2,061 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
Analysis of 6G and B5G waveforms using hybrid MF-ED and ECG-ED spectrum sensing techniques
No full textThe rapid evolution of wireless communication has necessitated advanced waveform analysis for beyond-fifth-generation (B5G) and sixth-generation (6G) radio networks, focusing on efficient spectrum utilization. There is a need for greater spectrum allotment in data-intensive applications, and new technologies require faster data rates and reduced latency. This study explores hybrid spectrum sensing techniques, combining matched filter (MF) energy detection (ED) and an equal-gain combining-based energy detection Neyman-Pearson threshold estimation technique (EGC-ED-PTh) to enhance waveform detection accuracy in complex environments. The proposed method offers an enhanced signal-to-noise ratio (SNR) by optimizing the detection performance, particularly in low-SNR environments, thereby improving the signal reliability. The proposed algorithms are evaluated in comparison with traditional SS methods, including ED, MF, and cyclostationary feature detection (CFD). Additionally, characteristics including bit error rate (BER), power spectral density (PSD), probability of detection (pd), and probability of false alarm (pfa) were researched and evaluated for 500 and 1000 samples. The simulation findings show that the projected algorithms perform better than the traditional algorithms with minimum sidelobes of – 3024 and pfa effects and achieve a throughput gain of 5 and 4.7 dB compared with the conventional algorithms
Characterization of product properties in thermophilic compost from oil palm wastes / Nurul Norhidayah Aziz
No full textThis study aims to introduce a method for the production of products resulting from the use of palm oil mill residues consisting of MF (mesocarp fiber), POME (Palm Oil Mill Effluent), EFS (Empty Fruit Bunch) and a mixture of all three waste oil through thermophilic compo sting process. Reviews for 5 weeks with the use of machines located in the Research Center decomposition Universiti Kebangsaan Malaysia (UKM) in Tasik Chini , Pahang. Rendering engine has been set at a temperature between 50°C-60°C. Specification properties thermophilic compost products in terms of physical characteristics of the product and nutrient content were performed. The results show that there is a change in the physical characteristics of some oil palm waste. In addition, the comparison of nutrient between thermophilic compost with normal compost has shown that almost all POME nutrient content in normal compost higher than thermophilic compost. However studies on the EFB showed opposite results. While studies on the MF only visible decomposition of N content of compost to normal thermophilic compost due to lack of research data. In conclusion, the thermophilic compost suitable as fertilizer because it provides content that can help plant nutrient
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Hybrid Spectrum Sensing Using Neural Network–Based MF and ED for Enhanced Detection in Rayleigh Channel
No full textSpectrum sensing (SS) is an integral part of cognitive radio systems, allowing for dynamic spectrum access and efficient exploitation of scarce spectral resources. Classic spectrum sensing methods, such as matched filters (MFs) and energy detections (EDs), usually fail in low-SNR and interference-rich scenarios, with poor detection performance and suboptimal spectrum usage. This work proposes a hybrid spectrum sensing approach that combines the neural network (NN)-based MF and ED to address these limitations. The NNs act as an intelligent signal processor that uses its ability to learn and adapt to different channel conditions to enhance signal detection in low-SNR environments. The proposed framework combines the accuracy of MF with the adaptability of ED, guided by a NN to improve decision-making accuracy. Extensive simulations demonstrate that the method achieves significant improvements in detection accuracy, false alarm reduction, and spectrum hole identification compared to traditional approaches. Furthermore, the capability of the NN to mitigate noise and interference results in enhanced bit error rate (BER) performance, ensuring reliable communication. The paper assesses the system performance in terms of the key metrics, BER, probability of detection (Pd), and probability of false alarm (Pfa), power spectral density (PSD), and capacity, thereby indicating robustness toward dynamic and noisy environments. The results, therefore, open up a potential for defining spectrum sensing by NNs as a scalable, adaptive, and efficient solution for future wireless communication systems in applications such as IoT, 5G, and next-generation cognitive radios
Characterization Of The Homologs Of A Diagnostically Significant Brugia Malayi Gene (Bm17DIII) In Wuchereria Bancrofti, Loa Loa and Onchocerca Volvulus [RA644.F5 R788 2007 f rb].
No full textSatu ujian pantas yang dikenali sebagai BRUGIArapid (BR) yang mengesan antibodi IgG4 terhadap antigen rekombinan B. malayi (BmR1) adalah sangat berguna dalam pemetaan dan pengawasan kawasan yang endemik bagi filariasis brugia.
An antibody-detection rapid test, BRUGIArapid, that detects IgG4 antibodies reactive to a recombinant B. malayi antigen (BmR1), is a promising tool for mapping and monitoring the areas where brugian filariasis is endemic
Signal detection of M-MIMO-orthogonal time frequency space modulation using hybrid algorithms: ZFE + MMSE and ZFE + MF
No full textOrthogonal Time Frequency Space (OTFS) modulation, coupled with Massive Multiple Input Multiple Output (Massive-MIMO) technology, presents a promising avenue for enhancing the efficiency and reliability of fifth-generation (5G) and beyond fifth-generation (B5G) systems. OTFS modulation offers robust communication in high-mobility environments by converting signals into the delay-Doppler domain, ensuring better performance over fading channels. MIMO enhances wireless networks by using large antenna arrays to boost capacity, spectral efficiency, and reliability, making both technologies vital for next-generation radio systems. In this study, we explore the detection of (8 × 8, 16 × 16, 64 × 64, and 256 × 256) Massive-MIMO-OTFS signals utilizing two prominent detection algorithms: zero forcing equalization (ZFE) with matched filter (MF) known as (ZFE + MF) and Zero Forcing with minimum mean square error (MMSE) known as (ZFE + MMSE). The combination of Massive MIMO and OTFS offers improved spectral efficiency, robustness against fading, and enhanced spatial multiplexing capabilities. The parameters such as bit error rate (BER) and power spectral density (PSD) are analyzed and estimated for the proposed hybrid and conventional algorithms. The proposed algorithms obtained the SNR and PSD gain of 3.2 dB, 3.2 dB, 4.8 dB, and 6.1 dB gain, respectively, for 8 × 8, 16 × 16, 64 × 54, and 256 × 256 MIMO systems. Further, the PSD gain of -390 is obtained for the 256 × 256 system, resulting in high spectral efficiency
Identification of serine 867 as new phosphorylation site on the GABA(B) receptor : characterization of physiological effects
No full textThe GABAB receptor is the metabotropic receptor for γ-aminobutyric acid (GABA), the main inhibitory
neurotransmitter in the mammalian central nervous system (CNS). The functional receptor is a
heteromer consisting of a GABAB1 and GABAB2 subunit. Two isoforms from the GABAB1 subunit exist;
the GABAB1a and the GABAB1b isoform, whose distribution pattern differs throughout the brain. GABAB
receptors manifest their inhibitory action by influencing adenylate cyclase activity, presynaptic
voltage sensitive Ca2+ channels and postsynaptic rectifying K+ channels. The large variety of
neurological and psychiatric disorders e.g. addiction, epilepsy, nociception and depression caused by
GABAB receptors dysfunctions, highlight the importance for GABAB regulatory mechanisms. One such
regulatory mechanism is phosphorylation which is the principal way to regulate GABAB receptor
functioning. In vivo, two phosphorylation sites on GABAB receptors were identified; serine 892 and
serine 783 and both sites play a role in synaptic plasticity. Phosphorylation of serine 892 prolongs
the inhibitory impact of GABAB receptors activity on the CNS and serine 783 is ascribed for its
neuroprotective benefits.
The aim of this thesis was to study the modulatory effect of phosphorylation on GABAB receptor
functioning. The identification of serine 867, a novel physiological relevant phosphorylation site on
GABAB receptors, contrasts with the previous serine sites. Indeed, the serine 867 is positioned on the
GABAB1 subunit, constrasting with the GABAB2 localisation of the serines 892 and 783. Interestingly,
serine 867 phosphorylation is mediated by CaMKII, an abundant and relevant kinase in the CNS.
Consequently, it is proposed that serine 867 phosphorylation could regulate surface availability of
GABAB receptors under neuronal activation leading to synaptic plasticity modulation
- …
