50,813 research outputs found
Long-Term Clinical Outcome in Systemic Lupus Erythematosus Patients Followed for More Than 20 Years: The Milan Systemic Lupus Erythematosus Consortium (SMiLE) Cohort
No full textTackling active disease to prevent damage accrual constitutes a major goal in the management of patients with systemic lupus erythematosus (SLE). Patients with early onset disease or in the early phase of the disease course are at increased risk of developing severe manifestations and subsequent damage accrual, while less is known about the course of the disease in the long term. To address this issue, we performed a multicentre retrospective observational study focused on patients living with SLE for at least 20 years and determined their disease status at 15 and 20 years after onset and at their last clinical evaluation. Disease activity was measured through the British Isles Lupus Assessment Group (BILAG) tool and late flares were defined as worsening in one or more BILAG domains after 20 years of disease. Remission was classified according to attainment of lupus lowdisease-activity state (LLDAS) criteria or the Definitions Of Remission In SLE (DORIS) parameters. Damage was quantitated through the Systemic Lupus Erythematosus International Collaborating Clinics/American College of Rheumatology damage index (SLICC/ACR-DI). LLAS/DORIS remission prevalence steadily increased over time. In total, 84 patients had a late flare and 88 had late damage accrual. Lack of LLDAS/DORIS remission status at the 20 year timepoint (p = 0.0026 and p = 0.0337, respectively), prednisone dose ≥ 7.5 mg (p = 9.17 × 10−5 ) or active serology (either dsDNA binding, low complement or both; p = 0.001) were all associated with increased late flare risk. Late flares, in turn, heralded the development of late damage (p = 2.7 × 10−5 ). These data suggest that patients with longstanding SLE are frequently in remission but still at risk of disease flares and eventual damage accrual, suggesting the need for tailored monitoring and therapeutic approaches aiming at effective immunomodulation besides immunosuppression, at least by means of steroids
COVID-19 in systemic lupus erythematosus : data from a survey on 417 patients
No full textBackground: Systemic lupus erythematosus (SLE) is a chronic disease characterised by autoimmunity and increased susceptibility to infections. COVID-19 is a systemic viral disease currently spreading as a pandemic. Little is known about the impact of COVID-19 in patients with SLE. Objective: to acquire information on the impact of COVID-19 in SLE. Methods: A 26-item anonymous questionnaire investigating demographics, SLE clinical features, COVID-19 diagnoses and changes in treatments and daily habits was administered to patients with SLE from three referral centres through www.surveymonkey.com over 10 days. Data from the survey were compared to those from published estimates about the general population. Results: Four-hundred-seventeen patients responded to the survey. More than 60% of subjects complained of symptoms that are also associated to COVID-19. Fourteen COVID-19 diagnoses (five confirmed by polymerase chain reaction) were reported, in contrast to a 0.73% prevalence of confirmed cases in Lombardy. One hospitalisation was reported. Fever, anosmia, dry cough, a self-reported history of neuropsychiatric SLE and a recent contact with confirmed COVID-19 cases were more strongly associated with COVID-19, as were symptoms and lower compliance to behavioural preventive measures in patients’ contacts. No protective effect was seen in subjects on hydroxychloroquine. Conclusion: COVID-19 morbidity might only moderately be increased in most patients with SLE, although limited information can be inferred on more severe cases. Hydroxychloroquine apparently seems not to confer protection to infection per se, although other beneficial roles cannot be excluded. Containment policies and behavioural preventive measures could have a major role in limiting the impact of COVID-19 in patients with SLE
Differential Acquisition of m-Sequences using Recursive Soft Sequential Estimation
No full textIn this contribution a novel sequential estimation method is proposed for the acquisition of -sequences. This sequential estimation method exploits the principle of iterative soft-in-soft-out (SISO) decoding for enhancing the acquisition performance, and that of differential pre-processing for the sake of achieving an enhanced acquisition performance, when communicating over various communication environments. Hence the advocated acquisition arrangement is referred to as the Differential Recursive Soft Sequential Estimation (DRSSE) acquisition scheme. The DRSSE acquisition scheme exhibits a low complexity, which is similar to that of an -sequence generator, while achieving an acquisition time that is linearly dependent on the number of stages in the -sequence generator. A low acquisition time is achieved with the advent of the property that the proposed DRSSE scheme is capable of determining the real-time reliabilities associated with the decision concerning a set of, say , consecutive chips. This set of consecutive chips constitutes the sufficient initial condition for enabling the local -sequence generator to produce a synchronized local despreading -sequence replica. Owing to these attractive characteristics, the DRSSE acquisition scheme constitutes a promising initial synchronization scheme for acquisition of long -sequences, when communicating over various propagation environments
∑_(l+m=k,l,m≥0) ((α+l-1)¦l) ((β+m-1)¦m)=((α+β+k-1)¦k) and its application to negative binomial distribution
Get PDFWe prove here the following equation: ∑_(l+m=k,l,m≥0) ((α+l-1)¦l) ((β+m-1)¦m)=((α+β+k-1)¦k) and give its application to prove the reproductive property of the negative binomial distribution.
These finite sum equation involving binomial coefficients and proof of the reproductive property are not known as far as the author knows.論文(Article)departmental bulletin pape
De Maiestate / Praeside M. Jacobo Thomasio, Moralis Philosoph. P. P., publice disputabit Johannes Dunte, R. L. Author & Respon: ad diem 9. Septembr. H L. Q. C.
No full textDE MAIESTATE / PRAESIDE M. JACOBO THOMASIO, MORALIS PHILOSOPH. P. P., PUBLICE DISPUTABIT JOHANNES DUNTE, R. L. AUTHOR & RESPON: AD DIEM 9. SEPTEMBR. H L. Q. C.
De Maiestate / Praeside M. Jacobo Thomasio, Moralis Philosoph. P. P., publice disputabit Johannes Dunte, R. L. Author & Respon: ad diem 9. Septembr. H L. Q. C. (1)
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Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Informetrics on M. N. Srinivas
Get PDFM. N. Srinivas, the well known sociologist is widely recognised as architect of modern Indian sociology and social anthropology. His publications have been analysed by year, domain, authorship pattern, channels of communication used. Keywords, etc. The results indicate that the papers published by him are of a nature that qualify him to be a 'role model' for the younger generations to emulate.
By the end of 1995, Srinivas had to his credit 144 papers which, included 33 broad papers in sociology and anthropology; 18 papers in social change; 28 papers in village studies; 12 papers on religion; 17 papers on caste and 36 papers of general popular interest. The periods 1958-61 and 1974-77, when Srinivas was 38-41 and 58-61 years old. were his most productive periods with highest publication activity
The stability of IQ in people with low intellectual ability: an analysis of the literature
Get PDFA meta-analysis of the stability of low IQ (IQ 80) was performed on IQ tests that have been
commonly used—tests that were derived by D. Wechsler (1949, 1955, 1974, 1981, 1991, 1997)
and those based on the Binet scales (L. M. Terman, 1960; L. M. Terman & Merrill, 1972). Weighted-
mean stability coefficients of .77 and .78 were found for Verbal IQ (V IQ) and Performance IQ
(P IQ) on the Wechsler tests and .82 for Full-Scale IQ (FS IQ) on both Wechsler and Binet tests,
for a mean test–retest interval of 2.8 years. Although the majority of FS IQs changed by less than
6 points, 14% changed by 10 points or more. The author suggests that the results of IQ assessment
should be treated with more caution than previously thought
Downlink Space–Time Spreading Using Interference Rejection Codes
No full textIn this paper, the authors will investigate the performance of a loosely synchronized (LS) code-based space–time spreading (STS) scheme in comparison to that of classic Walsh code and pseudonoise code-based STS when communicating over dispersive Nakagami-m multipath channels. Closed-form formulas are derived for characterizing the bit-error-rate performance as a function of the number of resolvable paths L and the number of users K. Our numerical results suggest that the employment of LS code-based STS scheme is beneficial in a low-user-load and low-dispersion channel scenario, where a near-single-user performance can be achieved without a multiuser detector. Index Terms—Code-division multiple access (CDMA), Gaussian approximation, interference-free window (IFW), large area synchronized (LAS) codes, loosely synchronized (LS) codes, Nakagami-m fading
L-invariants for cohomological representations of PGL(2) over arbitrary number fields
Get PDFGehrmann L, Pati MR. L-invariants for cohomological representations of PGL(2) over arbitrary number fields. Forum of Mathematics, Sigma. 2024;12: e71.**Abstract**
Let
be a cuspidal, cohomological automorphic representation of an inner form
G
of
over a number field
F
of arbitrary signature. Further, let
be a prime of
F
such that
G
is split at
and the local component
of
at
is the Steinberg representation. Assuming that the representation is noncritical at
, we construct automorphic
-invariants for the representation
. If the number field
F
is totally real, we show that these automorphic
-invariants agree with the Fontaine–Mazur
-invariant of the associated
p
-adic Galois representation. This generalizes a recent result of Spieß respectively Rosso and the first named author from the case of parallel weight
to arbitrary cohomological weights.
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