3,168 research outputs found
Ferreira, Ferrari: ficções do exílio
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2015.Esta é uma leitura dos exílios de Ferreira Gullar e León Ferrari, durante as últimas ditaduras militares que tomaram conta do Cone Sul, incluindo Brasil e Argentina. Entre 1971 e 1977, Gullar passou por Moscou, Santiago, Lima e Buenos Aires, além de outras cidades, enquanto Ferrari, por sua vez, estabeleceu-se com sua família em São Paulo do final de 1976 até 1984, sendo que após esse período ainda dividiria por alguns anos a sua permanência entre a capital paulista e Buenos Aires. Alguns de seus mais notáveis trabalhos foram realizados no exílio, de modo que a configuração de uma paisagem ou cena exílica torna-se indissociável das experiências conduzidas com a linguagem. Em poucas palavras: embora marcado pela tanatopolítica castrense e pelo nomos gestor do capital global, é possível afirmar que o exílio não está dado de antemão e nem permanece sempre o mesmo, quer seja como dano ou como dádiva; é somente com a linguagem  a imagem, o sensível  que uma experiência exílica, sempre singular e radicalmente contemporânea, pode encontrar a sua superfície de exposição, quer dizer, a sua diferença. Conquanto sejam profundamente dessemelhantes, os exílios de Ferreira Gullar e León Ferrari não deixam de mostrar afinidades, sobretudo nos momentos em que suas experiências tocam um ponto comum: o espaço  um topos  a-tópico da impropriedade, da potência, da in-operatividade que, com a linguagem, resiste indomesticável às tentativas de cristalização da língua, do povo, do poder, da nação. Foucault, Saer, Coccia e outros autores franqueiam um pensamento da ficção enquanto construção contingencial capaz de desnaturalizar os usos do discurso e a teleologia que assedia constantemente a literatura, as artes, a história. De certo modo, a ficção ¬repete, expõe e portanto difere as fábulas, ao mesmo tempo em que expõe e difere a si mesma. É essa operação in-operante, esse trabalho afirmativo da negatividade que suspende a maquinaria imunitária, autonomista, da civilização ocidental e cristã.Abstract : This is a reading of both Ferreira Gullar and León Ferrari s exiles, during the last military dictatorships that took account of the Southern Cone, including Brazil and Argentina. Between 1971 and 1977, Gullar went through Moscow, Santiago, Lima and Buenos Aires, and other cities, while Ferrari settled with his family in São Paulo from late 1976 until 1984, and thereafter still divided for a few years his stay between São Paulo and Buenos Aires. Some of his most notable works were carried out in exile, so that the configuration of an exilic landscape or scene becomes inseparable from experiments conducted with language. In short, although marked by military thanatopolitics and the nomos of global capital manager, it is possible to say that exile is not given in advance and not always remains the same, whether as damage or as a gift; it is only with the language  the image, the sensible  that an exilic experience, always singular and radically contemporary, can find its exposure surface, that is, its difference. While they are profoundly dissimilar, Ferreira Gullar and León Ferrari s exiles show their affinities, particularly at times when their experiences play a common point: the space  a topos  a-topic of the impropriety, potency, of in-operativity that, together with language, resists untamable against all crystallization attempts on the idiom, people, power, and nation. Foucault, Saer, Coccia and other authors frank a thought of fiction as a contingency construction able to denature the uses of speech and the teleology that constantly haunts literature, arts, and history. In a way, fiction repeats, exposes and therefore differs fables, while exposes and differs itself. It is this in-operative operation, this affirmative work of negativity that suspends the immunitary machinery of Christian Western civilization
Media-logica socratica. L’approccio dialogico-argomentativo alla mediazione alla prova di un case study
No full textIl contributo si compone di due parti.
Una prima, a cura di Federico Reggio, ripercorre alcuni profili metodologici della mediazione visti in relazione con l'argomentazione giuridica, alla luce di una prospettiva che enfatizza la mediazione come 'maieutica del dialogo'.
Segue una seconda parte, a cura di Anna Ferrari Aggradi, nella quale la prospettiva elaborata nella prima parte viene raffrontata con problemi e strategie emersi in un caso concreto di mediazione civile e commerciale, dagli intrecci complessi (e che lambiscono anche il diritto di famiglia)
Trattamento farmacologico integrato per la terapia delle tossicodipendenze
No full textLa tossicodipendenza e’ una condizione complessa per la quale e’ vano attendersi una soluzione unica, rapida e semplice. Possono o meglio devono coesistere piu’ soluzioni e piuttosto che sprecare tempo, energie e risorse per individuare quella migliore dovrebbe essere fatto ogni sforzo per definire indicazioni e limiti, vantaggi e svantaggi, benefici e rischi delle diverse metodologie di cui oggi disponiamo in modo da saper offrire, ad ogni paziente il trattamento per lui piu’ adeguato.
Infine e’ doveroso pur applicando procedure di disintossicazione standardizzate e consolidate tentare di ottimizzare il trattamento sulla base della storia clinica del singolo soggetto. Per ultimo bisogna ricordare che e’ necessario ottenere il consenso del paziente per qualsiasi tecnica venga applicata e non solo nel caso di sperimentazioni.
Nell’ambito del trattamento della dipendenza da oppiacei la disintossicazione viene considerata come una sorta di fase preparatoria agli interventi successivi, più’ a lungo termine che hanno lo scopo di costruire e consolidare nel tempo le risorse e le capacita’ necessarie al paziente per evitare o almeno ridurre al minimo le recidive. Oppure può’ aver luogo come fase, ultima, di un trattamento di mantenimento con farmaci agonisti (metadone, LAAM, buprenorfina). In questo caso il primo passo verso la riabilitazione e’ il trattamento di mantenimento
Concentrazioni plasmatiche di naltrexone e 6-beta-naltrexolo in soggetti in trattamento a lungo termine
No full textIl naltrexone e’ un farmaco completamente assorbito per via orale (Licko, 1980) (Perez-Reyes et al 1980) , varia pero’ la velocita’ di assorbimento in quanto il Tmax e’ compreso tra i 30 minuti e le 2 ore. E’ sottoposto ad un esteso first pass effect (Kogan et al., 1977) e buona parte del farmaco assorbito e’ convertito in diversi metaboliti (Meyer et al., 1984).
La percentuale della dose somministrata per via orale che raggiunge immodificata il circolo sistemico varia a seconda degli studi dal 5-6 (Meyer et al., 1984) al 20, 40 (Chiang C N et al, 1984) o 60% (Wall et al., 1981). Il Naltrexone e’ eliminato dal corpo primariamente per metabolismo epatico (liver metabolization) (Verebey et al., 1976) (Cone et al., 1974) (Dayton and Inturrisi, 1976); solo l’1% di una dose orale si ritrova invariata nelle urine. La tappa principale e’ la riduzione del keto gruppo a gruppo alcolico con la formazione del 6-b-naltrexolo (Cone 1973). Il 6-b-naltrexolo e’ un antagonista considerably weaker than naltrexone (da 1/15 Cone E J et al. 1974) - 1/26 - 1/53 della potenza del naltrexone negli animali (Blumberg and Ikeda, 1976) ma non ci sono dati nell’uomo (The potency ratio in humans is unknown). Da tutti gli studi effettuati i livelli ematici di questo metabolita variano notevolemente da un soggetto all’altro ma sono sempre risultati molto piu’ elevati di quelli del naltrexone e pertanto potrebbe contribuire alla durata del blocco dei narcotici. Sia il naltrexone che il 6-b-naltrexolo vengono poi estesamente glicuronoconiugati (glucuronic acid). Altri metaboliti di minore importanza sono il 2-hydroxy- 3-O-methyl naltrexone e il 2-hydroxy-3-O-methyl-6b-naltrexol e forse i loro glicuronoconiugati. Vi è un'importante variazione interindividuale delle concentrazioni plasmatiche di naltrezone e di 6 -beta-naltrexolo. Proprio per queste differenze non è stato possibile individuare un range terapeutico ottimale
Impacts of Industry 5.0 Target Dimensions on the Performance of Intra-Logistics Systems: An Assessment Framework
No full textEven though there is a growing interest in Industry 5.0 (I5.0), holistic studies assessing the technologies and managerial approaches driving its adoption—especially regarding their impact on intralogistics systems—are lacking. Based on Design Research Methodology, this paper proposes a framework
to evaluate how technologies and approaches related to the three key dimensions of I5.0—human-centricity, resilience, and sustainability—affect the design and performance parameters of material handling, storage, and picking systems. Using methods like a Systematic Literature Review and expert surveys, the study pinpoints key technologies and approaches for I5.0, along with the primary factors influencing the design of intra-logistics systems and their operational and economic performance. An assessment framework has been developed relying on Domain Mapping Matrices. Further research will include a Delphi study with industrial experts to determine the most impactful I5.0 technologies and approaches on intra-logistics
systems. In such a way, guidelines for the development of these systems can be derived
INFLUENCE OF PROLONGED THERAPY WITH FLUNARIZINE ON GLUCOSE, INSULIN AND C-PEPTIDE METABOLISM
No full textThe use of flunarizine in the preventive treatment of headaches and migraine is now widely done. Taking into account that the main and more frequent side effects of this treatment are weight gain and increase of appetite, with a typical carbohydrates craving, we studied the influence of a prolonged treatment of flunarizine on glucose, C- peptide and insulin metabolism in headache sufferers.
All these substances were studied before and after treatment and we did not find significant differences after the treatment. So we could conclude that this drug even if increases appetite , does not interfere with glucose metabolism and it is possible to hypothesize that the carbohydrate craving could be related to a facilitate income of glucose into the cell
The role of Phytochelatin Synthase in the microalga Scenedesmus acutus M. (Sphaeropleales).
No full textThe role of Phytochelatin Synthase in the microalga Scenedesmus acutus M. (Sphaeropleales)
M. Ferrari, R. Cozza, M. Marieschi, R. Ruotolo, A. Torelli
Phytochelatins (PCs) are small cysteine-rich peptides that are not genetically encoded but are synthesized by Phytochelatin Synthase (PCS) in the presence of glutathione as substrate. The constitutive expression of PCS and the presence of homologues of the PCS gene(s) in plants growing in ecosystems geographically remote from metal-contaminated sites, as well as in representatives of various kingdoms of living organisms, suggest that PCS has a wide range of different functions (Clemens et al. 2009). However, the main function of PCs in plants is to immobilize, sequester, and detoxify metal ions (Shukla et al. 2013). The effect of metals on the activity of PCS can differ not only between species, but also between different isoforms of the enzyme within a species.
Although it is evident that chromium (Cr) ions can stimulate the formation of PCs in plants (Yu et al. 2018), there is no information on their presence in algae in response to Cr exposure.
In this study, two strains of the green alga Scenedesmus acutus with different Cr(VI) sensitivity, namely the wild type (wt) and the chromium-tolerant strain (Cr-t), were selected as a model algal species to increase the knowledge on the role of PCs in Cr responses in microalgae.
We previously reported the first evidence for a PCS gene (SaPCS) from the microalga S. acutus. More recently, we have also identified two SaPCS isoforms due to a putative alternative splicing.
To define the role of PCS in Cr detoxification, we analyzed the levels of SaPCS transcription, and the abundance of PCS by using RT-qPCR and Western blot, respectively, in both strains of S. acutus after 24h culture in standard and in Cr supplemented medium (1 and 2 mg Cr (VI)/l).
Given the relationship between sulfur (S) metabolism and Cr(VI) tolerance in S. acutus (Sardella et al. 2019), we also performed the same analyses in S-replete cells of both strains after medium renewal following S-starvation.
The results showed a different behavior between strains in the stress response. RT-qPCR analysis revealed an increase in SaPCS transcription after Cr(VI) stress and after medium renewal following S-starvation in wt cells. Instead, the Cr-t strain induced SaPCS transcription only under S-replete conditions.
Western blot analysis, performed with a polyclonal antibody raised against PCS of Arabidopsis thaliana, revealed an immunoreaction signal on two proteins with molecular weights of approximately 73 and 37 kDa. While the abundance of the 73 kDa protein did not change after the stresses studied in the two strains, the 37 kDa protein increased after S-starvation in both strains but in a significant manner only in wt.
Finally, a preliminary quantification of PC production was performed, through LC Mass analysis in the two strains in preculture with or without S and under 1 mg Cr(VI)/l, which showed no modulation of PC abundance in response to Cr(VI) stress and/or S deprivation. Nevertheless, the Cr-t strain maintained PCs level significantly higher than the wt at the end of S-starvation.
These observations suggest that PCS in S. acutus may not be involved in Cr(VI) detoxification, but may play a role in intracellular sulfur balance or in the cell homeostasis during stress.
The PC production in the other experimental conditions (i.e. exposures longer than those studied and different Cr(VI) concentrations) should be investigated to better clarify the role of the enzyme in Cr(VI) detoxification.
Letteratura citata
Shukla D., Tiwari M., Tripathi E.D., Nath P., Trivedi P.K. (2013). Synthetic phytochelatins complement a phytochelatin-deficient Arabidopsis mutant and enhance the accumulation of heavy metal(loid)s. Biochem Biophy Res Commun 434:664–669
Clemens S., Peršoh D. (2009). Multi-tasking phytochelatin synthases. Plant Sci., 177, 266–271.
Yu, X.Z., Ling, Q.L., Li, Y.H., Lin Y.J. (2018) mRNA Analysis of Genes Encoded with Phytochelatin Synthase (PCS) in Rice Seedlings Exposed to Chromium: The Role of Phytochelatins in Cr Detoxification. Bull Environ Contam Toxicol 101, 257–261.
Sardella A., Marieschi M., Mercatali I., Zanni C., Gorbi G., Torelli A. (2019). The relationship between sulfur metabolism and tolerance of hexavalent chromium in Scenedesmus acutus (Spheropleales): Role of ATP sulfurylase. Aquatic Toxicology, 216:105320.
AUTORI
Michele Ferrari ([email protected]), Radiana Cozza, Department of Biology, Ecology and Earth Science, University of Calabria, Via P. Bucci, 87036 Rende (CS).
Matteo Marieschi, Roberta Ruotolo, Anna Torelli, Department of Life Sciences, University of Parma, Parco Area delle Scienze 11/A, 43124 Parm
Vanadium doping in CaO-ZrO2-SiO2 glasses
No full textStructural and colour changes induced by increasing amounts of vanadium oxide. V2O5, are presented for a near formulation of glass with composition 37CaO, 6ZrO(2), 57SiO(2) (mol%). Property changes were evaluated by measuring density, chemical durability and microhardness of glasses with increasing amount of vanadium oxide. Vanadium oxide imparts to tire glass a light green colour, not dissimilar to that from chromium, at low content, while at higher concentration the colour changes to dark brown. Spectroscopic technique, VIS-NIR and ESR were rued to identify tire chromophore centres in terms of vanadium oxidation state and coordination which there subsequently correlated to property changes. Experimental evidence is reported for an equilibrium between two species. V5+-tetrahedral and V4+ tetragonally distorted octahedral
Naltrexone: a post-marketing surveillance study
No full textSince 1985 we have been evaluating the side effects of chronically administered naltrexone in heroin addicts. To date the study includes 91 patients. The side-effects were the following: protracted abstinence, 41%, headache 29%, less appetite 27% of the patients
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