710 research outputs found
More than meets the eye: exploring Sonic Hedgehog medulloblastoma from a neurodevelopmental perspective
Get PDFCerebellar development is a complex process that requires tight orchestration of various factors to ensure proper cerebellar function. The relatively long time-span for the cerebellum to reach maturity makes the cerebellum vulnerable to developmental dysregulation, which can ultimately manifest in the malignant transformation into medulloblastoma, one of the most frequently diagnosed childhood brain tumors. This thesis aimed at addressing some of the complex interplay of the molecular players during cerebellar development and how they may facilitate tumor formation.In Chapter 1, the development of cerebellar granule cells, the most abundant cell type of the brain, is described based on current literaturereviewed in Chapter 1. The predecessorsir progenitors of these granule cells (e.g., cerebellar granule neuron progenitors or CGNPs) are known to be the cell-of-origin for at least two subtypes of medulloblastoma. In Chapter 2, we studied the dynamic changes in gene expression in murineouse CGNPs during brain development and shed light on the age-specific onset and pathway mutations that are associated with SHH medulloblastoma. In Chapter 3, we explored the role of transcription factor CREB in CGNP development and medulloblastoma therapy, since we had discovered that CREB phosphorylation activity status strongly correlates with patient survival in SHH and Group 3 medulloblastoma. In Chapter 4, we assessed the role contribution genes encoding histone modifier complexes, theof histone modifier KMT2D into medulloblastoma pathogenesis. In the last experimental chapter (Chapter 5), we set out to establish primary pediatric brain tumor cell cultures that faithfully maintain tumor characteristics, which can be employed as models for understanding tumor biology and therapeutic discovery. Finally, we summarized our findings and discussed their implications in Chapter 6
(Motif of blood in the Inna Lisnianskaya’s poetry
No full textInna Lisnianskaya is a Russian poet who has been continuously writing since the fifties andthe author of hundreds outstanding poems. She has built her poetic universe on the basis of certainconcepts. Some of them appear more often than the others and blood is one of them. Abouta hundred of Inna Lisnianskaya’s poems that include the motif of blood was chosen for this work.Their analysis (in accordance to the studies of R. W. Langaker) is to show that the phenomenon ofsubjectification is the basis of the conceptualization process
PROSES POSTING CHARGE TO ROOM DI HOTEL GRAND INNA TUNJUNGAN SURABAYA
Get PDFThe goal achieved in this final preparation is to know the process of posting a
charge to room at the Grand Inna Tunjungan hotel in Surabaya. The author who
also works as a waitress for F&B Service at the Grand Inna Tunjungan Surabaya
hotel makes observations on the process of posting charge to room. The author
concludes that the process of posting a charge to room at the Grand Inna
Tunjungan hotel, Surabaya, is a process of combining costs incurred by guests
(eating and drinking,) whose payment is made when guests check out. Can be
applied to guests who are staying at the hotel who have a deposit to guarantee the
use of hotel facilities that are subject to a fee
That’s not for our kids: The strange death of philosophy and ethics in a low socioeconomic secondary school
Get PDFThis paper is a critical reflection on the teaching of the new Philosophy and Ethics course in a low socioeconomic context in Perth, Western Australia. It charts the successes and failures of the Philosophy and Ethics course, leading to the eventual demise of the subject at the end of 2010. We frame this reflection within Deleuzean notions of geophilosophy to advocate for a Philosophy and Ethics that is informed by nomadic thought as this offers potential for students to become innovative and creative of their selves – the critical freedom we see as potentially transformative for contemporary society. We see the strange death as being influenced by many factors, but that it is best considered as a ‘missed opportunity’ because it has so much potential to be transformative of student subjectivities in schools. We see that this critical reflection could be invaluable in a reconsideration of the scope and focus of the subject often viewed as elitist and impractical
STANDARISASI SEQUENCE OF SERVICE UNTUK MEMPERLANCAR OPERASIONAL KERJA DI PALAPA COFFEE SHOP GRAND INNA TUNJUNGAN SURABAYA
Get PDFThe purpose of this study was to find out how to standardize the sequence of service at Palapa Coffee Shop Grand Inna Tunjungan Surabaya. In this study, the
authors used a qualitative descriptive research type. The author can conclude that the standardization of the sequence of service at The Grand Inna Tunjungan Surabaya is greeting, guest seating, folding napkin laying, giving the menu, beverage and food taking orders, repeat orders, distribute of captain order, beverage serving, dessert suggestion, settle bill, say thank you.
Keywords: sequence of service, service, coffee shop, waiter, waitres
STANDAR OPERASIONAL PROSEDUR SANITASI PERALATAN MAKAN DAN MINUM di PALAPA COFFEE SHOP HOTEL GRAND INNA TUNJUNGAN SURABAYA
Get PDFThe purpose of this final project is to find out how the standard operating procedures for sanitation of eating and drinking equipment at Palapa Coffee Shop Hotel Grand Inna Tunjungan Surabaya. The author observes the operational standards of sanitation equipment for eating and drinking equipment at the palapa coffee shop, Grand Inna Tunjungan Hotel, Surabaya. The author draws the conclusion that with the SOP cleaning the eating and drinking equipment greatly helps employees to carry out the work of washing food and drink equipment in the restaurant Palapa Coffee Shop in accordance with the standards set by the hotel.
Keywords: Standard Operating Procedures, sanitation, cutlery and drinks, restaurants
Promoting 2-3 years old children's sensory development through didactic games
No full textDarba tēma: divu līdz trīs gadus vecu bērnu sensorās attīstības veicināšana didaktiskajās spēlēs. Darba autore: Inna Muravieva Zinātniskā darba vadītāja: Mg.paed., Mg.phil., LU PPMF PN lektore Ērika Lanka Pētījuma mērķis: izpētīt 2-3 gadīgu bērnu sensoro spēju attīstīšanas iespējas didaktiskajās spēlēs. Pētījuma metodes: teorētiskā – pedagoģiski psiholoģiskās literatūras analīze, pedagoģiskās pieredzes analīze. Pētījuma jautājums: Kādas ir didaktisko spēļu iespējas sensoro spēju attīstīšanā 2-3 gadus veciem bērniem? Pirmajā daļā darba autore analizē pagātnes un mūsdienu pedagogu un psihologu atziņas par 2-3 gadus vecu bērnu sensoro spēju būtību un attīstīšanas iespējām. Otrajā nodaļā raksturotas 2-3 gadu vecu bērnu attīstības likumsakarības. Trešajā nodaļā analizēta didaktisko spēļu būtība, klasifikācija, kā arī to izmantošanas iespējas visas analizatoru sistēmas attīstīšanā. Pētījumā daļā aprakstīts praktiskais pētījums par didaktisko spēļu iespējām sensoro spēju attīstīšanā 2-3 gadus veciem bērniem. Atslēgas vārdi: sensorās spējas, maņas, didaktiskās spēles, divu līdz trīs gadus vecu bērnu personības attīstība. Darba apjoms: 55 lpp, 4 pielikumi, 42 literatūras avoti.Research theme: Promoting 2-3 years old children’s sensory development through didactic games. Author: Inna Muravieva Scientific supervisor: Mg.paed., Mg.phil., LU PPMF PN lektore Ērika Lanka Research aim: to explore the possibility of developing sensory abilities of 2-3 years old children through didactic games. Research method: theoretical analysis of psycho-pedagogical literature, the analysis of pedagogical experience. Research question: what are the opportunities of didactic games in realizing 2-3 years old children’s sensory abilities? In the first part the author analyzes the works of old and modern psychologists and educators concerning the essence and development opportunities of 2-3years old children’s sensory abilities. The second part outlines the general regularities of children development. In the third part the author classifies didactic games and analyzes their applicability in sensory system development. The last part includes the practical research of the opportunities of didactic games in realizing 2-3 years old children’s sensory abilities. Key words: sensory abilities, senses, didactic games, 2-3 years old children’s personality development. Research length: 55 pages, 4 appendix, 42 reference
POTENSI EKSTRAK ETANOLIK KULIT BUAH JERUK NIPIS (Citrus aurantiifolia (Cristm.) Swingle) SEBAGAI AGEN KHEMOPREVENTIF MELALUI PENEKANAN EKSPRESI c-Myc DAN PENGHAMBATAN PROLIFERASI PADA SEL PAYUDARA TIKUS GALUR SPRAGUE DAWLEY TERINDUKSI 7,12-DIMETILBENZ[a]ANTRASENA
Get PDFThe using of natural-based medicine is growing rapidly in societies. Besides being cheap and affordable, natural-based medicine is relatively safer than the synthetic drugs. Peel of Citrus aurantifolia (Cristm.) Swingle) is one of the chemopreventive agent which contain flavonoids have potency as anticarcinogenic agent. This study is designed to study the potency of Citrus aurantifolia peel ethanolic extract in proliferation inhibition of Rattus norvegicus mammary cell of Sprague Dawley strain which is induced by 7,12-Dimethylbenz[a]anthracene (DMBA). Rats were divided into five groups consist of DMBA treatment, CMC-Na treatment, extract 1500 mg/kgBW treatment, treatment of DMBA+ extract 750 mg/kgBW and DMBA+ extract 1500 mg/kgBW. At the beginning of the tenth week of the study, breasts was isolated and stored in 10% formalin buffer. Observation of cell proliferation was done by AgNOR method. C-Myc expression observed using immunohistochemistry (IHC). Observation of mammary cell with AgNOR method indicated that the treatment of Citrus aurantifolia peel ethanolic extract can inhibit cell proliferation significantly. Dosage 1500 mg/kgBW gave higher inhibition effect than dosage 750 mg/kgBW. IHC result showed that treatment of Citrus aurantifolia peel ethanolic extract decrease the expression of c-Myc. Dosage 750 mg/kgBW gave lower decreasing effect than dosage 1500 mg/kgBW. Citrus aurantifolia peel ethanolic extract inhibited the proliferation of mammary cell induced DMBA through the inhibition of c-Myc expression in dose dependent phenomena so that it is a potential chemopreventive agent.POTENSI EKSTRAK ETANOLIK KULIT BUAH JERUK NIPIS (Citrus aurantiifolia (Cristm.) Swingle) SEBAGAI AGEN KHEMOPREVENTIF MELALUI PENEKANAN EKSPRESI c-Myc DAN PENGHAMBATAN PROLIFERASI PADA SEL PAYUDARA TIKUS GALUR SPRAGUE DAWLEY TERINDUKSI 7,12-DIMETILBENZ[a]ANTRASENA POTENCY OF CITRUS PEELS (Citrus aurantiifolia (Cristm.) Swingle) ETHANOLIC EXTRACT AS CHEMOPREVENTIVE AGENT THROUGH DOWNREGULATION OF c-Myc EXPRESSION AND INHIBITION OF 7.12-DIMETHYLBENZ[a]ANTRACHENE INDUCED FEMALE SPRAGUE DAWLEY RATS BREAST CELL PROLIFERATION Dewi Pratiwi, Novi Hastuti, Niken Nur W, Inna Armandari, Muthi’ Ikawati,Adam Hermawan dan Edy Meiyanto*)Cancer Chemoprevention Research Center Fakultas Farmasi, Universitas Gadjah Mada ABSTRAK Penggunaan obat berbasis alam saat ini berkembang pesat di semua kalangan masyarakat. Selain karena harga yang lebih terjangkau, obat berbasis alam relatif lebih aman dibandingkan dengan obat sintetik. Kulit jeruk nipis (Citrus aurantiifolia) merupakan salah satu obat berbasis alam mengandung flavonoid yang berpotensi sebagai antikarsinogenesis. Penelitian ini dirancang untuk mengkaji potensi kulit jeruk nipis (C. aurantiifolia) dalam menekan proliferasi sel payudara tikus galur Sprague Dawley yang terinduksi 7,12-Dimetilbenz[a]Antrasena (DMBA). Dalam penelitian ini, tikus dibagi menjadi lima kelompok yakni kelompok perlakuan DMBA, kelompok perlakuan CMC-Na, kelompok perlakuan ekstrak dosis 1500 mg/kgBB , kelompok perlakuan DMBA+ekstrak dosis 750 mg/kgBB dan perlakuan DMBA+ekstrak dosis 1500 mg/kgBB. Pengamatan proliferasi sel payudara dengan metode AgNOR menunjukkan bahwa pemberian ekstrak kulit C. aurantiifolia dapat menekan proliferasi sel secara signifikan. Secara kuantitatif signifikansi yang dihasilkan dosis 1500 mg/kgBB lebih tinggi daripada dosis 750 mg/kgBB. Hasil pengamatan imunohistokimia pada ekspresi c-Myc mendukung data sebelumnya. Pada kelompok dosis 750 terlihat warna coklat pada sitosol yang lebih intens dibanding kelompok dosis 1500. Ekstrak etanolik kulit jeruk nipis dapat menekan proliferasi sel payudara terinduksi DMBA, penekanan proliferasi tersebut meningkat seiring peningkatan dosis sehingga jeruk nipis dapat digunakan sebagai agen khemopreventif
Muammar el Qaddafi and his Green book
No full textDarbam „Muamars Kadafi un viņa Zaļā grāmata”
Darba autore Inna Vasiļevska, darba vadītājs Jānis Ešots.
Darbs sastāv no 41 lapaspuses.
Darbs sastāv no 3 daļām:
1. Muamars Kadafi. Dzīves ceļš.
2. Terorisms, dažādi notikumi un līderu salīdzināšana.
3. Trešās Pasaules teorijas sabiedriskais aspekts.
Pirmā daļa ir veltīta iepazīšanās ar Muamaru Kadafi. Tiek stāstīts par viņa dzīvi un
sasniegumiem.
Otrā daļa ir veltīta terorismam, ar kuru ir saistīta Lībija. Tiek aprakstīti skandalozākie
notikumi, kā arī tiek sniegts populāru Āfrikas līderu salīdzinājums un apkopoti atbilstoši
secinājumi.
Trešā daļa ir veltīta dziļākam ieskatam Kadafi Zaļajā grāmatā. Tiek sīki izskatītas
nodaļas, kas veltītas ģimenei, sievietei un izglītībai.to the work “Muammar el Qaddafi and his Green Book”.
The author of the work is Inna Vasilevska, the supervisor of the work is Janis Eshots.
The work comprises 41 pages.
The work consists of 3 parts:
1. Muammar el Qaddafi. Track of life.
2. Terrorism, different incidents and comparison of leaders.
3. Social aspect of the Third World’s theory.
The first part is devoted to the acquaintance with Muammar el Qaddafi. His life and
achievements are described.
The second part is dedicated to terrorism, which is related to Libya. The most scandalous
incidents are described, as well as the comparison of the most popular African leaders is
performed and the corresponding conclusions are drawn.
The third part is devoted to the deeper insight into Qaddafi’s Green Book. The chapters
concerning the family, women and education issues are profoundly considered
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