821 research outputs found
Spectrum of skeletal abnormalities in a complex malformation syndrome with "cutis tricolor" (Ruggieri-Happle syndrome)
No full textBackground: The term cutis tricolor describes the combination of congenital hyper- and hypopigmented skin lesions in close proximity to each other in a background of normal complexion. This phenomenon has been reported: (i) as a purely cutaneous trait; (ii) as a part of a complex malformation syndrome (Ruggieri-Happle syndrome - RHS); (iii) as a distinct type [cutis tricolor parvimaculata]; (iv) in association with other (e.g. vascular) skin disturbances. Objectives: To delineate the spectrum of skeletal defects in cutis tricolor. Methods: Retrospective and prospective analysis of skeletal surveys in 14 subjects (eight men; six women; aged 2-28 years) with cutis tricolor [4 purely cutaneous trait; 10 syndromic (RHS)]. Results: Bone abnormalities were recorded in 71.4% (10/14) of patients [100% (10/10) of cases with (other-than-skeletal) extra-cutaneous manifestations vs. null (0/4) in cases with purely cutaneous traits] and included overall small skull (n = 6); prognathism (n = 6); 'J'-shaped pituitary fossa (n = 1); absence of atlas posterior arch (n = 3); frontal bossing (n = 6); scoliosis (n = 9) with kyphosis (n = 6) and/or lordosis (n = 6); vertebral (n = 9) and ribs (n = 4) defects. Negative ZFHX1B gene analyses excluded overlaps with Mowat-Wilson syndrome. Conclusions: Cutis tricolor may be a marker of underlying skeletal involvement particularly in subjects with a complex syndromic (RHS) phenotype. © 2010 The Author(s)/Acta Pædiatrica © 2010 Foundation Acta Pædiatrica
Cortical and subcortical brain alterations in Juvenile Absence Epilepsy
No full textDespite the common assumption that genetic generalized epilepsies are characterized by a macroscopically normal brain on magnetic resonance imaging, subtle structural brain alterations have been detected by advanced neuroimaging techniques in Childhood Absence Epilepsy syndrome. We applied quantitative structural MRI analysis to a group of adolescents and adults with Juvenile Absence Epilepsy (JAE) in order to investigate micro-structural brain changes using different brain measures. We examined grey matter volumes, cortical thickness, surface areas, and subcortical volumes in 24 patients with JAE compared to 24 healthy controls; whole-brain voxel-based morphometry (VBM) and Freesurfer analyses were used. When compared to healthy controls, patients revealed both grey matter volume and surface area reduction in bilateral frontal regions, anterior cingulate, and right mesial-temporal lobe. Correlation analysis with disease duration showed that longer disease was correlated with reduced surface area in right pre- and post-central gyrus. A possible effect of valproate treatment on brain structures was excluded. Our results indicate that subtle structural brain changes are detectable in JAE and are mainly located in anterior nodes of regions known to be crucial for awareness, attention and memory
Peer Attachment: A Meta-analytic Review of Gender and AgeDifferences and Associations with Parent Attachment
No full textIn adolescence, peers represent key actors within individual social network. Given the relevance of peer connections and the growing literature examining them, the purpose of this article was to review, through a meta-analytic approach, studies on adolescent and youth peer relationships within the theoretical framework of attachment. First, we synthesized results of 44 studies focused on relationships between parent and peer attachment. Second, we summarized findings of 54 studies reporting gender differences on peer attachment. Third, we computed an overall effect for age differences on peer attachment documented in 19 studies. Main findingshighlighted that parent attachment is moderately correlated to peer attachment; that females were significantly more attached to their peers than males; and that the correlation between age and peer attachment was not significant. This set of findings was confirmed examining both overall peer attachment as well as specific dimensions of attachment, such as trust and communication. Furthermore, since a significant heterogeneity was found across studies, we tested the effects of various categorical (i.e., year and language of publication, country, attachment measure) and continuous (i.e., mean age and percentage of females of the sample, number of items of the peer attachment scale) moderators related to characteristics of the study samples and designs. Implications of these findings for future research are discussed. A focus on cultural dimensions and on peer attachment processes would be worthwhile to address relevant research questions: How do peer relationships progressively become mature attachment relationships? How is this process shaped for individuals with different parent attachment histories
Peer attachment and self-esteem: A meta-analytic review
No full textPeer attachment might provide individuals with opportunities to build their sense of self-worth. The pur- pose of this paper was to meta-analytically review literature on peer attachment and self-esteem. A total of 22 articles reporting 24 studies documenting correlations between peer attachment and self-esteem in adolescents and emerging adults were included in this meta-analysis. Of these studies, most examined links between global peer attachment and self-esteem, while few studies reported any associations between specific dimensions of peer attachment (i.e., trust, communication, and alienation) and self- esteem. Results showed significant correlations between peer attachment and self-esteem, consistently found both in studies focused on global attachment as well as in studies including specific attachment dimensions. Furthermore, since a significant heterogeneity was found across the studies, the effects of various categorical and continuous moderators related to characteristics of the study samples and designs were tested. Implications of these findings for future research are discussed
Chemical interaction, space-charge layer, and molecule charging energy for a TiO2/TCNQ interface
No full textThree driving forces control the energy level alignment between transition-metal oxides and organic materials: the chemical interaction between the two materials, the organic electronegativity, and the possible space charge layer formed in the oxide. This is illustrated in this study by analyzing experimentally and theoretically a paradigmatic case, the TiO2(110)/TCNQ interface; due to the chemical interaction between the two materials, the organic electron affinity level is located below the Fermi energy of the n-doped TiO2. Then, one electron is transferred from the oxide to this level and a space charge layer is developed in the oxide, inducing an important increase in the interface dipole and in the oxide work function.Peer reviewe
Simmel Studies
No full textArticles published in Simmel Studies are original articles, not yet published or considered for publication elsewhere. Contributors may submit articles in English, German and French, and each article should be accompanied by a brief abstract (150 words) in English and the complete address of the author, including e-mail.
Simmel Studies is abstracted and indexed by Sociological Abstracts (SA). Social Planning/Policy & Development Abstracts (SOPODA), and Linguistics and Language Behaviour Abstracts (LLBA)
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