1,720,958 research outputs found
PENATALAKSANAAN MALIGNANT FIBROUS HISTIOCYTOMA
Get PDFAbstrakMalignant fibrous histiocytoma (MFH) merupakan sarkoma jaringan lunak yang banyak ditemukan terutama pada ekstremitas, yaitu 70%-75%. Munculannya berupa massa kelenjar tumor jaringan lunak, besar, dan tidak nyeri. Keadaan ini lebih sering ditemukan pada orang kulit putih dibandingkan dengan kulit hitam. Insiden banyak terjadi pada dekade kelima sampai keenam, dengan metastasis hematogen lebih sering dijumpai. Untuk diagnosis yang definitif diperlukan biopsi yang adekuat, dan untuk eksistensi tumor digunakan CT-Scan/MRI. Untuk diagnosis klinis sangat diperlukan GTNM staging. MFH sangat tidak berespon terhadap adjuvant terapi, oleh karena itu tindakan operatif yang pertama kali sangat menentukan prognosis penderita.Kata Kunci : Malignant Fibrous Histiocytoma - GTNMAbstractMalignant fibrous hystiocytoma (MFH) is a soft tissue sarcoma found mostly (70%-75%). in the extremities. It appears as a mass of large and painless glandular tumor of soft tissue. MFH is found mostly in white people, during fifth and sixth decade of life. Hematogenous metastasis is found more often. For definitive diagnosis, incisional biopsy was needed, and its existence is detected using with CT-Scan/MRI. Clinical diagnosis requires GTNM staging system. MFH is not responsive to adjuvant therapy, therefore the first surgical operation is crucial in defining the patient prognosis.Keywords; Malignant Fibrous Hystiocytoma, GTNMTINJAUAN PUSTAKA</p
PENATALAKSANAAN MALIGNANT FIBROUS HISTIOCYTOMA
Get PDFAbstrakMalignant fibrous histiocytoma (MFH) merupakan sarkoma jaringan lunak yang banyak ditemukan terutama pada ekstremitas, yaitu 70%-75%. Munculannya berupa massa kelenjar tumor jaringan lunak, besar, dan tidak nyeri. Keadaan ini lebih sering ditemukan pada orang kulit putih dibandingkan dengan kulit hitam. Insiden banyak terjadi pada dekade kelima sampai keenam, dengan metastasis hematogen lebih sering dijumpai. Untuk diagnosis yang definitif diperlukan biopsi yang adekuat, dan untuk eksistensi tumor digunakan CT-Scan/MRI. Untuk diagnosis klinis sangat diperlukan GTNM staging. MFH sangat tidak berespon terhadap adjuvant terapi, oleh karena itu tindakan operatif yang pertama kali sangat menentukan prognosis penderita.Kata Kunci : Malignant Fibrous Histiocytoma - GTNMAbstractMalignant fibrous hystiocytoma (MFH) is a soft tissue sarcoma found mostly (70%-75%). in the extremities. It appears as a mass of large and painless glandular tumor of soft tissue. MFH is found mostly in white people, during fifth and sixth decade of life. Hematogenous metastasis is found more often. For definitive diagnosis, incisional biopsy was needed, and its existence is detected using with CT-Scan/MRI. Clinical diagnosis requires GTNM staging system. MFH is not responsive to adjuvant therapy, therefore the first surgical operation is crucial in defining the patient prognosis.Keywords; Malignant Fibrous Hystiocytoma, GTNMTINJAUAN PUSTAK
PERBANDINGAN PROGNOSIS SUBTIPE MOLEKULER KANKER PAYUDARA ANTARA PASIEN KANKER PAYUDARA WANITA USIA MUDA DAN TUA DI RSUP DR. M. DJAMIL PADANG
Get PDFAbstrakPenelitian sebelumnya menunjukkan bahwa subtipe molekuler kanker payudara memiliki perbedaan distribusi dan efek prognostik antara usia muda dan tua, sedangkan data lokal maupun nasional tidak ada penulis temukan. Metode : Penelitian komparatif dengan metode cross sectional. Dilakukan bulan Januari – April 2015, sampel 96 penderita kanker payudara wanita usia ≤ 40 tahun dan > 40 tahun yang tercatat di rekam medis dan registrasi kanker payudara dari tahun 2012 – 2014. Hasil : Kejadian kanker payudara wanita usia muda di RSUP dr. M. Djamil Padang selama 3 tahun (2012-2014) yaitu 27,1% dan usia tua 72,9%. Analisa bivariat tidak menunjukkan hubungan yang signifikan antara berbagai karakteristik tumor dengan kejadian residif dan meninggal pada usia muda. Sedangkan pada usia tua, terdapat hubungan yang signifikan antara ukuran tumor dan metastasis terhadap kejadian residif dan meninggal. Kesimpulan : Ada perbedaan karakteristik dan gambaran subtipe molekuler kanker payudara antara usia muda dan tua, usia muda tumor cenderung berukuran besar, kelenjar getah bening positif, adanya invasi limfovaskuler, grade tumor tinggi, indeks proliferasi Ki67 tinggi serta reseptor hormon negatif. Terdapat kecenderungan perbedaan prognosis kanker payudara wanita antara usia muda dan tua berdasarkan subtipe molekuler namun tidak bermakna secara statistik.AbstractPrevious study showed that molecular subtypes of breast cancer have different distribution and prognostic effect between the young and adult, whereas it cannot found in the local and national data. Method : Comparative research with cross sectional design. Held in January-April 2015, Ninety six samples of breast cancer women with age ≤ 40 years old and > 40 years old that has been recorded in medical records and breast cancer registration from year 2012-2014. Result : Breast cancer that happened to young women at General Hospital dr. M. Djamil Padang for 3 years (2012-2014) are 27,1% and the adult are 72,9%. In bivariat analysis, there are not relationship between characteristics of tumor with recurrent and death while in the adult women breast cancer, tumor size and metastases have relation with recurrent and death that are significant statistically. Conclusion : There are different characteristics and description of breast cancer molecular subtype between young and adult women, young ages are tend to have big tumor, lymph node positive, lymphovascular invasion, high grade tumor, proliferation index Ki67 high and negative hormone receptor. There are differences tendency of prognosis women breast cancer between the young and adult based on molecular subtype but statistically, the relationship is not significant.<br /
Mixoid Liposarcoma
Get PDFAbstrak Sarkoma adalah pertumbuhan maligna jaringan mesodermal (jaringan ikat, otot, tulang). Liposarkoma adalah tumor ganas atau kanker pada jaringan lemak, yang biasanya dicirikan oleh adanya diferensiasi abortif sel – sel menjadi liposit dan merupakan tipe yang paling umum dari sarkoma jaringan lunak, muncul perlahan, membesar, tanpa rasa sakit, massa submukosa nonulserasi pada usia paruh baya. Jika terdeteksi lebih dini maka angka keberhasilan pengobatan menjadi lebih baik. Wide eksisi tumor merupakan modalitas pilihan pada penatalaksanaan Liposarkoma. Diagnosis ditegakkan berdasarkan riwayat perjalanan penyakit, pemeriksaan fisik dan pemeriksaan patologi anatomi. Dilaporkan satu kasus laki-laki berusia 74 tahun dengan diagnosis Miksoid Liposarkoma dilakukan Wide Eksisi Tumor tanpa pemberian Neo Adjuvan Terapi terlebih dahulu menunjukan perbaikan yang cukup signifikan Kata kunci: Sarkoma, Miksoid Liposarkoma, Wide Eksisi Tumor, Neo Adjuvan Terapi AbstractSarcoma is the growth of malignancy mesodermal tissue (connective tissue, muscle, bone). Liposarcoma is malignant tumor or cancer at fatty tissue, characterized by abortif differentiated cells to lipocyte and the common type of soft tissue sarcoma, appearing slowly, enlarged, painless, nonulceratif mass submucosal at the middle age. If the early detected the cure rate can be better. Wide Excision Tumor is the modality for treatment of Liposarcoma. The clinical diagnosis is made based on history of illness, physical examination and anatomical pathology examination. Reported One case, man 74 year old, diagnosed with Mixoid Liposarcoma treated by Wide Excision Tumor without given Neo Adjuvan Theraphy before showed a significant improvement. Keywords: Sarcoma, Mixoid Liposarcoma, Wide Eksisi Tumor, Neo Adjuvan Theraphy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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