4,101 research outputs found

    sj-jpeg-2-jcn-10.1177_08830738231169411 - Supplemental material for Neuroimaging Findings in Vitamin B<sub>12</sub>-Deficient Infants With Neurologic Features

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    Supplemental material, sj-jpeg-2-jcn-10.1177_08830738231169411 for Neuroimaging Findings in Vitamin B12-Deficient Infants With Neurologic Features by Anjali Yadav, Chandrika Azad, Ravinder Kaur, Vishal Guglani, Seema Gupta and Sukanya Mitra in Journal of Child Neurology</p

    sj-png-3-jcn-10.1177_08830738231169411 - Supplemental material for Neuroimaging Findings in Vitamin B<sub>12</sub>-Deficient Infants With Neurologic Features

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    Supplemental material, sj-png-3-jcn-10.1177_08830738231169411 for Neuroimaging Findings in Vitamin B12-Deficient Infants With Neurologic Features by Anjali Yadav, Chandrika Azad, Ravinder Kaur, Vishal Guglani, Seema Gupta and Sukanya Mitra in Journal of Child Neurology</p

    sj-docx-1-jcn-10.1177_08830738231169411 - Supplemental material for Neuroimaging Findings in Vitamin B<sub>12</sub>-Deficient Infants With Neurologic Features

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    Supplemental material, sj-docx-1-jcn-10.1177_08830738231169411 for Neuroimaging Findings in Vitamin B12-Deficient Infants With Neurologic Features by Anjali Yadav, Chandrika Azad, Ravinder Kaur, Vishal Guglani, Seema Gupta and Sukanya Mitra in Journal of Child Neurology</p

    The disordered plant dehydrin Lti30 protects the membrane during water-related stress by cross-linking lipids

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    Dehydrins are intrinsically disordered proteins, generally expressed in plants as a response to embryogenesis and waterrelated stress. Their suggested functions are in membrane stabilization and cell protection. All dehydrins contain at least one copy of the highly conserved K-segment, proposed to be a membrane- binding motif. The dehydrin Lti30 (Arabidopsis thaliana) is up-regulated during cold and drought stress conditions and comprises six K-segments, each with two adjacent histidines. Lti30 interacts with the membrane electrostatically via pH-dependent protonation of the histidines. In this work, we seek a molecular understanding of the membrane interaction mechanism of Lti30 by determining the diffusion and molecular organization of Lti30 on model membrane systems by imaging total internal reflection- fluorescence correlation spectroscopy (ITIR-FCS) and molecular dynamics (MD) simulations. The dependence of the diffusion coefficient explored by ITIR-FCS together withMDsimulations yields insights into Lti30 binding, domain partitioning, and aggregation. The effect of Lti30 on membrane lipid diffusion was studied on fluorescently labeled supported lipid bilayers of different lipid compositions at mechanistically important pH conditions. In parallel, we compared the mode of diffusion for short individual K-segment peptides. The results indicate that Lti30 binds the lipid bilayer via electrostatics, which restricts the mobility of lipids and bound protein molecules. At low pH, Lti30 binding induced lipid microdomain formation as well as protein aggregation, which could be correlated with one another. Moreover, at physiological pH, Lti30 forms nanoscale aggregates when proximal to the membrane suggesting that Lti30 may protect the cell by "cross-linking" the membrane lipids.</p

    Data for Gupta et al., "Estimating the Meridional Extent of Adiabatic Mixing in the Stratosphere using Age-of-Air", JGR:Atmospheres,

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    Model data and post-processed data supporting the creation of the manuscript "Estimating the Meridional Extent of Adiabatic Mixing in the Stratosphere using Age-of-Air" submitted to JGR:Atmospheres in August 2022. 1) The netCDF files created through post-processing of full model data in FORTRAN are shared in the /data/ directory. These file contains the zonal mean circulation statistics based on Gupta et al. (2020), age-of-air transport diagnostics based on Linz et al. (2021), and the novel \Gamma-\Theta circulation streamfunction introduced in this study. The /data/ directory also contains MATLAB .mat data files for the transport diagnostics obtained from WACCM. 150 days of actual GFDL-FV3 model data in the northern hemisphere, between 0.1 hPa-500 hPa pressure levels is also provided to support external computations and validation. 2) The Jupyter notebook used for final computation and figures production is provided in .ipynb, .html and .pdf formats in /code/. All the files referred to in the notebook are stored in the /data/ directory. Corresponding author : Aman Gupta, [email protected], [email protected], [email protected]

    Corrigendum: Capital Inflows and House Prices: Aggregate and Regional Evidence from China

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    In the paper ‘Capital Inflows and House Prices: Aggregate and Regional Evidence from China’ by H. An, et al., printed in the December 2016 issue, there was a missing acknowledgement section for funding resources. On page 451, the acknowledgement section should appear after the corresponding information as: “Correspondence: Rakesh Gupta, Department of Accounting, Finance and Economics, Griffith Business School, Griffith University, Nathan Campus QLD 4111. [email protected] *This work was financially supported by the Humanities and Social Science Foundation of Ministry of Education of China (16YJA790001).” The author apologises for this error and any confusion it may have caused.No Full Tex

    E-store management using bell-lapadula access control security model

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    Generally, the existing store management system does not provide any access control mechanism in order to manage resources. All levels of user have the same right to access the store and borrow the equipment. Therefore, the E-Store management system using Bell- LaPadula access control model was proposed. The prototyping methodology was used to develop the system because methodology model is quickly constructed to test or illustrate design features and ideas, in order to gather user feedback. Moreover, the system is built using hypertext processor (PHP) language. The E-Store system has three types of users, which are known as top management of Welding Department, lecturers and students. The user’s access control is divided by high-level privilege to lower-level privilege. Therefore, each user will have different login interface according to their role and access right to the system. Through the system, high-level user manages in and out equipment flow, manages authorization, view history log in activity and verify complaint report. Lower-level user can view list of equipment, report complaint and damage equipment and borrow equipment. The E-Store management system is expected to manage the store effectively and reduced redundancy issues of equipment requested. The user access right has been assigned based on their access leve

    Efficient routing for P2P systems

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    Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.Includes bibliographical references (p. 51-55).This thesis examines the problem of locating and accessing an item stored in a large and volatile peer-to-peer system, and presents new ways of organizing items and peers to make this operation fast and efficient. Current structured peer-to-peer routing schemes keep routing information about only a small number of peers in the system, typically logarithmic in the size of the system. They do this under the assumption that it is infeasible to keep more routing information up-to-date since the system is highly volatile. As a result, when a node wants to locate an item, several peers have to be contacted in sequence before enough information is available to determine the location of the item. This makes routing a very long operation. In this thesis, we question this assumption and present two fast peer-to-peer routing algorithms. First, we present a "one hop" routing scheme. We show how to disseminate information about membership changes quickly enough so that peers maintain accurate routing tables with information about all peers in the system. Further, we demonstrate the feasibility of the system with analytical results and simulations. Second, we propose a "two hop" routing scheme for large scale systems of more than a few million peers, where the bandwidth requirements of one hop routing can become too large. This scheme keeps a fixed fraction of the total routing state on each peer, chosen such that the additional delay of routing is minimal.by Anjali Gupta.S.M

    First person – Akash Gupta

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    First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Akash Gupta is first author on ‘A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture’, published in BiO. Akash conducted the research described in this article while a PhD Scholar in Rajendra Mehta's lab at IIT Research Institute, Chicago, USA. He is now an assistant research scientist in the lab of Syreeta L. Tilghman at the University of Arizona, Department of Medicine, Tucson, USA, investigating drug efficacy modeling using human organoids culture for the treatment of cancers
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