330 research outputs found
Raw Data for manuscript published at Nanomaterials, entitled: Asymmetrical Plasmon Distribution in Hybrid AuAg Hollow/Solid Coded Nanotubes
No full text.dm3 TEM, STEM and EELS raw dat
A NEW ANTISEPTIC - FURFURYLAMINE BIGUANIDINE DERIVATIVE SYNTHESIS AND ITS EFFECT ON MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII STRAINS
No full textObjective: The number of antiseptics used in a hospital environment are limited, hence some of them are restricted because of resistance. Furfurylamine biguanidine HCl (FBC) and furfurylamine biguanidine acetate (FBA) are new chemical antiseptics that have been developed by our group for the first time. With this research, we target to examine and investigate the antibacterial features of the new generation biguanidine derivatives against the multi-drug resistant Acinetobacter baumannii (MDRAb) strains. Method: Bactericidal efficacy was examined as per the DIN EN 1040 (DIN EN 1040, 2005) standard. A 5 log decrease in bacterial density was accepted as efficient. By the agar well diffusion method, the effects of FBC and FBA on the resistant Acinetobacter strains were investigated. Result: FBC and FBA were found as bactericidal efficient with 5 log decrease in bacterial density. FBC and FBA formed an inhibition zone of at least 15 mm in the 20 separate MDRAb strain disc diffusion tests. Conclusion: As FBC and FBA were isolated for the first time, they were deemed effective against MDRAb strains
Siyasetin renkli siması: Kamer Genç
No full textAnkara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2020.This work is a student project of the Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.The History of Turkey course (HIST200) is a requirement for all Bilkent undergraduates. It is designed to encourage students to work in groups on projects concerning any topic of their choice that relates to the history of Turkey. It is designed as an interactive course with an emphasis on research and the objective of investigating events, chronologically short historical periods, as well as historic representations. Students from all departments prepare and present final projects for examination by a committee, with 10 projects chosen to receive awards.Includes bibliographical references (pages 17-19).1940 yılında Tunceli'de dünyaya gelen Kamer Genç, Türk siyasi tarihinin en önemli ve renkli isimlerinden biriydi. Asıl mesleği mali müşavirlik olmasına rağmen sonradan Danıştay'ın sınavını kazanarak Danıştay tetkik hâkimi oldu. Donanımlı biri olması nedeniyle 1980 darbesi sonrasında isminin Danışma Meclisi'ne önerilmesinin ardından üye olarak Anayasa yapım çalışmalarına katıldı. Ardından çok partili siyasi hayatın yeniden başlamasıyla birlikte siyasete atılmaya karar verdi. Siyasi hayatında 18, 19, 20, 21 ve 23. dönemler olmak üzere toplamda beş dönem boyunca hem çeşitli partiler bünyesinde hem de bağımsız şekilde Tunceli milletvekilliği yaptı. Milletvekilliğinin yanı sıra bir yasama dönemi boyunca da Meclis Başkanvekilliği görevini üstlendi. Siyasette sivri kişiliği ve inandığı değerleri korumak adına takındığı muhalif tavırlarıyla kimi zaman çevreden tepki çekmiş olsa da Türk siyasi tarihinde sürekli gündemde kalmayı başaran ve en sevilen isimlerden biri haline geldi. Renkli kişiliği ile Türk siyasetine birçok anı bırakan Kamer Genç, pankreas kanseri nedeniyle 2016'da vefat etti.Kamer Genç was born in 1940 in Tunceli. He was one of the most important persons with his colorful personality in Turkish politics. Although his actual job was certified public accountant, he was successful at state council's (Danıştay) exam and he became a examination judge. Because he was a very knowledgeable person, after 1980 military coup he was recommended to the advisory council and he started to working on a constitution establishments. Then due to the multiple party political system, he entered politics. In his political life he was assigned as a deputy in Turkish parliament. He was not only a deputy of political parties but also was an independent deputy in one period. In addition to his deputy duty, he was assigned as parliamentary deputy speaker in one legislative session. Even he got reactions because of his sharp personality and dissenting manner in order to defend the values he believed, he was always remained on the agenda. Kamer Genç leaved so many memories to Turkish political life with his colorful personality and passed away in 2016 because of pancreas cancer.by Turaç Hakalmaz
Mardinli İki Büyük Tıp Doktoru: Prof. Dr. Aziz Sancar ve Prof. Dr. Murat Dilmener
No full textBu çalışmada; Mardinli ve İstanbul Üniversitesi İstanbul Tıp Fakültesi mezunu olan, başarılarıyla alanlarında zirvede yer alan; Prof. Dr. Aziz Sancar ile Prof. Dr. Murat Dilmener'in benzer ve farklı yönleri incelenmiştir. İkisi de aynı topraklardan çıkan bilim insanları olarak bilimsel ve insani niteliklerini bir arada sergilemişlerdir. Aziz Sancar, yurt dışında lisans üstü eğitim almış, yurt dışında olağanüstü başarılar elde etmiştir. Bu süreçte köklerine sıkı sıkıya bağlı kalmış, başarılarıyla öne çıkarken, memleketinin eğitimi için bütün varlığıyla vakıf kurarak öğrencilere destek olmuştur. Murat Dilmener ise İstanbul'da kalarak uluslararası alanda önemli başarılara imza atmış ve Türkiye'deki tıp eğitimine büyük katkılar sağlamıştır. Bir taraftan da hastalar ve öğrenciler için bütün imkanlarını seferber etmiş, bu alanda faaliyet gösterecek vakıf ve derneklerin kuruluşunda aktif görevler almıştır. Bu çalışmada, Prof. Dr. Aziz Sancar ve Prof. Dr. Murat Dilmener’in bilimsel ve insani vasıflarının bir arada ele alınması ve bu vesileyle, onların neden bilim tarihine geçen büyük hekimler olduğunun anlaşılması amaçlanmıştır. Her iki büyük bilim insanı hem bilimsel çalışmaları hem de insani yardımlarıyla ön plana çıkmış ve genç bilim insanlarına örnek olmuşlardır. Bu makalenin sonucunda, bilimin iyilik için kullanılması ve güzel niteliklerin bilimsel başarılarla birleştirilmesi sonucunda anlam kazanabileceği görülmüştür
Application of Stereology in Studying the Programming Consequences
No full textChanges during fetal development may have long-lasting consequences as Professor J. Barker observed and defined as a concept of programming or developmental origin of health and disease. This concept implies a linkage between adverse environmental signals during prenatal development and low birth weight as a marker, along with a greater incidence of pathophysiological conditions in postnatal life. Today, the programming concept becomes increasingly important because it explains the occurrence of many diseases during adulthood and include cardiometabolic, reproductive and mental disorders. During prenatal development periods of rapid cell division have been marked as critical since the establishment of the future structure and thus the function of tissues and organs are determined at these periods. Every change during these windows of vulnerability, that are organ specific, can influence developmental trajectory resulting in future or persistent malfunction. Glucocorticoids have been powerful modulators of gene expression and epigenetic modifications which control the proliferation and maturation of tissues to harmonize development with given environmental conditions. Acting on the tissue morphology and function in preparation for extrauterine life they promote nervous, respiratory, cardiovascular and immune system differentiation and biochemical maturation. Therefore, glucocorticoids as the main communicating signals between environment and developing organism represent a key link involved in the programming mechanism that shapes future physiology or predispositions to health or disease.
Design-based stereology remains one of the pillars of quantitative biomedical research. This modern methodological approach offers the possibility to obtain unbiased results of every aspect of an organ or tissue structure. The exact size of the structure, number and volume of cells or other constituent elements, length or surface of the studied structure can be unambiguously and accurately determined, in absolute terms by following the basic principles of stereological measurements. Combining histological analysis, and immunohistochemistry and/or immunofluorescence with quantitative microscopy as are stereological measurements and intensity of above-mentioned stainings, structural alterations can be measured and determined, enabling an understanding of the basic functional mechanisms of examined changes.
Changes that are the cause or consequence of programming in fetuses and offspring, respectively are the focus of this presentation. Prenatally, alterations of brain control centers, pituitary gland, adrenal, thyroid and reproductive axes, obtained by stereology will be presented. In offspring, the application of stereology provides physical evidence that structural changes of vide variety of tissues are the result of prenatal changes, showing that quantitative differences in early life evolve in qualitative i.e. functional problems later in life.Genç A, Turan S, editors. Book of Abstracts: 1st International Microscopy and Spectroscopy Congress and 25th National Electron Microscopy Congress: MSC 2021; 2021 Sep 22-24; Online. Turkish Society for Electron Microscopy; 2021. p. 23
Meslekte 50 yılını dolduran beden eğitimi öğretmenlerinin Anıtkabri ziyaretlerinde dernek başkammızın TBÖD adına Anıdefterine yazdığı yazı
No full textVatanımızın kurtarıcısı, cumhuriyetimizin kurucusu Başöğretmenimiz Aziz Atamız Mustafa Kemal Atatürk...Devrim ve ilkelerine bağlılığımızı yaşamımız boyunca genç kuşaklara aktardık. Bu duygularla mezuniyetimizin 50. yılında huzurunuza geldik.Saygılarımızı sunarız
Genç Yetişkinlerde Değer Tercihlerinin Narsistik Kişilik Özellikleri Yordaması
No full text#nofulltext# --- Güngör, İbrahim Halil (Arel Author)Bu araştırma yapısal eşitlik modeline göre genç yetişkinlerde değer tercihlerinin narsistik kişilik özelliklerini ne düzeyde yordadığının ortaya konulmasını amaçlamıştır. Araştırma 133 (%59.6) kadın ve 90 (%40.4) erkek olmak üzere toplam 223 genç yetişkinden (yaş ortalaması: 25.66, ranj: 20-38) oluşmaktadır. Katılımcıların seçiminde oranlı küme örnekleme yöntemi kullanılmıştır. Araştırmada veri toplama aracı olarak "Narsisizm Kişilik Ölçeği" ve "Schwartz Değerler Ölçeği"nden faydalanılmıştır. Teorik modelin yapısal eşitlik modeli bağlamında yol analizi ile test edilmesinde AMOS 16 programı kullanılmış ve istatistiksel işlemleri yapılmıştır. Araştırma sonucunda elde edilen bulgulara göre; güç, başarı, hazcılık, uyarılma, özdenetim ve evrensellik alt boyutlarının narsisizm üzerinde pozitif; yardımseverlik ve güvenlik alt boyutlarının ise narsisizm üzerinde negatif yönde etkiye sahip değer boyutları olduğu tespit edilmiştir. Görünenin aksine son derece zayıf ve güçsüz olan narsistik kişilikler, dış dünyaya karşı sürekli güç arayışı içinde olurlar. Bu da onları ötekine rağmen var olmaya iter. Oysa yardımseverlik ve güvenlik ihtiyacı insanı diğerlerini dikkate almaya ve diğeri ile beraber var olmaya zorunlu kılarBu araştırma yapısal eşitlik modeline göre genç yetişkinlerde değer tercihlerinin narsistik kişilik özelliklerini ne düzeyde yordadığının ortaya konulmasını amaçlamıştır. Araştırma 133 (%59.6) kadın ve 90 (%40.4) erkek olmak üzere toplam 223 genç yetişkinden (yaş ortalaması: 25.66, ranj: 20–38) oluşmaktadır. Katılımcıların seçiminde oranlı küme örnekleme yöntemi kullanılmıştır. Araştırmada veri toplama aracı olarak “Narsisizm Kişilik Ölçeği” ve “Schwartz Değerler Ölçeği”nden faydalanılmıştır. Teorik modelin yapısal eşitlik modeli bağlamında yol analizi ile test edilmesinde AMOS 16 programı kullanılmış ve istatistiksel işlemleri yapılmıştır. Araştırma sonucunda elde edilen bulgulara göre; güç, başarı, hazcılık, uyarılma, özdenetim ve evrensellik alt boyutlarının narsisizm üzerinde pozitif; yardımseverlik ve güvenlik alt boyutlarının ise narsisizm üzerinde negatif yönde etkiye sahip değer boyutları olduğu tespit edilmiştir. Görünenin aksine son derece zayıf ve güçsüz olan narsistik kişilikler, dış dünyaya karşı sürekli güç arayışı içinde olurlar. Bu da onları ötekine rağmen var olmaya iter. Oysa yardımseverlik ve güvenlik ihtiyacı insanı diğerlerini dikkate almaya ve diğeri ile beraber var olmaya zorunlu kıla
Dental follicle mesenchymal stem cells ameliorated glandular dysfunction in Sjögren’s syndrome murine model
No full textOBJECTIVE: Dental mesenchymal stem cells (MSCs) are potential for use in tissue regeneration in inflammatory diseases due to their rapid proliferating, multilineage differentiation, and strong anti-inflammatory features. In the present study, immunoregulatory and glandular tissue regeneration effects of the dental follicle (DF)MSCs in Sjögren’s Syndrome (SS) were investigated. METHODS: Dental follicle (DF) tissues were obtained from healthy individuals during tooth extraction, tissues were digested enzymatically and DFMSCs were cultured until the third passage. DFMSCs were labeled with Quantum dot 655 for cell tracking analysis. The induction of the SS mouse model was performed by the injection of Ro60-273-289 peptide intraperitoneally. DFMSCs were injected intraperitoneally, or into submandibular, or lacrimal glands. Splenocytes were analyzed for intracellular cytokine (IFN-γ, IL-17, IL-10) secretion in T helper cells, lymphocyte proliferation, and B lymphocyte subsets. Histologic analysis was done for submandibular and lacrimal glands with hematoxylin-eosin staining for morphologic examination. RESULTS: The systemic injection of DFMSCs significantly reduced intracellular IFN-γ and IL-17 secreting CD4+ T cells in splenocytes (p<0.05), and decreased inflammatory cell deposits and fibrosis in the glandular tissues. DFMSCs differentiated to glandular epithelial cells in submandibular and lacrimal injections with a significant reduction in lymphocytic foci. The results showed that few amounts of DFMSCs were deposited in glandular tissues when applied intraperitoneally, while high amounts of DFMSCs were located in glandular tissues and differentiated to glandular epithelial cells when applied locally in SS murine model. CONCLUSION: DFMSCs have the potential for the regulation of Th1, Th17, and Treg balance in SS, and ameliorate glandular dysfunction. DFMSCs can be a beneficial therapeutic application for SS
O sevdalı, kükreyen, çalışkan, her daim genç yürek altı yıl önce durmuştu:Aziz Nesin'e olan borcumuz
No full textTaha Toros Arşivi, Dosya No: 56-Aziz Nesin. Not: Ekte Aziz Nesin'e ait şiir bulunmaktadır
Avanos-Akarca’da Bulunan bir Orta Tunç Çağı Steli
No full textDuring a digging operation for a water channel near Akarca village in Nevşehir-Avanos, a stone with some reliefs was discovered by the local villagers in 2014. News regarding the discovery of the stone aroused questions, thereafter the stele was almost immediately delivered to the museum of Anatolian Civilizations in Ankara by the author and Uğur Yanar. This stone possesses a rounded top and four flattened faces which belong to the upper part of a basalt stele. It was broken off from the lower part of stele; it is 57.5 cm high, 34.5 cm wide and 20.5 thick. The figures are depicted in the low relief technique on four of the faces and on the rounded top of the artifact. The main theme of these depictions on the stele have a religious content. A standing god whom is offered (offered what?) by two figures under a sun disc with a crescent relief are depicted on the front face of this stele. On its reverse side, a banquet scene including two gods (?) who are sitting face to face and an attendant serving them is carved. On the left side of the stele is a winged god is depicted under the mountains and, on its right side, a bull and the Storm God holding the bull’s halter is shown standing on the mountains. The rounded top of the stele is completely decorated with mountains.
The style and the iconographic features of figures in the Avanos-Akarca stele is unique to Anatolia; it seems that some aspects of Old Syrian arts are reflected on this artifact. The god wearing a pointed cap on the front side of stele and the banquet scene with an altar on its reverse side resemble the depictions on two cultic basins from the B1 and D Temples of Ebla (Tell Mardikh), dated to ca.1900-1800 B.C. The figure with the pointed cap also appears on the golden plaque from Byblos. The figures with pointed caps depicted in the Old Syrian style are also found on the seal impressions from Level II of Kültepe / Kaneš-Karum in Anatolia. These figures appear as both the king and the god in these seal impressions. The depictions resembling mountains on both sides of the stele and on the top side are depicted on the skirt of a statue from Mari. Because of the thematic and stylistic similarities between the figures of the stele and the finds from Ebla, Byblos and Kültepe / Kaneš-Karum, this stele can be dated to1900-1800 B.C.
The stele was discovered in the corner of a wall built with clean cut stones by villagers during the digging of a water channel. According to scholarly statements, the stele was probably used as a gathering material in the wall of a building. When this piece of stele arrived in Avanos-Akarca, and how it was carried there are questions that are yet to be answered. The Avanos-Akarca stele and Harput relief are one of the lesser known stone monuments with reliefs from the Middle Bronze Age.T.C. Kültür ve Turizm Bakanlığı
The Turkish Republic Ministry of Culture and Tourism
Kültür Varlıkları ve Müzeler Genel Müdürlüğü
General Directorate of Cultural Assets and Museums
Kayseri Valiliği
Kayseri Governorship
Türk Tarih Kurumu
The Turkish Historical Society
Ankara Üniversitesi
Ankara University
Kayseri Büyükşehir Belediyesi Başkanlığı
Kayseri Metropolitan Municipalit
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