1,720,962 research outputs found
PERAN HEPARIN DALAM ANGIOGENESIS, EPITELIALISASI DAN PENYEMBUHAN LUKA BAKAR
No full textHeparin was initially used in small doses as an anticoagulant in the treatment of burns. It turned out that in addition to the anticoagulant, heparin in larger doses can be used as an anti-inflammatory, accelerate angiogenesis (Polykratis, et al., 2004), cell growth and development (Sasisekharan and Venkataraman, 2000) so as to accelerate wound healing (Saliba, 2001; Galvan , 1996). In some countries heparin has been used as a standard therapy treatment of burns (Saliba, 2001). Heparin is one of highest endogenous glycosaminoglycans (GAGs) besides heparan sulfate (HS), keratin sulfate, dermatan sulfate, chondroitin 4-sulfate, chondroitinHS-6-sulfate and hyaluronic acid. heparin are the most acid and are highly sulfated, is the most GAGs widely used in burns as anti-inflammatory, to reduce edema, enhance angiogenesis and accelerate epitelialization (Saliba, 2001). Several studies have revealed the role of heparin in the treatment of burns. Keywords : Heparin, angiogenesis, epitelialization, treatment of burn
CROSS TALK ANTARA SEL PUNCA KANKER DENGAN LINGKUNGAN MIKRO
No full textPengetahuan tentang biologi tumor dan terapi tumor telah berkembang. Namun tumor tetapmerupakan penyakit umum yang mematikan di seluruh dunia. Sel punca kanker adalah bagian dari sel kankerdengan kemampuan sel punca, yang dapat mendorong pertumbuhan tumor, kekambuhan dan tahan terhadapbanyak perawatan antikanker saat ini.Tumor padat dianggap sebagai “organ” yang terdiri dari sel kanker danstroma tumor. Lingkungan mikro tumor membentuk stroma tumor, yang menempati sebagian besar massatumor, termasuk matriks ekstraselular (ECM), sel induk mesenchymal (MSC), sel endotel, sel imun, dan, lebihdari itu, jaringan sitokin dan faktor pertumbuhan. Lingkungan mikro atau nichesekitarsel punca kanker sebagian besarmengatur nasib seluler mereka. Pengetahuan terbaru mengungkapkan bahwa lingkungan mikro mendukung pembaharuandiri sel punca kanker dan sekaligus berfungsi sebagai penghalang fisik terhadap pemberian obat. Lingkungan mikro tumormemainkan peran penting dalam setiap tahap perkembangan tumor.Kata Kunci : Cross Talk, sell punca
PERAN MADU DALAM MENGHAMBAT PERTUMBUHAN BAKTERI PADA LUKA BAKAR
No full textLuka bakar dapat didefinisikan sebagai luka yang disebabkan oleh api, air panas, kontak dengan material panas atau dingin, bahan kimia dan aliran listrik yang melewati jaringan. Luka bakar adalah tempat yang ideal bagi bakteri untuk berkembang biak karena lingkungan nutrisi yang hangat dan lembab.Pengobatan modern untuk mencegah timbulnya infeksi menggunakan silver sulfadiaze (SSD) namun beberapa penelitian menemukan bahwa penggunaan SSD dapat memperpanjang waktu penyembuhan luka. Sebagai pengobatan alternatif, madu dapat digunakan untuk mencegah infeksi tanpa memperpanjang waktu penyembuhan luka.Madu mengandung sejumlah besar karbohidrat, lipid, asam amino, protein, vitamin dan mineral yang memiliki peran penting dalam penyembuhan luka. Madu juga mengandung beberapa senyawa organik, yang telah terindentifikasi antara lain seperti polyphenol, flavonoid, dan glikosida. Mekanisme madu sebagai antibakteri dapat diklasifikasikan secara langsung dan tidak langsung. Mekanisme secara langsung didasarkan pada kemampuan komponen madu untuk membunuh bakteri. Mekanisme secara langsung meliputi mekanisme terbentuknya hidrogen peroksida (H2O2), osmolalitas tinggi, pH rendah, faktor non - peroksida, dan fenol. Mekanisme tidak langsung adalah respon antibakteri dari host yang dirangsang oleh madu terhadap bakteri. Mekanisme antibakteri tidak langsung meliputi limfosit dan produksi antibodi, sitokin dan respon imun, dan nitrit oksida.Kata Kunci : Madu, Luka Bakar, Pertumbuhan Bakter
Kajian Literatur: Pengetahuan dan Perilaku Kesehatan Reproduksi pada Keluhan Flour Albus Patologis
No full textPathological fluor albus is a reproductive problem experienced by women. Reproductive health and sexuality education (KRS) is considered to be one of the solutions to this problem. Comprehensive Sexuality Education (CSE) is an international education program about KRS. This study aims to determine the aspects of knowledge and behavior in reproductive health in pathological fluor albus complaints. This research is a literature review. References were taken from 14 textbooks published in the last 10 years and 34 journals with Scopus Q1 and Q2 indexes and 1 Sinta 2 accredited journal published in the last 5 years. Some articles mention that lack of reproductive health knowledge and poor personal hygiene increase a person's risk of experiencing pathological fluor albus. Providing KRS education and how to clean the genitals properly can improve the quality of personal hygiene which further reduces the risk of pathological fluor albus. Other KRS points in CSE such as how socio-economic, cultural, and health services can have an effect on the quality of one's health are assumed to have an impact on one's health knowledge and behavior. This can increase or decrease a person's risk of experiencing pathological fluor albus. Understanding of pathological fluor albus is influenced by knowledge and behavior in reproductive healt
PENGARUH GEL EKSTRAK KULIT KENTANG(SOLANUM TUBEROSUM L.) TERHADAP LUAS LUKA BAKAR DERAJAT II A
No full textLuka bakar derajat II A adalah luka yang disebabkan oleh kontak langsung atau tidak langsung dengan suhu tinggi seperti api, air panas, listrik, bahan kimia dan radiasi. Pengobatan baku emas memiliki harga yang cukup relatif mahal dan ketersediaan yang kurang. Sedangkan kulit kentang memiliki kandungan glycoalkaloid dan flavonoid sebagai antioksidan sehingga pemberian gel ekstrak kulit kentang diharapkan dapat mengurangi luas luka bakar derajat II A Untuk mengetahui pengaruh gel ekstrak kulit kentang pada luas luka bakar derajat II A True Experimental, Post Test Only Control Group Design. Gel Ekstrak kulit kentang konsentrasi 5%,10% dan 15% diberikan selama 15 hari secara topikal diukur pada hari ke-3 dan ke-10. Analisis data menggunakan One Way ANOVA, Tukey, korelasi pearson, dan regresi linear Gel ekstrak kulit kentang dapat menurunkan luas luka bakar secara bermakna dengan signifikansi 0.00 (ANOVA p=0,05) pada hari ke 3 dan ke 10. Konsentrasi optimal adalah 15%. Nilai korelasi penelitian ini pada hari ke-3 adalah -899 yang menunjukkan hubungan signifikan sangat kuat ,uji regresi menunjukkan pengaruh 80% dan nilai korelasi penelitian ini pada hari ke-10 adalah -921 yang menunjukkan hubungan sangat kuat, uji regresi menunjukkan pengaruh 85%. Gel Ekstrak Kulit Kentang (Solanum Tuberosum L.) dapat menurunkan luas luka bakar derajat II A tikus putih jantan (Rattus novergicus Strain wistar).Kata kunci: Luka bakar derajat II A, Gel Ekstrak kulit kentan
The Effectiveness Of Binahong Leaves And Garlic Tubers Extract Gel For Patients With Burn Injuries
No full textBackground: Burns injuries is a damage of epithelial tissue that caused by heat substance, chemicals, and solar radiation. Binahong leaves and garlic tubers contain several active compounds which have effect as anti-inflammtory and anti-bacterial that can help on the healing process of IIA degree burns. Purpose: To know the effect of binahong leaves and garlic+ tubers exstract gel on the decreasing of IIA degree burns area on white rat (rattus norvegicus strain wistar). Methods: The method describing the design or the design of the research, the research target (population, sample and data sources), techniques and data collection instruments and describes the techniques or data analysis procedures. Results: The result of MANOVA test shows that there is a difference in the size of the burns wound area on 14th day. Post hoc test shows a meaningful different result of 4th group on 14th day, 3rd group on 14th day, and 5th group on 14th day. Pearson test result shows the effect of all extract gel on the 14th day is 0,896 which is classified in significant category.Conclusion: Binahong leaves and garlic tubers exstract gel have effects on IIA degree burns area rattus norvegicus strain wistar
Differences in Complete Blood Results and Nutritional Status of Patients with Cleft Lip and Palate at the CLP Center in University of Muhammadiyah Malang from 2020 to 2022
No full textBackground: Patients with Cleft Lip (CL) and Cleft Lip and Palate (CLP) have difficulties with eating and breastfeeding, which makes them more susceptible to malnutrition (measured using the z-score parameter) and infections. CLP is caused by inappropriate levator palatini muscles and velopharyngeal insufficiency, which can lead to infection, inflammation, and allergies that can affect the immune system. The immune system responds to these components with leukocytes, particularly neutrophils, eosinophils, and lymphocytes.
Objective: To determine the difference in complete blood results and nutritional status between cleft lip and cleft palate at the CLP Centre Faculty of Medicine, University of Muhammadiyah Malang in 2020-2022.
Methods: The research was conducted at the CLP Centre FK UMM using observational methods with a total sample size.
Results: The study found that males had a higher prevalence of CL and CLP. The most common z-score for patients with CL and CLP was below average for those under 24 months old, and above average for those over 35 months old. Extremely low z-scores were more common in CLP patients aged between 24 and 35 months. Patients with CL and CLP were less likely to have anemia, and there was no correlation between the z-score and anemia. Patients below 2 years old with CL and CLP had normal white blood cell counts, while those over 2 years old had higher levels of white blood cells, mainly neutrophils and lymphocytes. Eosinophilia, a condition with high levels of eosinophils, occurred only in patients with CL. Only lymphocytes showed statistically significant hematological values, with a p-value of 0.021 (p<0.05).
Conclusion: It has been found that patients with CL and CLP have a statistically significant difference in their lymphocyte cells. Most cases of nutritional status issues occur in children younger than 24 months with a normal z-score. In contrast, children aged 24-35 months with an inadequate z-score are more likely to have nutritional issues in cases of CLP
The Effect Of Red Dragon Fruit Peel Extract Gel On Rattus Norvegicus Strain Wistar Of Grade Iia Burns Surface Area
No full textBackground: Burns are injuries to body tissues by electric shocks, chemicals, or hot objects. Peel of red dragon fruit contains anti-inflammatory and antibacterial compounds, so it can accelerate the healing of grade IIA burns. Purpose: To prove the effect of red dragon fruit peel extract gel on the surface area of grade IIA burns of Rattus norvegicus strain wistar. Methods: Experimental with post test only control group design. The samples were divided into 5 groups, 1 (Base Gel), 2 (Burnazin plus cream), 3 (Red dragon fruit peel extract gel 10%), 4 (Red dragon fruit peel extract gel 15%), 5 (Red dragon fruit peel extract gel 20%),. The rats\u27 backs were attached by a metal that has been heated in water at 100 ° C for 3 minutes without pressing for 10 seconds. The treatment was carried out for 14 days, then the wound area was measured on the 4th, 7th, and 14th days. The data were analyzed using MANOVA test, Post-hoc Bonferroni and Pearson Correlation. Results: The results of the MANOVA test showed significant differences in the area of the wound on the 14th day. Post-hoc test showed a significant difference occurred in group 5. Pearson Correlation test showed that the effect of red dragon fruit peel extract gel on day 14 was 0.820 which was included in the strong category. Conclusion: There is an effect of red dragon fruit peel extract gel on the area of second degree burns of Rattus norvegicus strain wistar
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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