1,720,990 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Experimenteller Ansatz zur Untersuchung von Konformationsänderungen in Proteinen mit Hilfe von Biotinderivaten und Massenspektrometrie
No full textThe biotinylation patterns of two soluble model proteins (BSA and CA II) were analyzed under different conditions. In a first step these proteins were biotinylated with an increasing molar excess of a biotin derivative. In this case increases in biotin concentration led to an increase in the number of biotinylated lysine residues until a point of saturation was reached. A further increase in biotin concentration did not result in additional lysine residues being biotinylated. The biotinylation pattern was reproducible and under any given conditions, only specific lysine residues are biotinylated.
After showing that the biotinylation of proteins is specific and reproducible, the same approach was used to map artificially induced conformation changes in BSA and CA II. These proteins were subjected to elevated temperatures that induce conformation changes. The biotinylation pattern of these proteins at room temperature and after exposure to 80°C was compared. For BSA, heating results in the biotinylation of two additional lysine residues. This is most likely due to conformation changes in the protein structure induced by the high temperature. In the case of CA II there was no difference in the biotinylation pattern of the protein at room temperature and at 80°C.Having established that biotinylation patterns can be used to reliably detect conformational changes in protein structure, the biotinylation pattern of Band III (a transmembrane protein of the human erythrocyte plasma membrane) in infected and noninfected erythrocyte was analyzed. These experiments confirmed previous observations that this protein undergoes a conformational change upon infection. The biotinylation pattern was different between RBC and IRBC in respect to a single lysine residue which is biotinylated only in RBC. These results suggest that, upon invasion by P. falciparum, the Band III protein undergoes conformation changes which are probably important for the survival of the parasite within the host cell.Das Biotinylierungsmuster zweier löslicher Proteine (BSA und CA II), sowie das des Erythrozytenmembranproteins Bande III wurde unter unterschiedlichen Bedingungen analysiert. Im ersten Schritt wurden diese Proteine mit einem Überschuss an Biotin in einem molaren Verhältnis biotinyliert. Für die löslichen Proteine führt eine Erhöhung der Biotinkonzentration zu einer Zunahme der Anzahl an biotinylierten Lysinresten bis zu einem Punkt der Sättigung. Eine weitere Erhöhung der Biotinkonzentration führt nicht zu zusätzlich mit Biotin markierten Lysinresten. Das Biotinylierungsmuster dieser beiden löslichen Proteine ist reproduzierbar und zeigt unter allen gewählten Bedingungen eine Biotinylierung spezifischer Lysinreste. Nachdem gezeigt war, dass die Biotinylierung der Proteine spezifisch und reproduzierbar ist, wurde die gleiche Methode gewählt, um künstlich verursachte Konformationsänderungen in BSA und CA II anhand eines veränderten Biotinylierungsmusters zu zeigen. Diese Proteine wurden erhöhten Temperaturen ausgesetzt, um eine Konformationsänderung hervorzurufen, und anschliessend wurden die Biotinylierungsmuster bei Raumtemperatur und 80 °C miteinander verglichen. Bei BSA führt die Erhitzung auf 80 °C zu einer Biotinylierung von zwei zusätzlichen Lysinresten. Dabei ist es wahrscheinlich, dass die durch die Erwärmung verursachte Konformationsänderung die beobachtete Änderung des Biotinylierungsmusters zur Folge hat. Im Fall von CA II gibt es keinen Unterschied das Biotinylierungsmusters zwischen Raumtemperatur und 80 °C.
Da es Hinweise dafür gibt, dass sich die Konformation des Bande III Proteins in der Plasmamembran von Erythrozyten nach einer Infektion mit P. falciparum verändert, wurden intakte infizierte und nichtinfizierte Erythrozyten biotinyliert, um etwaige Unterschiede in den Biotinylierungsmustern festzustellen. Das Biotinylierungsmuster des Proteins unterschied sich zwischen RBC und IRBC nur in einem einzelnen Lysinrest, der nur in RBC biotinyliert ist. Diese Beobachtung bestätigt die Annahme, dass Bande III nach der Infektion durch P. falciparum eine Konformationsänderung erfährt und erlaubt es, die Position dieser Veränderung einzugrenzen
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
- …
