1,720,972 research outputs found
Supplementary_file_1 – Supplemental material for Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis
No full textSupplemental material, Supplementary_file_1 for Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis by Angelo Zinellu, Panagiotis Paliogiannis, Maria Franca Usai, Ciriaco Carru and Arduino A. Mangoni in Therapeutic Advances in Chronic Disease</p
Supp_figure – Supplemental material for Real-world incidence of patient-reported dyspnoea with ticagrelor
No full textSupplemental material, Supp_figure for Real-world incidence of patient-reported dyspnoea with ticagrelor by Adaire E. Prosser, Jessica L. Dawson, KethLyn Koo, Karen M. O’Kane, Michael B. Ward, Richard J. Woodman, Arduino A. Mangoni and Cameron J. Phillips in Therapeutic Advances in Drug Safety</p
Supplemental_Material – Supplemental material for A pilot cohort study of deprescribing for nursing home patients acutely admitted to hospital
No full textSupplemental material, Supplemental_Material for A pilot cohort study of deprescribing for nursing home patients acutely admitted to hospital by Patrick Russell, Sara Laubscher, Gregory W. Roberts, Arduino A. Mangoni, Cameron McDonald, Ivanka Hendrix, Udul Hewage, Dirk Hofmann, Sophie Michell, Lauren Taeuber, Richard J. Woodman, Sepehr Shakib, Gregory B. Crawford, John Maddison and Campbell Thompson in Therapeutic Advances in Drug Safety</p
Transsulfuration pathway thiols and methylated arginines: the hunter community study
No full textBackground: Serum homocysteine, when studied singly, has been reported to be positively associated both with the
endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine
dimethylaminohydrolase (DDAH) activity] and with symmetric dimethylarginine (SDMA). We investigated combined
associations between transsulfuration pathway thiols, including homocysteine, and serum ADMA and SDMA concentrations at population level.
Methods: Data on clinical and demographic characteristics, medication exposure, C-reactive protein, serum ADMA and SDMA (LC-MS/MS), and thiols (homocysteine, cysteine, taurine, glutamylcysteine, total glutathione, and cysteinylglycine; capillary electrophoresis) were collected from a sample of the Hunter Community Study on human ageing [n = 498, median age (IQR) = 64 (60–70) years].
Results: Regression analysis showed that: a) age (P = 0.001), gender (P = 0.03), lower estimated glomerular filtration rate (eGFR, P = 0.08), body mass index (P = 0.008), treatment with beta-blockers (P = 0.03), homocysteine (P = 0.02), and glutamylcysteine (P = 0.003) were independently associated with higher ADMA concentrations; and b) age (P = 0.001), absence of diabetes (P = 0.001), lower body mass index (P = 0.01), lower eGFR (P<0.001), cysteine (P = 0.007), and glutamylcysteine (P<0.001) were independently associated with higher SDMA concentrations. No significant associations were observed between methylated arginines and either glutathione or taurine concentrations.
Conclusions: After adjusting for clinical, demographic, biochemical, and pharmacological confounders the combined assessment of transsulfuration pathway thiols shows that glutamylcysteine has the strongest and positive independent associations with ADMA and SDMA. Whether this reflects a direct effect of glutamylcysteine on DDAH activity (for ADMA) and/or cationic amino acid transport requires further investigations.</br
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The Concomitant Use of Diuretics, Non-Steroidal Anti-Inflammatory Drugs, and Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers (Triple Whammy), Extreme Heat, and In-Hospital Acute Kidney Injury in Older Medical Patients
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Forest plot depicting the relative risk of MI in diabetic RA patients versus those without T2D using random effect model.
No full text<p>Forest plot depicting the relative risk of MI in diabetic RA patients versus those without T2D using random effect model.</p
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