3 research outputs found
Problematic Issues of Forensic Examinations in the Detection and Investigation of Crimes on Illicit Trafficking of Narcotic Drugs of Plant Origin
No full textThe article discusses the main trends in the illegal trafficking of plants containing psychoactive substances of the hallucinogen class. The author reveals the features of hallucinogens and dissociative anesthetics. The article also provides statistical indicators of the consumption growth of new psychoactive substances, including those contained in plant objects. The main criteria by which plant objects fall under the constructive apparatus of illegal trafficking are identified. The author pays special attention to applying specialized knowledge to expert identification and diagnostics of plants withdrawn from illicit trafficking containing narcotic drugs or psychotropic substances or their precursors. To counteract the illegal trafficking of narcotic plants, the author proposes measures to improve the operational algorithms of experts’ actions when investigating herbal narcotic drugs. On the example of plants species Banisteriopsis caapi, the author demonstrates the lack of the study of taxonomic units of tropical plants containing hallucinogens. To solve this problem, the author proposes to change the level of definition of taxonomic affiliation from species to generic in the List of Plants containing narcotic drugs or psychotropic substances or their precursors
Проблемные вопросы идентификационных и диагностических исследований (судебных экспертиз) при выявлении и расследовании преступлений в сфере незаконного оборота наркотических средств растительного происхождения
No full textThe article discusses the main trends in the illegal trafficking of plants containing psychoactive substances of the hallucinogen class. The author reveals the features of hallucinogens and dissociative anesthetics. The article also provides statistical indicators of the consumption growth of new psychoactive substances, including those contained in plant objects. The main criteria by which plant objects fall under the constructive apparatus of illegal trafficking are identified. The author pays special attention to applying specialized knowledge to expert identification and diagnostics of plants withdrawn from illicit trafficking containing narcotic drugs or psychotropic substances or their precursors. To counteract the illegal trafficking of narcotic plants, the author proposes measures to improve the operational algorithms of experts’ actions when investigating herbal narcotic drugs. On the example of plants species Banisteriopsis caapi, the author demonstrates the lack of the study of taxonomic units of tropical plants containing hallucinogens. To solve this problem, the author proposes to change the level of definition of taxonomic affiliation from species to generic in the List of Plants containing narcotic drugs or psychotropic substances or their precursors.В статье рассматриваются основные тенденции нелегального оборота растений, содержащих психоактивные вещества класса галлюциногенов. Раскрываются особенности галлюциногенов и диссоциативных анестетиков. Приводятся статистические показатели роста потребления новых психоактивных веществ, в том числе содержащихся в растительных объектах. Выявляются основные критерии, по которым растительные объекты подпадают под конструктивный аппарат незаконного оборота. Особое внимание уделяется использованию специальных знаний для экспертной идентификации и диагностики изъятых из незаконного оборота растений, содержащих наркотические средства или психотропные вещества либо их прекурсоры. Для противодействия незаконному обороту наркосодержащих растений предлагаются меры по совершенствованию операционных алгоритмов действий экспертов, исследующих растительные наркотические средства. На примере растений вида Banisteriopsis caapi показана недостаточная изученность таксономических единиц тропических растений, содержащих в своем составе галлюциногены. Решение проблемы предлагается путем изменения в Перечне растений, содержащих наркотические средства или психотропные вещества либо их прекурсоры, уровня определения таксономической принадлежности растений с видовой на родовую
Dimerization of long hibernation promoting factor from Staphylococcus aureus: Structural analysis and biochemical characterization
No full textInternational audienceStaphylococcus aureus hibernation promoting factor (SaHPF) is responsible for the formation of 100S ribosome dimers, which in turn help this pathogen to reduce energy spent under unfavorable conditions. Ribosome dimer formation strongly depends on the dimerization of the C-terminal domain of SaHPF (CTDSaHPF). In this study, we solved the crystal structure of CTDSaHPF at 1.6 Å resolution and obtained a precise arrangement of the dimer interface. Residues Phe160, Val162, Thr171, Ile173, Tyr175, Ile185 andThr187 in the dimer interface of SaHPF protein were mutated and the effects were analyzed for the formation of 100S disomes of ribosomes isolated from S. aureus. It was shown that substitution of any of single residues Phe160, Val162, Ile173, Tyr175 and Ile185 in the SaHPF homodimer interface abolished the ribosome dimerization in vitro
