668 research outputs found
sj-docx-1-tam-10.1177_17588359231177018 – Supplemental material for Safety of Lutetium-177 prostate-specific membrane antigen-617 (PSMA-617) radioligand therapy in the setting of severe renal impairment: a case report and literature review
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359231177018 for Safety of Lutetium-177 prostate-specific membrane antigen-617 (PSMA-617) radioligand therapy in the setting of severe renal impairment: a case report and literature review by Duncan E. K. Sutherland, Raghava Kashyap, Price Jackson, James P. Buteau, Declan G. Murphy, Brian Kelly, Lavinia Spain, Shahneen Sandhu, Arun A. Azad, Elizabeth Medhurst, Grace Kong and Michael S. Hofman in Therapeutic Advances in Medical Oncology</p
Targeting DNA-dependent protein kinase promotes accelerated senescence of irradiated human cancer cells
No full text© 2012 Dr. Arun AzadIonizing radiation is a widely used anti-cancer modality. Unfortunately however, relapse rates are high following radiation treatment indicating an urgent need for novel radiosensitizing strategies. Since radiation potently induces DNA double-strand breaks (DSBs), targeting signaling networks involved in DSB repair is a promising approach for enhancing cellular radiosensitivity. In mammalian cells the primary repair mechanism of radiation-induced DSBs is the non-homologous end-joining (NHEJ) pathway, in which DNA-dependent protein kinase (DNA-PK) plays a critical role. As a result, DNA-PK potentially represents an important molecular target for inhibiting DSB repair and enhancing the cytotoxicity of radiation.
Using BEZ235, a novel small molecule inhibitor of DNA-PK and phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) currently in clinical trials, the first aim of this thesis was to characterize the effects of inhibiting DNA-PK on tumor radiosensitivity in vitro and in vivo. The second aim of this thesis was to examine the mechanisms through which DNA-PK inhibition improves tumor radiosensitivity as little is known about the mechanisms involved in the radiation-enhancing effects of DNA-PK blockade.
BEZ235 was seen to abrogate radiation-induced DSB repair and potently increase the radiosensitivity of H460 and A549 cells, human non-small cell lung cancer (NSCLC) cell lines. BEZ235 also potentiated the anti-tumor activity of ionizing radiation in H460 xenografts. Significantly, radiation enhancement by BEZ235 coincided with a prominent p53-dependent accelerated senescence phenotype characterized by positive β-galactosidase staining, G2-M cell-cycle arrest, enlarged and flattened cellular morphology, increased p21 expression and senescence-associated cytokine secretion.
Subsequent experiments sought to examine the mechanisms involved in the pro-senescence response of irradiated cells to BEZ235, and specifically whether selective inhibition of DNA-PK is sufficient to promote accelerated senescence after radiation. Significantly, it was shown that specific pharmacological inhibition of DNA-PK but not PI3K or mTORC1 delays DSB repair leading to accelerated senescence after radiation. It was additionally demonstrated that PRKDC knock down using small interfering RNA promotes a striking accelerated senescence phenotype in irradiated cells comparable to that of BEZ235.
Collectively, these data establish accelerated senescence as a novel mechanism of radiosensitization induced by DNA-PK blockade and underline the emerging link between unrepaired DSBs and enforcement of p53-dependent accelerated senescence. These data highlight the potential benefits of using DNA-PK blockade to modulate repair of therapeutically-induced DSBs and thereby promote radiation-induced accelerated senescence. In turn, these findings provide a rationale for further pre-clinical and clinical evaluation of DNA-PK inhibitors in combination with anti-cancer agents that induce DSBs or inhibit DSB repair
Health Risks of Stress, Anxiety, and Depression and the Effectiveness of Yoga in Distress Reduction in Adolescents Studying in Schools Located in the Field Practice Area of a Tertiary Care Institution, Kanchipuram. a Randomized Control Trial.
No full textBackground: The adolescent age group is more prone to depression anxiety stress and other mental health conditions due to the transitional effect of their age group. The present study aims to assess their distress and to determine the impact of yoga on distress reduction compared to lifestyle education.
Methods and materials: The present experimental study was conducted among school-going adolescents from two publicly funded schools of the panchayat in the Southern part of India. A cluster random sampling was done to select the estimated sample size of 300 adolescents. Data were collected by interview method using a self-designed questionnaire. The mental distress was assessed using the DASS-10 questionnaire. Univariate analyses and student t-test analyses were done by Stata 17.
Results: More than one-third of the study participants 110 (36.66%) had distress in baseline data. On univariate analysis, it was found that female gender (p<0.05); father\u27s education below high school level (p<0.001); lower socioeconomic status (p<0.001); joint family (p<0.001); living in urban setup (p<0.001); underweight (p<0.05); addictive status of the father (p<0.001); stressful events in the family (p<0.001); more than one siblings (p<0.001); unsatisfied academic performance (p<0.001) and binge eating (p<0.001) were found to be significantly related to distress among adolescents. In the pretest, distress was seen in 61 (40.6%) adolescents which was reduced to 39 (26%) in the post-test after the yoga session in the intervention arm. Thus 35.97% decrease in distress was noted in the intervention arm which was significant when compared to a 24.53% distress reduction in the control group.
Conclusion: As yoga intervention substantially reduced the prevalence of distress, it is recommended that yoga be made a compulsory weekly activity in the adolescent\u27s education curriculum alongside conventional physical training classe
Understanding the value-chain of counterfeit products: A multimethod investigation
No full textThe student, - Sreekumar Arun, accepted the attached license on 2021-04-13 at 23:09.The student, - Sreekumar Arun, submitted this Dissertation for approval on 2021-04-13 at 23:23.This Dissertation was approved for publication on 2021-04-15 at 11:53.DSpace SAF Submission Ingestion Package generated from Vireo submission #16317 on 2021-09-16 at 17:03:02Made available in DSpace on 2021-09-17T02:34:25Z (GMT). No. of bitstreams: 2
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Previous issue date: 2021-04-15Embargo set by: Seth Robbins for item 118507
Lift date: 2023-09-17T02:34:57Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I OnlyThe context of this dissertation is the market for counterfeit products, which accounts for more than one trillion US dollars of trade globally every year. Entrepreneurs who manufacture and market these products are clandestine and operate in the black market. Drawing from this context, this dissertation seeks to advance knowledge on how entrepreneurs strategically use ambiguity in marketing communications, and in relationships with other firms. The first essay examines how and why equivocation is used as a persuasive strategy by sellers of counterfeit products. This essay develops a framework that can help qualitatively and quantitatively identify equivocation rhetoric in firm-generated text. The second essay examines how relationships between firms are managed when one of the firms employs ambiguity as a protection strategy. Specifically, the essay sheds light on how manufacturers and retailers of counterfeit products succeed in maintaining ambiguity, and in managing relationship tension arising from ambiguity. Put together, the essays present an investigation of how counterfeit manufacturers and retailers conduct their marketing functions despite being clandestine and illegal.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-0
Assessing the Effectiveness of Preoperative Intravenous Clindamycin versus Intravenous Metronidazole in prevention of Dry socket in Surgical Extraction of Impacted Mandibular Third Molar: A Prospective Comparative Study
No full textIntroduction: Alveolar osteitis or fibrinolytic osteitis is commonly referred as dry socket, is a condition that is a possible complication of extraction and surgical disimpaction.Dry socket is when the extraction socket is exposed and the clot that is to be covering it post extraction has been dislodged.The ethology of dry socket is multifold and has many contributing factors like infection, inflammation, or the nature of the extraction..
Objectives: To assess the efficacy of preoperative antibiotic administration of metronidazole and Clindamycin in surgical extraction of mandibular third molar extraction
Methods: 50 patients visiting the Oral and Maxillofacial surgery department for the surgical extraction of mandibular thrid molar were selected and assigned into two groups after consent and approval was taken explaining them in detail the procedure. Group 1 was administered 400mg of metronidazole IV one hour prior to the surgery and group 2 was administered 300mg of Clindamycin IV one hour prior to the surgery. Both groups were instructed to take analgesics twice a day for 5 days, and to report back after 7 days for review or to report back immediately in case of severe pain
Results: The incidence of Dry socket in both the groups were not statistically significant and were similar to previous reports of literature
Conclusions: In this study, it was found that administering a single dose of Clindamycin intravenously before surgery did not decrease the occurrence of dry socket. However, it was found to be just as effective as a single preoperative intravenous dose of metronidazole. This suggests that Clindamycin is a dependable and efficient option for patients who are allergic to the nitroimidazole grou
Author Correction: A shared neural basis underlying psychiatric comorbidity
No full textCorrection to: Nature Medicine. Published online 24 April 2023. In the version of this article initially published, the STRATIFY data also included cohort data from the ESTRA consortium, though this was not acknowledged in the author list and the section in Methods on the Stratify dataset. The Methods are now updated, and the author list is amended to combine the STRATIFY and ESTRA consortium names and to include the following authors: Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Hervé Lemaître, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris and Sylvane Desrivières. The STRATIFY and ESTRA consortia are now combined to list Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Gareth J. Barker, Arun L. W. Bokde, Hervé Lemaître, Frauke Nees, Dimitri Papadopoulos Orfanos, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris, Henrik Walter, Robert Whelan, Sylvane Desrivières and Gunter Schumann as members, and the IMAGEN consortium is updated to also include Sylvane Desrivières. Affiliations, author contributions and acknowledgements have been updated to reflect the new authorship, and all changes have been made in the HTML and PDF versions of the article
Risk Factors for Non - Communicable Diseases in A Rural Community: A Retrospective Study
No full textBackground: Rural areas are reporting higher rates of NCDs like cancer, heart disease, diabetes, lung disease, and pulmonary disorders. Poor education, healthcare, and lifestyle choices make these diseases worse among disadvantaged communities. Rural NCD prevention requires recognizing the main risk factors.
Methods: Radha Devi Jageshwari Memorial Medical College & Hospital in Turki, Muzaffarpur, Bihar, conducted this retrospective study from September to November 2024. During the study, 100 NCD patients were included. We used patient records to analyze demographics, lifestyle variables (smoking, alcohol consumption, sedentary behavior, and eating habits), environmental factors (pollution and clean water availability), and comorbidities (hypertension, diabetes, and obesity). SPSS 25.0 and the Chi-square test were used for statistical analysis and categorical data.
Results: The study showed considerable noncommunicable disease risk factors in rural areas. Smoking (45%), drinking (35%), and sedentary activity (50%) were prevalent. Sixty percent of the population ate a high-fat, low-veggie diet. Other environmental factors that increased health risks included pollutant exposure (55%) and lack of clean water (40%). This study also found that high blood pressure (55%), diabetes (40%), and obesity (30%) were more common. Multiple NCDs were more likely in men, older people, and substance abusers.
Conclusion: This study shows that environmental and behavioral risk factors are driving rural NCD incidence. To reduce non-communicable diseases, public health measures must encourage quitting smoking, drinking less, becoming more active, and accessing clean water. Rural towns need early detection and community-based interventions to reduce long-term health costs
Antioxidant potential of Ocimum Sanctum: A review
No full textThe medicinal plant tulsi has therapeutic properties that make it very good for human life. Tulsi is a powerful antioxidant. The ayurvedic herb tulsi is used for its therapeutic effects. It is the cornerstone of India\u27s ayurvedic holistic health system. Every part of the Tulsi plant is utilized to treat a variety of illnesses, such as the human tooth loss treatment Tulsi leaf extract. It is a medicinal plant. Tulsi is also helpful for respiratory infections, bronchitis, and malaria in the skin. (Phimphilai S., Wangcharoen W.) It serves as a tonic for boosting memory and a therapy for alternating fever and diabetes. Compounds that carry out the neutralization reaction are known as antioxidants. Neutralization reactions support cellular balance and lengthen cellular life. The neutralization reaction is maintained by a variety of mechanisms, such as the enzymatic antioxidant system. For instance, vitamin C functions as an antioxidant and is an enzyme that supports the neutralization reaction. Minerals and synthetic substances sustain the neutralizing reaction. Each molecule has the capacity to continue the neutralization process that serves as an antioxidant
Comparative Evaluation of Anesthetic Efficacy of 4 % Articane and 2 % Lidocaine Administering Inferior Alveolar Nerve Block in Mandibular Primary Molar of Children Aged 6-9 Year
No full textBackground: Local anesthetic agents have greatly enhanced dental practice by providing safer and pain-free surgical procedures. Lignocaine is widely considered the gold standard due to its high potency, safety profile, and effectiveness. However, articaine is thought to outperform lignocaine because of its superiortissue and bone diffusion, faster onset, and lower toxicity.
Aim: The purpose of this study is to evaluate and compare the onset time and duration of action, of lignocaine and articaine in pediatric dental patients.
Method: A total of 34 children, aged 6-9years, attending the outpatient clinic of Pediatric and PreventiveDentistry, were randomly divided into two equal groups. One group was administered lignocaine, while the other received articaine for patient undergoing dental procedure involving nerve block
Results: Articaine demonstrated a faster onset of action and a longer duration of anesthesia compared to lignocaine.
Conclusion: Articaine appears to be a more effective local anesthetic agent than lignocaine, particularly in pediatric dental patients
A Potential Source of Omega - 6 and Omega -9 in Capsicum Annum Seed Oil from Jhunjhunu, Rajasthan India
No full textVegetable Capsicum (Capsicum Annum L.) also known as sweet pepper are most consumed spices in the world. It belongs to the Solanaceae family. It derived from Greek word ‘Kapto’ means bite or swallow. The capsicum plant contains a chemical called capsaicin which help to reduce pain & swelling. It also contains important pigments like chlorophyll, anthocyanin and lutein, which has many health benefits. Capsicum peppers are considered to be warm season, day neutral plants, although certain forms show photoperiod reaction. Capsicum annum seeds were an inexpensive and dietary supplement for improving human health. It is used in painful situations like rheumatic diseases, migraine, arthritis and in painful diabetic situations with the development of modern technologies made easy to use of medicinal herbs and determination of all components in chili pepper. The accumulation of heavy metals in seed oil of Capsicum annum were mainly K, Ca, Mg, Fe, Na, Zn, Cuand Mn. Samples of Capsicum annum seed oil cultivated by industrial waste nearby areas of Khetri, Jhunjhunu Rajasthan were collected and on digestion of oil for heavy metals. The following heavy metals were obtained (in mg/100g) Potassium (K) 560.32, Magnesium (Mg) 219.40, Calcium (Ca) 152.33, Iron (Fe) 31.29, Sodium (Na) 14.01, Zinc (Zn) 6.89, Copper (Cu) 5.35, Manganese (Mn) 3.11, by using MP-AES (Microwave Plasma Atomic Emission Spectrometers). Analyses of heavy metal content indicated that the most abundant mineral in Capsicum annum seeds was potassium, followed by Ca, Fe, Zn, Mg, Mn, Na. On GC–FID (Gas Chromatography - Flame Ionization Detection) analysis, the extracted oil mainly composed of poly-unsaturated fatty acid with higher percentage of Linoleic acid (omega-6) (C18:2) 56.88%, Oleic acid (omega-9) (C18:1) 23.57% Palmitic acid (C16:0) 11.99% and Stearic acid (C18:0) 4.72 %. Linolenic acid (C18:3), Arachidic acid (C20:0), Gondoic acid (C20:1), Behenic acid (C22:0) are present in lesser amount. Omega-6 and Omega-9 fatty acids are a kind of polyunsaturated fats. Omega-6 is utilized for lessening the danger of coronary illness, bringing down absolute cholesterol levels, and reducing cancer risk. The dietary benefit of oleic acid (omega-9) in a decent eating routine has been the subject of various investigations with specific highlights on the cardiovascular system
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