depot by
considers dynamic demand. A mixed integer non-linear programming (MINLP) was proposed to minimize total
supply chain costs. The proposed model assumed that the demand for multiple products is known in advance.
The potential raw rattan depot and source locations as well as their maximum capacities are also known.
Finally, the proposed model can be used as instrument decision making to determine facility location-allocation.
Keywords: dynamic demand, a facility location-allocation model, rattan industry competitiveness, total supply
chain costs
GAYA KOMUNIKASI DAKWAH USTAZAH LIZA AZIZAH PADA CHANNEL ILHAM TV
Get PDFABSTRAK
Skripsi dengan judul “Gaya Komunikasi Dakwah Ustazah Liza Azizah pada
Channel Ilham TV” ini ditulis oleh Muhamad Khoirudin, NIM. 126311211017,
dengan pembimbing Dr. Bobby Rachman S, M.S.I. dan Dr. Samsul Rifa’I, M.Pd, I.
Kata kunci: Dakwah, Gaya Komunikasi, Channel Ilham TV
Dakwah Islam di era teknologi modern mengalami kemajuan besar,
terutama melalui media sosial seperti Youtube, di mana peran para dai, termasuk
Ustazah Liza Azizah menjadi suatu hal penting dalam menyebarkan ajaran Islam
dengan cara yang unik, menarik dan relevan bagi masyarakat luas. Penelitian ini
menyoroti pentingnya peningkatan keilmuan, komunikasi, dan implikasi dakwah
bagi para dai di media sosial.
Tujuan dari penelitian ini adalah: 1) Mengetahui gaya komunikasi Ustazah
Liza Azizah pada Channel Ilham TV. 2) Mengetahui implikasi dakwah Ustazah Liza
Azizah dalam membina spiritual masyarakat pada Channel Ilham TV. Jenis
penelitian ini adalah penelitian kualitatif yang spesifikasinya yaitu penelitian
fenomenologis. Adapun pendekatan yang digunakan dalam penelitian ini adalah
dengan menggunakan pendekatan psikologis, pengumpulan data menggunakan
teknik observasi non-partisipan, wawancara dan dokumentasi, analisis data
menggunakan teori Miles dan Huberman. Hasil dari penelitian ini adalah: 1)
komunikasi dakwah Ustazah Liza Azizah dapat dianalisis kepada 3 bentuk uraian,
yaitu melalui seni suara, tren fashion dan bahasa kultural, maka terbentuklah bentuk
gaya komunikasi dari Ustazah Liza Azizah dalam berdakwah yaitu The dynamic
style, The equalitarian style, dramatic, Animated expresive, open dan impression
leaving. Di setiap gaya tersebut dapat menarik masyarakat Indonesia untuk
merespon dakwahnya. 2) Dakwah Ustazah Liza Azizah melalui Channel Ilham TV
memiliki implikasi yang signifikan dalam hal membina spiritual masyarakat,
menjaga solidaritas ukhuwah insaniyah, perihal menghibur masyarakat dan banyak
mencuri perhatian melalui keteladanan paras menawannya. Dakwah Ustazah Liza
Azizah pada Channel Ilham TV banyak mendapatkan respon positif dari para
netizen, mereka berharap bahwa Ustazah Liza dapat menjadi dai muslimah yang
dapat membimbing ke jalan yang benar di tengah-tengah kehidupan masyarakat
Nurul Azizah 10100119060's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Nurul Azizah 10100119060's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Nurul Azizah 10100119060's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dose-response analysis of nanomaterial toxicity
No full textdexamethasone therapy, we apply physiologically-based pharmaco-kinetic (PBPK) modelling to predict foetal exposure after maternal dosing. Methods: To characterize the placental handling of dexametha-sone ex vivo, we performed dual-side perfused isolated human cotyledon experiments (n = 3) with term placenta in closed-closed setting. The tissue was perfused for 3 hours with 70 ng/mL dexamethasone in Krebs-Henseleit buffer. Next, intrinsic unbound placental transfer values were derived from the perfusion data using a physiologically-based semi-mechanistic placenta (PBMP) model in Matlab. Values were used for parameterization of Simcyp's pregnancy-PBPK (p-PBPK) model to predict maternal and foetal exposure. In addition, to evaluate whether placental exposure to the drug may result in adverse effects on placental syncytiotrophoblasts, a toxicity screening exposing BeWo cells to dexamethasone concentrations in a range of 5-25.000 nM for 24 hours was executed. Results: Perfusion experiments showed that dexamethasone extensively crosses the placenta. The PBMP model adequately described the perfusion data. The intrinsic unbound transfer values derived, were estimated to be 1033.5 mL/min and 15.2 mL/min for the maternal placental uptake and efflux, and 1311.1 mL/min and 10.7 mL/ min for foetal placental uptake and efflux, respectively. For an intramuscular dose of 8 mg at 28 weeks of gestation, whole body p-PBPK modelling predicted a C max and AUC 0−∞ of 46.09 ng/mL and 230.46 ng/ml*h in maternal plasma and a C max and AUC 0−∞ of 18.60 ng/mL and 100.25 ng/ml*h in the umbilical vein, respectively. Umbilical vein plasma concentrations derived from literature (range 5.5-23.7 ng/mL) are in accordance with the estimated C max concentration. None of the drug concentrations studied affected placental cell viability or progesterone production in BeWo cells. Conclusion: Ex vivo placenta perfusion in combination with p-PBPK modelling is a relevant approach for foetal exposure predictions. Outcomes can be used in re-evaluation of current dosing regimens of dexamethasone during pregnancy. It is expected that this approach can be used to predict foetal exposure to other pharmaceutical drugs as well, even in absence of umbilical vein concentrations of a drug. As nanomaterials are increasingly used in many different products, it becomes important to know their potential toxicity. In the risk assessment of nanomaterials, in vitro-in vivo extrapolation (IVIVE) techniques are interesting to be explored since they have advantages of maximizing the use of in vitro studies, and reducing the financial and time costs, especially when high numbers of nanomaterials are to be analyzed. The H2020 NanoInformaTIX project is a research project that partly focuses on the study of nanomaterial toxicity, with our goal being, implementing IVIVE methods for use in a strategy for risk assessment of nanomaterials. The initial step of our research includes building a software program (the R package NMTox) to explore the data gathered through the project and to perform preliminary analysis on the dose-response relationship of nanomaterial toxicity. Methods available in this package, such as the Likelihood ratio test, are used to test for the monotonic trend in dose-response relationships, and thus to screen for potential significant dose-response relationships of nanomaterials toxicity, that can be analyzed further. To identify the toxic concentrations, dose-response models are fitted on the subsets of data with a significant trend. The risk assessment strategy will involve applying IVIVE methods described in the literature and will use the estimated in vitro toxic concentration as the basis for the risk calculation. The current stage of our research is focusing on PBPK models to estimate in vivo toxic doses of nanomaterials and to aid the risk assessment strategy. The feasibility of applying this strategy is currently being investigated. We will illustrate this approach using data available in the NanoInformaTIX database and in the literature. Most studies assess the possible adverse effects of exposure to airborne nanomaterials (NMs) using submerged culture systems; however, air-liquid interface (ALI) exposure systems are far better suited for the assessment of in vitro pulmonary effects of NMs as they are more representative of the in vivo respiratory system. Although ALI exposure is preferred over submerged conditions, it is not known how toxicity, uptake and intracellular fate of NMs in cells may be influenced when ALI is compared with submerged exposure conditions. The aim of this study was to compare the distribution, toxicity, and cellular uptake of 14 nm citrate stabilised gold nanoparticles (AuNPs) exposed to human alveolar basal epithelial (A549) cells at the ALI (0.13, 0.21 and 0.443 μg/cm 2), using the VITROCELL ® Cloud 12 in vitro exposure system, to submerged conditions (10, 20, 40 μg/cm 2 , a 10-fold increase to account for sedimentation and diffusion). The toxicity of A549 cells was monitored using the lactate dehydrogenase (LDH) assay as this assay has previously shown to not be affected by interference of AuNPs. The distribution and intracellular uptake were assessed using conventional inverted microscopy and the CytoViva 3D Enhanced Darkfield Imaging System. The AuNPs were shown to be relatively non-toxic under both ALI and submerged conditions, however the cells showed increased sensitivity at the ALI. The distribution and intracellular uptake of the AuNPs were found to be more uniformly distributed, over the exposure area of the transwell insert, at the ALI whereas submerged conditions resulted in agglomerated NPs, outside cells as well as intracellularly. The use of the CytoViva 3D system has shown to be beneficial when assessing uptake of non-labelled NPs within a three-dimensional space. S198 Abstracts / Toxicology Letters 368S1 (2022) S84-S283Supported by European Union’s Horizon 2020 research and innovation programme under grant agreement No 814426 – NanoInformaTIX
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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