1,382 research outputs found
Chapter Profilo minimo dell’opera di Riccardo Del Punta (1957-2022)
No full textThe author reconstructs and comments on the scientific production of Riccardo del Punta, examining his style, influences, lines of research, and legacy for labour law
Chapter Capability e diritto del lavoro: non solo teoria. Dialogando con Riccardo del Punta
No full textThe paper is a tribute to Riccardo Del Punta, intellectual and jurist. The common thread is the use of Capability Approach in labour law which links the Author to his friend who passed away prematurely. The essay is also an opportunity to revisit the basic foundations of the Capability theory and the recent debate among international labour law scholars with regard to its possible use in the great transformation induced by the double (green and digital) transition
Introduzione alle lingue storiche minoritarie nell’Italia meridionale, in Sardegna e in giro per l’Italia
No full textItaly is a territory rich of different cultures, identities and languages – the latter unfortunately arbitrarily acknowledged as such by the national law 482/1999 (e. g. also Orioles 2003; Toso 2008, the latter recently summarized in Autelli/Caria 2024). In this special issue such language varieties will be describing, shifting from those to be found in the Southern part of Italy and Sardinia to those of the Roms and Sintis spread through the whole Italian peninsula, dealing both with the history of a certain language variety and its linguistic feateures and to the measures untertaken by the state and by the different associoations and research centres to help preserve them
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells
No full textNormally, cell proliferation and death are carefully balanced in higher eukaryotes, but one of the most important regulatory mechanisms, apoptosis, is upset in many malignancies, including hepatocellular-derived ones. Therefore, reinforcing cell death often is mandatory in anticancer therapy. We previously reported that a combination of tumor necrosis factor-alpha (TNF) and cycloheximide (CHX) efficiently kill HTC cells, a rat hepatoma line, in an apoptosis-like mode. Death is actively mediated by the lysosomal compartment, although lysosomal ceramide was previously shown not to be directly implicated in this process. In the present study, we show that TNF/CHX increase lysosomal ceramide that is subsequently converted into sphingosine. Although ceramide accumulation does not significantly alter the acidic compartment, the sphingosine therein generated causes lysosomal membrane permeabilization (LMP) followed by relocation of lysosomal cathepsins to the cytoplasm. TNF/CHX-induced LMP is effectively abrogated by siRNAs targeting acid sphingomyelinase or acid ceramidase, which prevent both LMP and death induced by TNF/CHX. Taken together, our results demonstrate that lysosomal accumulation of ceramide is not detrimental per se, whereas its degradation product sphingosine, which has the capacity to induce LMP, appears responsible for the observed apoptotic-like death.-Ullio, C., J. Casas, U. T. Brunk, G. Sala, G. Fabrias, R. Ghidoni, G. Bonelli, F. M. Baccino, and R. Autelli. Sphingosine mediates TNF alpha-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma. J. Lipid Res. 2012. 53: 1134-1143
Tra geometria e architettura: temi del dottorato di ricerca
No full textQuesto primo volume della Collana degli Strumenti si apre con un importante contributo di Giangiacomo Martines che introduce il tema del rapporto tra architettura e geometria nel mondo classico, portando esempi e inedite testimonianze frutto della grande esperienza dell’Autore, maturata in anni di studio e di contatto diretto con i più grandi monumenti del mondo romano. Alla voce di Martines si accompagnano poi, in un contrappunto ideale, quelle di alcuni giovani studiosi, che in diverse occasioni hanno affrontato il medesimo tema. Carlo Inglese espone alcuni notevoli risultati della sua ricerca sui tracciati di cantiere nell’antichità; Beatrice Angelini illustra recenti scoperte sulla complessa geometria della scala a chiocciola del Bramante, in Vaticano; Daniele Di Marzio ed Erminia Sciacchitano propongono due ricerche bibliografiche, rispettivamente dedicate al disegno e alla geometria della foglia di acanto e al tema generale di questo volume. I saggi sono introdotti da uno scritto di Mario Docci, che illustra le prospettive attuali delle scuole di Dottorato e da altri di Riccardo Migliari, che introducono alle linee di ricerca seguite nella scuola romana.This first volume of the series of instruments opens with an important contribution of Feltrinelli Martines which introduces the theme of the relationship between architecture and geometry in the classical world, by giving examples and unpublished testimonies result of extensive experience of the author, gained through years of study and direct contact with the most important monuments of the Roman world. Martines is accompanied by the voice of then, in a perfect counterpoint, some of those young scholars, who on several occasions have faced the same issue. Charles English exposes some remarkable results of his research on the tracks of the yard in antiquit
Microwave-Assisted, Solid-State Procedure to Covalently Conjugate Hyaluronic Acid to Curcumin: Validation of a Green Synthetic Protocol
No full textA microwave-assisted esterification reaction to prepare hyaluronan-curcumin derivatives by employing a solvent-free process was developed. In particular, a solid-state strategy to react two molecules characterized by totally different solubility profiles was developed. Hyaluronic acid, a highly hydrosoluble polysaccharide, was reacted with hydrophobic and even water-unstable curcumin. Microwave (MW) irradiation was employed to activate the reaction between the two solid compounds through the direct interaction with them and to preserve the integrity of the sensitive curcumin species. This new protocol can be considered efficient, fast, and also eco-friendly, avoiding the employment of toxic organic bases and solvents. A cytotoxicity test suggested that the developed hyaluronan-curcumin conjugate (HA-CUR) could be considered a candidate for its implementation as a new material. In addition, preliminary studies revealed promising anti-inflammatory activity and open future perspectives of further investigation
Hypertextual Library Manifesto Version 1.0
No full textTranslation by Juliana Mazzocchi with the collaboration of Maria Stella Sagaria and Riccardo Ridi. The Italian version was published as Manifesto per la biblioteca ipertestuale. Versione 1.0, Bibliotime X (2007), n. 3, http://www2.spbo.unibo.it/bibliotime/num-x-3/ridi.htm. This manifesto is a bridge between two texts: The Digital Libraries Manifesto, written by AIB Study group on digital libraries (in AIB-WEB since December 2005 at http://www.aib.it/aib/cg/gbdigd05a-e.htm3),and the author\u27s book La biblioteca come ipertesto (The library as hypertext, published by Editrice Bibliografica in October 2007, contents and abstract available at http://www.bibliografica.it/catalogo/ridi-ipertesto.htm). It presents the 25 Theses and the 5 Laws of the hypertextual library
It is foul weather in us all / Riccardo Boglione
No full textRiccardo Boglione sent copies of Shakespeare’s The Tempest to twelve artists living in Europe and America, each copy in the language of the country of residence of the artists, asking them to leave the book outside to the weather for as long as they wanted. The pages from those mistreated volumes reconstruct a Frankensteinian version of the play. In an extension of the metaphor of the tempest, the author gathers a small collection of injured volumes, mimicking Prospero’s book. Simultaneously he produces a version of Shakespeare’s play that shakes notions of authority (who is the real author? The invited artists? The English Bard? Boglione? The translators? Bad weather? Time?) and aesthetics (the ‘work’ of rain, snow, wind, and sun transformed the text’s characteristics, giving it a sculptural dimension that obfuscates its literary one). At stake once again, the perpetual dualisms: objects and words, nature and culture, Old and New World.
Contributors: Paolo Argeri, Luz María Bedoya, Carlos Capelán, Claude Closky, Felipe Cussen, Pablo Echaurren, Belén Gache, Sharon Kivland, Michalis Pichler, Nick Thurston, Pablo Uribe, Luca Viton
Va’ a l’orza! In ricordo dell’amico Riccardo (Dino) Brizzi
No full textIl contributo è dedicato al ricordo del Prof. Riccardo Brizzi (1920-2015), scrittore, grande esperto e studioso della marineria tradizionale dell'Adriatico, autore di importanti libri sull'argomento.The paper is dedicated to the memory of Prof. Riccardo Brizzi (1920-2015), writer, great expert and scholar of the Adriatic maritime tradition and author of important books on the subject
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