3,045 research outputs found
Development of the early axon scaffold in the rostral brain of the small spotted cat shark (<i>Scyliorhinus canicula</i>) embryo
No full textInternational audienceThe cat shark is increasingly used as a model for Chondrichthyes, an evolutionarily important sister group of the bony vertebrates that include teleosts and tetrapods. In the bony vertebrates, the first axon tracts form a highly conserved early axon scaffold. The corresponding structure has not been well characterised in cat shark and will prove a useful model for comparative studies. Using pan-neural markers, the early axon scaffold of the cat shark, Scyliorhinus canicula, was analysed. Like in other vertebrates, the medial longitudinal fascicle was the first axon tract to form from a small cluster of neurones in the ventral brain. Subsequently, additional neuronal clusters and axon tracts emerged which formed an array of longitudinal, transversal, and commissural axons tracts in the Scyliorhinus canicula embryonic brain. The first structures to appear after the medial longitudinal fascicle were the tract of the postoptic commissure, the dorsoventral diencephalic tract, and the descending tract of the mesencephalic nucleus of the trigeminal nerve. These results confirm that the early axon scaffold in the embryonic brain is highly conserved through vertebrate evolution
Colin Humphris
No full text"Colin Humphris 2 Sqdrn. RAAF. 1941 - 1942 Author of - 'Trapped on Timor' (as a result of bombing of Darwin Feb. 19, 1942)".Colin Humphris. 2 Squadron, Royal Australian Air Force 1941 - 1942. Author of - 'Trapped on Timor' (as a result of bombing of Darwin February 19, 1942)
Interview with Colin Wilson, part 4, undated
No full textInterview with Colin Wilson, part 4, features an interview with author Colin Wilson in which he discusses his views regarding society and art, his reclusive nature, and the intellectual and fantastical elements of his works, undated
Interview with Colin Wilson, part 2, undated
No full textInterview with Colin Wilson, part 2, features an interview with author Colin Wilson in which he discusses his views regarding society and art, his reclusive nature, and the intellectual and fantastical elements of his works, undated
Providence College Faculty Author Series 2017-2018: D. Colin Jaundrill
No full textIn this installment of the Faculty Authors Series, D. Colin Jaundrill (History, Providence College) discusses his newest book, Samurai to Soldier: Remaking Military Service in Nineteenth-Century Japan
Providence College Faculty Author Series 2017-2018: D. Colin Jaundrill
No full textIn this installment of the Faculty Authors Series, D. Colin Jaundrill (History, Providence College) discusses his newest book, Samurai to Soldier: Remaking Military Service in Nineteenth-Century Japan
Interview with Colin Jerolmack
No full textColin Jerolmack is an Assistant Professor at New York University
in Sociology and Environmental Studies. He is the author of The
Global Pigeon (forthcoming) and an alumnus of the Robert Wood
Johnson Foundation Scholars in Health Policy Program at Harvard
University
Colin Fraser
No full textPhotograph - Colin Fraser (third from right) in a loaded scow leaving for Fort Chipewyan from Athabasca, Alberta. A group of men are also standing on the pie
Role of the SpG3A protein atlastin-l in axon growth
No full textThe hereditary spastic paraplegias (HSPs) are a group of inherited neurological disorders that are characterized by spastic lower extremity weakness due to a retrograde degradation of corticospinal motor neurons. SPG3A, the gene locus coding for atlastin-l, is the most common cause of early onset HSP. Atlastin-l is a dynamin-like GTPase with a role in formation of the ER network. Implementing knock-down of atlastin-l expression in neurons using interfering RNA reduces the number of neuronal processes and impairs axon formation and elongation during development. Several point mutations found in patients, such as K80A, impair GTPase activity of atlastin-1. In this experiment, I sought to determine if the GTPase activity of atlastin-l is specifically necessary for normal axon growth, in contrast to the whole protein interaction. A knock-in model of the point mutation was created and propogated. It was found that in cultured cortical knock-in neurons when atlastin-l GTPase was limited, the axon lengths ofthe cells were significantly shorter when compared with those in wild-type neurons early in neuronal development. Therefore, the lack of normal axon growth in SPG3A may contribute to its basis of early onset, and may result from a limited GTPase function
Supplemental_Materials – Supplemental material for Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models
No full textSupplemental material, Supplemental_Materials for Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models by Colin K. Franz, Alyssa Puritz, Lewis A. Jordan, Jeffrey Chow, J. Alberto Ortega, Evangelos Kiskinis and Charles J. Heckman in Neurorehabilitation and Neural Repair</p
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