1,721,972 research outputs found
Il 'Mito di Aracne' e la nobiltà della pittura. Breve incursione nella biblioteca di Velazquez
No full textArticolo che individua la fonte per l'iconografia della tela del Mito di Aracne di Velazquez nel Museo del Prado nell'edizione italiana delleMetamorfosi di Ovidio curata da Ludovico Dolce, della quale l'artista conservava una copia nella propria biblioteca
Voriconazole: Pharmacokinetics, role in therapeutic drug monitoring and clinical outcomes
No full textIn the last twenty years, the incidence of invasive fungal infections (IFI) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections and due to the increase of infection associated with travel. Moreover IFI in infants admitted to the neonatal intensive care unit are common and often fatal. Amphotericin B was for more than 40 years the gold standard for almost all IFI, but toxicity and resistance, especially of new and emerging pathogens remained important issues. Fluconazole and itraconazole have also the same disadvantage of resistance. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced as important agents in the treatment and prevention of IFI. These represent small or large advantages and differences compared with existing available alternative therapy for deep and systemic mycoses. Voriconazole is a second-generation triazole antifungal drug, often prescribed as first-line therapy for candidemia, in non-neutropenic hosts, for invasive pulmonary aspergillosis and as prophylaxis of many systemic mycoses. In-vitro and in-vivo studies showed that voriconazole has broad-spectrum activity against most Candida species, Aspergillus species, fusariosis or scedosporiosis. Voriconazole has non-linear pharmacokinetics and, as substrate and inhibitor of cytochrome P450, it undergoes extensive hepatic metabolism that depends on age, genetic factors, and interactions with other drugs, which may lead to enhanced toxicity of the concomitant medication(s) or ineffective antifungal treatment. This book presents an update on voriconazole research, particularly its pharmacology, microbiology, toxicology, and clinical outcomes in order to optimize its use in daily clinical practice
Artists and Gamblers on the Way to Quantum Physics
No full textThe representation space of Renaissance painting is compared to the representation space of quantum physics in [this chapter]. The action of a “semi-transparent” mirror splitting the trajectory of a photon, or any quantum particle, resembles the action of “Alberti’s window” in painting. According to Alberti, painting must recreate a view through a window. To accomplish this task, the light coming from the scene (to be painted) must be caught by the painter’s eye and projected on the plane surface of an ideal veil. The pictorial image results from a “double projection,” for that window acts both as a glass intersecting the visual pyramid and as a mirror reflecting the painter’s eye. When Narcissus realizes how a mirror acts, the shadow which he observes allows him to see another side of himself. When physicists realize how quantum interference acts, “photon-shadows” become “observables.” The awareness shared by Narcissus, Renaissance perspectivists, and quantum observers involves a revision of the function of shadow with respect to the Platonic condemnation and to the “fantastic” conception of the classic world. In the girl’s attempt to fix her lover’s image (told by Pliny), one can already see a “measuring her self against the other” that Plato’s myth had not envisaged. Despite the separation from the young man, the image she drew, the “artificial” representation, would maintain the link (of her self) with the “other.” This view of painting giving shape to “relational” forms marks itself off from a view of science describing “objective” properties of physical reality, hence losing or denying any link between the scientist-observer and the observed object
Positive interactions in salt marsh conservation
No full textContains fulltext :
219667.pdf (Publisher’s version ) (Open Access)Radboud University, 01 juli 2020Promotores : Lamers, L.P.M., Heide, Tjisse van der Co-promotor : Angelini, A.176 p
Resonant evanescent complex fields on dielectric multilayers
Full text linkComplex light fields, including evanescent Bessel beams, can be generated at dielectric interfaces by means of oil-immersion optics operating in total internal reflection conditions. Here we report on the observation of evanescent complex fields produced on a dielectric multilayer through the interference of surface modes resonantly sustained by the multilayer itself. The coupling to surface modes is attained by modifying the wavefront of an incident laser beam in such a way that the resulting intensity distribution in k-space matches the dispersion of the surface mode. The phase of surface modes can be further controlled, and two-dimensional vortex beams can also be produced according to the same working principle. (C) 2015 Optical Society of Americ
Dilated cardiomyopathy and myocarditis: classification, pathological, clinical and autoimmune features.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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