186,563 research outputs found
Giovanni Sabadino degli Arienti y la obra Pudica Isabella
No full textEl manuscrito de la obra de Giovanni Sabadino degli Arienti Pudica Isabel se conserva inédito en la Sächsische Landesbibliothek de Dresde. De esta obra el autor realizó dos redacciones. Una, Trattato de Pudicizia, es posterior a 1484, año en que murió su esposa Francesca Bruni, y la dedicó a su cuñada, Colomba Bruni. Años más tarde, escribió otra versión, que dedicó a Isabel la Católica, bajo el título de Pudica Isabel, como el mismo autor declara. Nuestro artículo plantea unas cuestiones sobre la naturaleza de esta obra y las fuentes clásicas de los exempla que usó el autor.-- The manuscript of Giovanni Sabadino degli Arienti Pudica Isabel is kept unpublished in the Sächsische Landesbibliothek in Dresde. The author made two redactions of this work. One Trattato de Pudicizia after 1484, the year his wife Francesca Bruni died, which he dedicated to his sister-in-law, Colomba Bruni. Years later he wrote another version, which he dedicated to Isabella of Castile, under the title of Pudica Isabel, as the author himself declares. Our article raises some questions about the nature of this work and the classical sources of the exempla used by the author
Studio prospettico su pazienti affette da connettivite indifferenziata in gravidanza;confronto con Lupus Eritematoso e Sindrome di Sjogren.
No full textUndifferentiated connective tissue disease (UCTD) is a term used to identify a group of patient that while presenting common symptoms of systemic connective disease does not fulfil the criteria for a definite connective tissues disease. Arthralgias, Raynaud, mild fever and anti nuclear antibodies common features in UCTD patients.
We have prospectively followed 50 pregnancies in 43 women with UCTD, 142 pregnancies in 111 women with SLE and 35 pregnancies in 26 women with primary Sjögren’s Syndrome.
In UCTD women the mean gestational age at delivery was 38.6 weeks, the prevalence of pregnancy loss 2%, preterm birth 2%, cesarean sections 30.5%, Premature Rupture of Membrane (PROM) 0%, preeclampsia 0%, Intra Uterine Growth Retardation (IUGR) 8.2% and newborns Small for Gestational Age (SGA) 12.2%; average weight at birth was 3062.5 g.
In SLE group the mean gestational age at delivery was 37.8 weeks, prevalence of pregnancy loss 14.7% (p < 0.005 vs UCTD), preterm birth 22.5%, cesarean sections 61.7%, PROM 8%, preeclampsia 4.2%, IUGR 1.7% and SGA 12.1%; average weight at birth was 2876.8 g (p < 0.05 vs UCTD).
In women with Sjögren syndrome the mean gestational age at delivery was 38.5 weeks, prevalence of pregnancy loss 8.6%, preterm birth 13.9%, cesarean sections 29.4%, PROM 3.1%, preeclampsia 0%, IUGR 3.1% and SGA 6.3%.
Conclusion: the general outcome of UCTD pregnancies is similar to that observed in women with primary Sjögren’s syndrome, and better than in SLE women. No patients evolved into a definite CTD, nor required an important modification of therapy during and after pregnancy. The general outcome of these pregnancies is now excellent, if prospectively followed by multidisciplinary teams with great experience in this field
A ECONOMIA POLÍTICA DOS PETRODÓLARES
No full textTCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Relações Internacionais.A região do Oriente Médio é conhecida por sua instabilidade política e social, recebendo extensa cobertura midiática sempre que há conflitos na área. Um dos motivos pela preocupação internacional com as dinâmicas daqueles países está relacionado à abundância de petróleo e gás natural que a região possui. Os Estados do Oriente Médio fornecem um combustível importante para os projetos de desenvolvimento e industrialização de países espalhados por todo o globo. Assim, a presente pesquisa busca observar os períodos históricos de aumento do preço do barril do petróleo, mais especificamente as décadas de 1970 e 2000, com um olhar sobre o comportamento dos países do Oriente Médio exportadores deste insumo. Como tais Estados fizeram uso dos novos excedentes comerciais gerados? Quais foram as causas envolvidas nos diferentes tipos de reciclagem dos petrodólares? Diversos estudos analisam os fenômenos de reciclagem dos petrodólares nesses dois períodos, contudo esse trabalho busca fazê-lo de forma comparada, através da ótica da Economia Política Internacional e de todo o contexto político-econômico por trás dos diferentes períodos estudados. O resultado desta pesquisa revela a importância da análise histórica tanto política quanto econômica da região, das mudanças no sistema financeiro internacional nos anos que dividem os dois períodos estudados e também na importância das políticas sendo adotadas por alguns Estados da região, uma vez que essas tendem a difundir-se para os demais paíse
O CAPITAL INTERNACIONAL DENTRO DO SISTEMA INTERNACIONAL: A INFLUÊNCIA DAS AGÊNCIAS DE RATING NAS POLÍTICAS ECONÔMICAS DO BRASIL
No full textTCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Relações Internacionais.As alterações provindas da globalização levaram a uma nova dinâmica do sistema internacional. No que diz respeito à nova ordem econômica que surge a partir da globalização, a desregulamentação e a liberalização são os elementos fundamentais do novo regime financeiro internacional. Esse novo regime financeiro permitiu a ascensão e consolidação dos investidores institucionais, do processo de securitização e do surgimento dos derivativos. Ademais, o sistema vigente torna-se muito especulativo e volátil com grande mobilidade de capitais. Portanto, neste contexto de incertezas e assimetria de informações ganham destaque as agências de rating. O estudo deste trabalho é baseado no grau de influência política que estas agências podem sofrer dos governos/empresas na classificação dos títulos; assim como, analisar a influência das agências de rating nas políticas domésticas. O objeto de análise é o Brasil, principalmente, a partir da estabilidade econômica de 1994, passando pela transição do governo Fernando Henrique Cardoso para o governo Lula, e os anos subsequentes até o momento atual
A systematic review that is ``rapid'' and ``living'': A specific answer to the COVID-19 pandemic
No full textObjective: This study aims to describe “rapid living” systematic reviews, an innovative methodological design used to systematically synthesize emerging evidence in the field of rehabilitation during the COVID-19 pandemic. Study Design and Setting: A methodological paper, with a formative approach to rapid living systematic reviews. Results: Based on our experience, we propose the following definition of rapid living SR: ``A dynamic method of knowledge synthesis that allows for the constant updating of new emerging evidence and refinement of its methodological quality.'' This method has the benefit of accelerating the conduct of traditional systematic reviews and allows for a synergistic adaptation of methodology based on the quality of the evidence with a flexibility to update results, methods and collaborations. Conclusion: Our proposed methodology has been helpful to synthesize the rapidly evolving evidence in the field of rehabilitation during the pandemic. Similarly, it may be useful when a rapid answer is urgently needed to make informed decisions. The COVID-19 disease has shown that modern medical science has the ability to produce new knowledge at a rate never seen before. Therefore, our proposed rapid living systematic reviews provide the scientific community with a method to rapidly synthesize evidence when facing health emergencies
Phosphorylation pattern of liver proteins during the early stages of the acute-phase response
No full textLiver preparations from turpentine-treated rats show an increased capacity to autophosphorylate a protein of 32.5 kDa (p 32.5): both the kinase and the substrate protein are strongly bound to the membrane fraction, but the protein is released to the cytosol after phosphorylation, which occurs exclusively in serine residues. No known second messenger-dependent protein kinase seems to be responsible for the reaction. Phosphorylation of p 32.5 could be an early post-receptorial event after turpentine-treatment possibly caused by cytokines and involved in the pathogenesis of further events of the acute-phase response
Biochemicals events in the liver cell during the early stages of the acute-phase response
No full textState and activity of protein kinase C in postischemic reperfused liver
No full textWe have studied the activity and the phorbol-binding capacity of protein kinase C (PKC) in subcellular fractions, as well as the relative amount of the enzyme protein in rat livers reperfused after severe nonnecrogenic ischemia. Ischemia causes a significant decrease in PKC phosphotransferase activity in both membranes and cytosol which lasts long after the reestablishment of the blood flow. The phorbol-binding capacity of the membrane fraction shows the same behavior. The amount of PKC protein decreases during ischemia (-25%) but returns to normal after reperfusion more promptly than activity and binding capacity, suggesting that PKC resynthesized in postischemic livers is either functionally defective or incapacitated by unsuitable conditions of the environment. We have also measured the contents of some lipids that may influence PKC activity in the cell. During ischemia and reperfusion there is a significant increase in the content of 1,2-diacylglycerol (DAG), which is the physiological activator of PKC, but under the conditions occurring in the ischemic/postischemic livers DAG apparently cannot bind to the enzyme and fulfill its function. Total phospholipids, phosphatidylcholine, and phosphatidylethanolamine, which significantly decrease at 60 min of ischemia, return to normal levels 1 hr after reperfusion
P 165 - Changes in gait kinematic parameters after rehabilitation in total knee arthroplasty subjects: A prospective observational pilot study
No full textTotal knee arthroplasty is a common intervention and it is usually followed by a rehabilitation period, to recover physical functioning. The aim of this study is to evaluate the changes of gait kinematic parameters due to rehabilitation after total knee arthroplasty. After inclusion and exclusion criteria the subjects were evaluated with Barthel Index (BI), International Knee Society Score (IKSS), Knee Flexion (KF), NRS and Instrumental Gait Analysis (GA), at admission (T0) and discharge (T1). Many parameters show a significant improvement during rehabilitation IKSS, BI, KF (P < 0.05), GA parameters were close to be significant (P = 0.05) and NRS was not significant (P > 0.05), all the significant evaluation scales and gait analysis parameters had a significant clinical effect size (Cohen's d > 0.8). The rehabilitation process seems to be effective in improving gait parameters and knee functionin
Rat liver eicosanoid synthesis during turpentine-induced inflammation
No full textSubcellular liver fractions from rats receiving a subcutaneous injection of turpentine, which causes a local inflammation, show an increased synthesis of Prostaglandin E2 and Prostaglandin F2 alpha which reaches a peak 90 minutes and 3 hours after treatment, respectively. Stimulation of phospholipase A2 activity of liver cell preparations seems to be responsible for the supply of arachidonic acid necessary to feed PG synthesis: this stimulation is accompanied by unchanged levels of diacylglycerol lipase, diacylglycerol kinase and protein kinase C activities and by an unchanged content of diacylglycerol in the liver tissue. This picture does not favour the hypothesis of an involvement of phospholipase C in the early stages after turpentine treatment. Determinations of GTP-ase activity in plasma membrane-rich liver preparations give ambiguous results, which do not allow any conclusion on the possible role of G-proteins in phospholipase A2 activation
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