105 research outputs found
Pleural Aspergillosis in an otherwise healthy individual
No full textPleural Aspergillosis is a rare entity, with most of the cases occurring on a background of lung disease or surgery. We report a case of a 16-year-old boy who developed pleural Aspergillosis in the absence of any obvious pre-disposing factors. Patient presented with fever, dry cough and left sided chest discomfort of 6 weeks duration. A chest radiograph revealed features of the left pyopneumothorax. Despite being started on presumptive antituberculous treatment and intercostal drainage his symptoms failed to resolve. The sputum and pus were then subjected to fungal smears and culture, which indicated growth of Aspergillus fumigatus. We report this case in view of the extreme rarity of pleural Aspergillosis occurring in a young healthy individual with no evidence of prior lung pathology. Furthermore, the source of infection was traced back to a very unusual possible focus - a decayed tooth infected with A. fumigatus, thus making the case even more interesting
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
No full textThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
Scientometric portrait of Nobel laureate Leland H. Hartwell
No full textLeland H. Hartwell was honoured with the Nobel Prize in Physiology or Medicine (2001) at his 62 years age and at 41 years of research publishing career. The first contribution of the author was in 1961 at the age of 22. The number of his contributions in a year peaked in 1997 when it touched 8. He had 108 publications during 1961 – 2001 in domains: Molecular Biology of Cell Cycle Regulation (43), Genetics of Cell Division (48), Genomic Re-arrangement and DNA Repair (9), Molecular Genetics of Yeast Cell Fission (5), and Drug Target Interaction (3) which were analysed for authorship pattern with his 101 collaborators. Most active researchers having number of publications with Leland H. Hartwell were : Weinert, T. A. (10), Garvik, B. M. (8), McLaughlin, C. S. (8), Jenness, D. D. (5). His productivity coefficient was 0.76 which clearly indicates that his productivity increased after 50 percentile age. Highest collaboration coefficient (1) for Leland H. Hartwell was found during 1963-1965, 1968-1969, 1977, 1981-1983, 1985-1990, 1996 and 1998-2001. Journals have been the most preferred channel of communication where, as many as 96 papers out of 108 have been published. The core journals publishing his papers were: Cell (14), Genetics (12), Mol. Cell Biol. (8), J. Bactariol. (7), J. Cell Biol. ( 7), Science (7) J. Mol. Biol.(6), Exp. Cell Res. (5), and Proc. Nat. Acad. Sci.(5). Publication density is 2.63 and Publication concentration is 14.63. Most prolific keywords in titles of publications were: Saccharomyces cerevisiae , Yeast , Cell division cycle , RAD9, DNA Damage , Genes , Cell cycle, Genetic control , Check point (s) , Cell division , Mutant of Yeast
Assessment of Nutritional Status, Initial Haematological Parameters and Sociodemographic Factors in New Sputum Positive Pulmonary Tuberculosis Patients and Their Correlation with Treatment Outcome
No full text<p><strong>Purpose:</strong> The purpose of the study was to find out the correlation between the initial nutritional status, initial haematological parameters, and sociodemographic factors and the treatment outcome at the end of 6 months of anti-tubercular therapy of the patients enrolled in the study. </p>
<p><strong>Materials & Methods:</strong> 100 new sputum positive Pulmonary TB patients were enrolled and the initial nutritional status of the patients was assessed with height, weight and BMI. Other anthropometric indices such as Waist Hip ratio, Mid Upper Arm Circumference, Waist Height ratio were also noted down to find out the nutritional status of the patients. The baseline haematological parameters such as Serum Haemoglobin, Total Leukocyte count, Platelet count, Total Serum Protein, Total Serum Bilirubin, ALT, AST, Blood Urea, Serum Creatinine, Random Blood Sugar were also determined. All the patients who were enrolled in the study were provided with Anti Tubercular Therapy for Drug Sensitive TB for a period of 6 months, as per the guidelines for Drug Sensitive TB under RNTCP. At the end of 6 months of treatment, the treatment outcome of the patients was found out. The patients who were cured were grouped into positive treatment outcome group. The patients who failed the regimen, who were lost to follow up and died during the course of treatment, were grouped into negative treatment outcome group. A few patients who got diagnosed with drug resistant TB during the study were grouped into treatment regimen changed group. None of the patients enrolled in the study developed any serious adverse effects during the study that required them to modify their ATT regimen. </p>
<p><strong>Result:</strong> In this study, out of 100 new sputum positive pulmonary TB patients, 60% patients were male with a mean age of 42.92± 3.46 years. Out of the total number of patients, 49% patients had a positive treatment outcome (cured), 5% patients succumbed to the infection, 9% patients were lost to follow up, 17% patients failed the treatment and 20% patients had to change their treatment regimen during the course of the therapy. Age and gender of the patients were found to have no significant association with the treatment outcome. 73.5% patients with their body weight above 60 kg had a positive treatment outcome. This corroborates the fact that by improving the nutritional status of the patient, the treatment outcome can improve. The mean BMI of the patients was 20.2±3.7 and 31% patients were underweight. Among the patients who were underweight, 64.5% patients had a negative treatment outcome. This substantiates the fact that underweight TB patients are more prone to have a negative treatment outcome than patients who have a normal BMI. 74.2% of the patients who had a low waist hip ratio ended up having a negative treatment outcome. This further confirms that nutritional status is a determining factor in the treatment outcome of Pulmonary TB patients. The MUAC of the patients were measured and 74.2% patients who were malnourished had a negative treatment outcome. Also, 49 patients who had a normal MUAC ended up having a positive treatment outcome. This establishes that improving the nutritional status of the patients can improve the treatment outcome. The waist height ratio of the patients was also measured and 74.2% of the patients who were underweight, ended up having a negative treatment outcome. Also, 55.1% of the patients who had a healthy weight had a positive treatment outcome. This also favours the fact that proper nutrition can improve the treatment outcome of the patients. 77.4% of the patients who belonged to the lower socioeconomic class, as determined by the modified Kuppuswamy scale had a negative treatment outcome. Also, 55% of the patients who had their treatment regimen changed also belonged to lower socioeconomic class. These points out that backwardness in social and economic conditions of the patients can result in negative treatment outcome. 87.1% of the patients who were anaemic had a negative treatment outcome. This suggests the strong correlation between anaemia and poor treatment outcomes in pulmonary TB patients. Correction of anaemia has to be a priority in pulmonary TB patients undergoing treatment. 87% of the patients with low protein levels had a negative treatment outcome. This points out the fact that hypoproteinemia has to be addressed alongside ATT for improving the treatment outcome in Pulmonary TB patients.</p>
<p> <strong>Conclusion:</strong> Pulmonary TB is associated with significant nutritional abnormalities. The findings of the study point to the fact that apart from BMI as the sole parameter for assessing the nutritional status in TB patients, there is a need to consider other anthropometric indices such as waist hip ratio, mid upper arm circumference, waist height ratio that can significantly correlate with the treatment outcome.</p>
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<p> </p><p><strong>Purpose:</strong> The purpose of the study was to find out the correlation between the initial nutritional status, initial haematological parameters, and sociodemographic factors and the treatment outcome at the end of 6 months of anti-tubercular therapy of the patients enrolled in the study. <strong>Materials & Methods:</strong> 100 new sputum positive Pulmonary TB patients were enrolled and the initial nutritional status of the patients was assessed with height, weight and BMI. Other anthropometric indices such as Waist Hip ratio, Mid Upper Arm Circumference, Waist Height ratio were also noted down to find out the nutritional status of the patients. The baseline haematological parameters such as Serum Haemoglobin, Total Leukocyte count, Platelet count, Total Serum Protein, Total Serum Bilirubin, ALT, AST, Blood Urea, Serum Creatinine, Random Blood Sugar were also determined. All the patients who were enrolled in the study were provided with Anti Tubercular Therapy for Drug Sensitive TB for a period of 6 months, as per the guidelines for Drug Sensitive TB under RNTCP. At the end of 6 months of treatment, the treatment outcome of the patients was found out. The patients who were cured were grouped into positive treatment outcome group. The patients who failed the regimen, who were lost to follow up and died during the course of treatment, were grouped into negative treatment outcome group. A few patients who got diagnosed with drug resistant TB during the study were grouped into treatment regimen changed group. None of the patients enrolled in the study developed any serious adverse effects during the study that required them to modify their ATT regimen. <strong>Result:</strong> In this study, out of 100 new sputum positive pulmonary TB patients, 60% patients were male with a mean age of 42.92± 3.46 years. Out of the total number of patients, 49% patients had a positive treatment outcome (cured), 5% patients succumbed to the infection, 9% patients were lost to follow up, 17% patients failed the treatment and 20% patients had to change their treatment regimen during the course of the therapy. Age and gender of the patients were found to have no significant association with the treatment outcome. 73.5% patients with their body weight above 60 kg had a positive treatment outcome. This corroborates the fact that by improving the nutritional status of the patient, the treatment outcome can improve. The mean BMI of the patients was 20.2±3.7 and 31% patients were underweight. Among the patients who were underweight, 64.5% patients had a negative treatment outcome. This substantiates the fact that underweight TB patients are more prone to have a negative treatment outcome than patients who have a normal BMI. 74.2% of the patients who had a low waist hip ratio ended up having a negative treatment outcome. This further confirms that nutritional status is a determining factor in the treatment outcome of Pulmonary TB patients. The MUAC of the patients were measured and 74.2% patients who were malnourished had a negative treatment outcome. Also, 49 patients who had a normal MUAC ended up having a positive treatment outcome. This establishes that improving the nutritional status of the patients can improve the treatment outcome. The waist height ratio of the patients was also measured and 74.2% of the patients who were underweight, ended up having a negative treatment outcome. Also, 55.1% of the patients who had a healthy weight had a positive treatment outcome. This also favours the fact that proper nutrition can improve the treatment outcome of the patients. 77.4% of the patients who belonged to the lower socioeconomic class, as determined by the modified Kuppuswamy scale had a negative treatment outcome. Also, 55% of the patients who had their treatment regimen changed also belonged to lower socioeconomic class. These points out that backwardness in social and economic conditions of the patients can result in negative treatment outcome. 87.1% of the patients who were anaemic had a negative treatment outcome. This suggests the strong correlation between anaemia and poor treatment outcomes in pulmonary TB patients. Correction of anaemia has to be a priority in pulmonary TB patients undergoing treatment. 87% of the patients with low protein levels had a negative treatment outcome. This points out the fact that hypoproteinemia has to be addressed alongside ATT for improving the treatment outcome in Pulmonary TB patients. <strong>Conclusion:</strong> Pulmonary TB is associated with significant nutritional abnormalities. The findings of the study point to the fact that apart from BMI as the sole parameter for assessing the nutritional status in TB patients, there is a need to consider other anthropometric indices such as waist hip ratio, mid upper arm circumference, waist height ratio that can significantly correlate with the treatment outcome.</p>
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