118 research outputs found
Haus in der Heimat: Lesebuch für die Volksschulen in Baden-Württemberg: Drittes Schuljahr
No full textHere is a typical third-grade reader from Germany in the 1950's. It contains a wealth of stories with colored and monochrome illustrations. I find three fables grouped together. LM, TB, and FC. TB is told in the version by Wilhelm Curtmann. The other two are attributed to Aesop. Only TB gets an illustration, but that a good monochrome depiction of the friend up a tree (102). By comparison with the art in the second-grade reader, "Von Frühling zu Frühling," this art is more typical of what I found in Germany in the 60's. The publishers seem to be a consortium of three in three cities: Gemeinschaftsverag: Badenia-Verlag; Paul Christian Lehrmittelverlag; and Union Verlag.Here is a typical third-grade reader from Germany in the 1950's. It contains a wealth of stories with colored and monochrome illustrations. I find three fables grouped together. LM, TB, and FC. TB is told in the version by Wilhelm Curtmann. The other two are attributed to Aesop. Only TB gets an illustration, but that a good monochrome depiction of the friend up a tree (102). By comparison with the art in the second-grade reader, "Von Frühling zu Frühling," this art is more typical of what I found in Germany in the 60's. The publishers seem to be a consortium of three in three cities: Gemeinschaftsverag: Badenia-Verlag; Paul Christian Lehrmittelverlag; and Union Verlag.This is a hardbound book (hard cover)This is a hardbound book (hard cover)Language note: GermanLanguage note: GermanZweite AuflageZweite AuflageBilder und Zeichnungen von Nikolaus PlumpBilder und Zeichnungen von Nikolaus Plum
Confluence up to garbage in graph transformation
No full text\ua9 2021 The Author(s)The transformation of graphs and graph-like structures is ubiquitous in computer science. When a system is described by graph-transformation rules, it is often desirable that the rules are both terminating and confluent so that rule applications in an arbitrary order produce unique resulting graphs. However, there are application scenarios where the rules are not globally confluent but confluent on a subclass of graphs that are of interest. In other words, non-resolvable conflicts can only occur on graphs that are considered as “garbage”. In this paper, we introduce the notion of confluence up to garbage and generalise Plump\u27s critical pair lemma for double-pushout graph transformation, providing a sufficient condition for confluence up to garbage by non-garbage critical pair analysis. We apply our results in two case studies about efficient language recognition: we present backtracking-free graph reduction systems which recognise a class of flow diagrams and a class of labelled series-parallel graphs, respectively. Both systems are non-confluent but confluent up to garbage. We also give a critical pair condition for subcommutativity up to garbage which, together with closedness, implies confluence up to garbage even in non-terminating systems
Valentine. Valentine Greetings
No full textA plump blue-eyed girl in a green coat, white hat, and a white muff. Text: Valentine Greetings. Date is approximate.https://egrove.olemiss.edu/romance_revelry/1012/thumbnail.jp
Andrew Jackson’s Cronies in Florida Territorial Politics
No full textIn Pensacola, an ancient Spanish village but then the boomtown capital of West Florida, the fifth day of October, 1821, was greeted with an unusual air of excitement. Along Palafox and Zaragoza streets, named long since for the Spanish hero General Palafox because of his heroic defense of Zaragoza, curious townsfolk gathered in gossiping knots around the Government House and public market, both fronting on Plaza Ferdinand VII. In Austin’s Tavern, the servants clearing away the remains of the great farewell party of the previous night, must have furtively gathered around the windows and peered expectantly into the street. Each horse and wagon momentarily distracted every man from his work or his conversation. At length the curiosity of everyone was rewarded by the appearance of a handsome horse-drawn carriage which pulled away from the Governor’s residence, crossed the Plaza and headed north through sandy Palafox street. Inside the carriage could be glimpsed the stern gray visage of Governor Andrew Jackson and the plump plain face of his wife Rachel
Studies on regeneration in the cerebral hemispheres of adult Triturus viridescens after unilateral incision, 1959
No full textA denaturing of the non- places: The redefinition of the urban voids of the escalator area in Hong Kong
No full textThe city produces spaces that could be termed as voids, due to a momentum of a design which tends to fill with clear functions and meanings each corner of it. As the city develops, within the limits of it appear as an integral part, spaces that lack of a clear role. Their meaning is continuously open to the formulation and often emerges "randomly" from the event of occasional events. What may make the acceptance of the void as a key element in an urban structure and under what conditions this (urban space) can be determined? The absence of a building in an area of the city is not enough for giving him the concept of 'urban void'. Spaces that can be characterized by a specific function or they serve an aesthetic point of view, and particularly in any case characterized by contents of the "filled" with interesting or indifferent actions of everyday life within cannot be defined as urban voids. Instead it could be seen to what extent, and even buildings are urban voids in conditions devoid of above characteristics. The voids are derivatives of unforeseeable transformations of the city. Their presence creates strange feelings. It could be seen as a reaction to the body of the city or a collateral development. So, which is the aesthetic perception of the urban voids of the escalator area? What defines them as voids? They are places? Or non- places? Do they have potentials to be filled with a specific function and which is the best solution? To be an integral part of the city or a parasitical formation of spaces? The site of the escalators is a mosaic of non-places, a mixture of different micro worlds with an escalator system to penetrate them and automatically define them as a performance. People who travel with the escalators are the viewers of the performance. Those who use the micro worlds, the performers, experience the semi-private spaces. But what exactly is the role of public space in this area? How can we re-define the new Hong Kongian public space under the new conditions of neo-liberalism? Which is the part of these urban voids inside this interrogation and redefinition of the public space? In conclusion, how we should treat these urban voids in order to serve the new re-defined feeling of Hong Kong? Goal The purpose of this project is to re- question and to re- defines the urban feeling of the Hong Kong through the re- formation of the urban voids of the escalators- area.dsd. architecture thinkingArchitectureArchitectur
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
No full textThe QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
Identifying and Validating New Drug Targets for Stroke and Beyond
No full textUntil very recently, drug discovery attrition rates have been increasing.1 This poor return on investment in biopharmaceutical research and development can be explained by scientific and extrascientific influences. Regulatory, payer, and commercial forces incentivized pharmaceutical companies to focus on common diseases and incremental improvements on existing mechanisms. The majority of resources within pharmaceutical companies have traditionally been focused on small-molecule drug discovery programs, reflecting a “hammer and a nail” mindset, with small-molecule chemistry as the hammer and the nail a classically defined “druggable” target. Rather than starting with a target based on strong human biological rationale, targets have been selected based on their ability to be “drugged” by a medicinal chemist. Compounding this problem has been an inadequate understanding of disease biology and an overreliance on animal models of human disease
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