5,080 research outputs found
Dwight D. Eisenhower to Dillon Anderson, November 10, 1956
No full textEisenhower expresses his appreciation of Anderson's supportTHE WHITE HOUSE
WASHINGTON
November 10, 1956
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Studies investigating peripheral blood derived cells that express the high affinity receptor for immunoglobulin E (Fc?RI) In Allergic Disorders
No full textIt is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for allergen induced immediate hypersensitivity reactions. IgE exerts its biological actions through the binding of its Fc fragment to specific Fc receptors on effector cells. There are two predominant Fc receptors for IgE – Fc?RI, which has a very high affinity for IgE and Fc?RII, which shows less avid binding. For much of the first two decades after the identification of IgE, it was thought that Fc?RI expression was limited to mast cells and basophils and that IgE binding to other cell types such as Blymphocytes and antigen presenting cells (APCs) was mainly due to Fc?RII. However with major advances in characterisation and functional knowledge of Fc?RI, particularly in the last fifteen years, it has become apparent that Fc?RI can be expressed on several more cell types that may be involved in initiation and maintenance of allergic inflammation – including APCs (monocytes and dendritic cells)and possibly eosinophils.The research described in the four papers forming this thesis was completed during this period and evaluated Fc?RI expression on different cell types, their potential roles in allergen induced inflammatory responses and whether successful therapeutic strategies for allergic disorders may involve actions on Fc?RI+ cells. The relative expression of Fc?RI on peripheral blood basophils, monocytes and eosinophils from atopic and non-atopic subjects and any relationship with serum IgE concentrations was assessed in the first paper. The second study examined a potentially important role for basophils as a cellular source of rapidly releasable IL-4 which may help initiate allergen induced TH2 responses. The next study investigated the possible effects on allergen induced early and late asthmatic responses of the immunosuppressive drug cyclosporin A which had been shown both to inhibit mast cell and basophil degranulation and cytokine secretion (particularly by CD4+ T-cells). The final study evaluated Fc?RI expression on these cell types as well humoral factors (e.g. seasonal changes in allergen specific IgG and IgE) in subjects who, after 3 to 4 years of grass pollen immunotherapy, had continued on either active or placebo immunotherapy for a further 3 years. A historical perspective explaining some of the reasons the studies were done is provided in the introductory chapter whilst the discussion chapter at the end reviews how many of the findings of the study have evolved in subsequent years right up to the present day and finishes off with a brief synopsis of how rapidly increasing knowledge of the regulatory functions of dendritic cells (expressing Fc?RI and often monocyte derived) has resulted in better understanding of the mechanisms of allergen specific immunotherapy and is leading to more effective treatment modalities
Dwight D. Eisenhower to Dillon Anderson, June 29, 1957
No full textEisenhower discusses importing crude oil as a possible national security threat and requests Anderson's assistence in investigating the situation'i.
THE WHITE HOUSE
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June 29, 1957
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On April twenty-third of this year, Gordon Gray, Director of the Office of Defense Mobilization, ad¬ vised nae, pursuant to Section 7 of the Trade Agreements Extension Act of 1955, that he had reason to believe that crude oil is being imported into the United States in such quantities as to threaten to impair the national security. As you know, I have established a special Cabinet Com¬ mittee to make an investigation to determine the facts in this matter.
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Since you have served as my Special Assistant for National Security Affairs, you are in an exceptionally favorable position to consult with me on the national security aspects of this problena.
I am delighted to know that you will make yourself available for such consultation during the time necessary for the completion of this task.
With warm personal regard.
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A subjetividade jurídica internacional na história da doutrina brasileira: oposições entre Nação e Estado nos séculos XIX e XX
No full textTCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.Com o objetivo de observar de que maneira a pergunta “quem é o sujeito de direitos na comunidade internacional” foi respondida, ressaltando as oposições entre Nação e Estado, o presente trabalho investigou o pensamento de Pasquale Stanislao Mancini, descrevendo como que, utilizando por fundamento do direito internacional o Princípio da Nacionalidade, o jurista italiano propõe a exclusividade da Nação como sujeito de direito internacional, em oposição ao Estado e de que maneira isto influenciou os autores da escola italiana de direito internacional, em especial Terenzio Mamiami e Pasquale Fiore. A seguir, adentra-se na doutrina brasileira da segunda metade do século XIX para verificar de que forma se deu a oposição entre os conceitos de Nação e Estado. Posteriormente, debruçando-se por sobre o pensamento de Lafayette Rodrigues Pereira e Clóvis Beviláqua, busca-se demonstrar como se tratou a problemática da subjetividade jurídica internacional no Brasil durante o início do século XX. Finalmente, verifica-se qual termo passou a ser adotado majoritariamente pela doutrina brasileira, até se encontrar um autor nacional que não mais defenda o exclusivismo de um ente político em específico, mas, consciente das diversas configurações históricas pelas quais passou a comunidade internacional, aceite uma pluralidade de sujeitos. Busca-se, ainda, ao longo de todo trabalho reforçar as continuidades e rupturas entre os diversos autores analisados, além de se proporem, quando cabíveis, críticas às concepções apresentadas.In order to observe how the question “who is the subject of rights in the international community” was answered, focusing on the contrasts between Nation and State, the present study investigated the thought of Pasquale Stanislao Mancini, describing how, using the Principle of Nationality as the basis of international law, the Italian jurist proposes the exclusivity of the Nation as a subject of international law in opposition to the State and how it influenced the authors of the Italian school of international law, especially Terenzio Mamiami and Pasquale Fiore. Hereafter, enter in the Brazilian doctrine of the second half of the nineteenth century to verify how occurred the opposition between the concepts of Nation and State. Posteriorly, looking at the thought of Lafayette Rodrigues Pereira and Clóvis Beviláqua, we seek to demonstrate how the problem of international juridical subjectivity was treated in Brazil during the early twentieth century. Finally, we verify which term was mostly adopted by Brazilian doctrine, until find a national author who no longer defends the exclusivity of a political entity in specific, but, aware of different historical settings of the international community, accepts a plurality of subjects. We also try throughout the study to highlight the continuities and changes between the various authors analyzed, and to propose, as appropriate, critical to the concepts presented
Studies investigating peripherial blood derived cells that express the high affinity receptor for immunoglobulin E (FceRI) in allergic disorders
No full textIt is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for
allergen induced immediate hypersensitivity reactions. IgE exerts its biological actions through the
binding of its Fc fragment to specific Fc receptors on effector cells. There are two predominant Fc
receptors for IgE – Fc?RI, which has a very high affinity for IgE and Fc?RII, which shows less avid
binding. For much of the first two decades after the identification of IgE, it was thought that Fc?RI
expression was limited to mast cells and basophils and that IgE binding to other cell types such as Blymphocytes
and antigen presenting cells (APCs) was mainly due to Fc?RII . However with major
advances in characterisation and functional knowledge of Fc?RI, particularly in the last fifteen years, it
has become apparent that Fc?RI can be expressed on several more cell types that may be involved in
initiation and maintenance of allergic inflammation – including APCs (monocytes and dendritic cells)
and possibly eosinophils.The research described in the four papers forming this thesis was completed during this period and
evaluated Fc?RI expression on different cell types, their potential roles in allergen induced
inflammatory responses and whether successful therapeutic strategies for allergic disorders may
involve actions on Fc?RI+ cells. The relative expression of Fc?RI on peripheral blood basophils,
monocytes and eosinophils from atopic and non-atopic subjects and any relationship with serum IgE
concentrations was assessed in the first paper. The second study examined a potentially important role
for basophils as a cellular source of rapidly releasable IL-4 which may help initiate allergen induced
TH2 responses. The next study investigated the possible effects on allergen induced early and late
asthmatic responses of the immunosuppressive drug cyclosporin A which had been shown both to
inhibit mast cell and basophil degranulation and cytokine secretion (particularly by CD4+ T-cells). The
final study evaluated Fc?RI expression on these cell types as well humoral factors (e.g. seasonal
changes in allergen specific IgG and IgE) in subjects who, after 3 to 4 years of grass pollen
immunotherapy, had continued on either active or placebo immunotherapy for a further 3 years.A historical perspective explaining some of the reasons the studies were done is provided in the
introductory chapter whilst the discussion chapter at the end reviews how many of the findings of the
study have evolved in subsequent years right up to the present day and finishes off with a brief
synopsis of how rapidly increasing knowledge of the regulatory functions of dendritic cells (expressing
Fc?RI and often monocyte derived) has resulted in better understanding of the mechanisms of allergen
specific immunotherapy and is leading to more effective treatment modalities
Cigarette smoking and its impact on the survival outcomes and molecular features of metastatic colorectal cancer patients
No full texthttps://openworks.mdanderson.org/sumexp22/1130/thumbnail.jp
The Role of Carcinogen Exposure in Colorectal Cancer Onset
No full texthttps://openworks.mdanderson.org/sumexp22/1120/thumbnail.jp
Table talk : being the discourses of John Selden. esq. Or his sense of various matters of weight and high consequence, relating especially to religion and state ...
No full textDedication signed: Ri. Milward
Supervision of DPD RI in The Implementation of Regional Autonomy
No full textIn a bicameral system, Regional Representative Council of Indonesia (Dewan Perwakilan Daerah Republik Indonesia/DPD RI) acts as a regional representative institution that fights for regional problems. The authority of DPD RI is to supervise implementation of the law. The supervisory functions of the DPD RI are to monitor and supervise the government and public institutions, including the implementation of laws, regulations and policies. In this study the authors used a qualitative approach. The purpose of this study is to see the extent of supervision carried out by DPD RI on the implementation of regional autonomy carried out by Committee I. The author used strategies, analysis and relevant and important sources related to the supervisory function of the DPD RI on the implementation of regional autonomy. The author found that the authority of supervision and follow-up of the results of DPD RI's supervision on the implementation of regional autonomy is still very limited, there are supervisory problems starting from the relationship between DPD RI and the central government and local governments, human resources and supporting resources are inadequate, and the level of public confidence in DPD RI decreases
Uncertainties in NDE Reliability and Assessing the Impact on RI-ISI
No full textA major thrust in the past 20 years has been to upgrade nondestructive examinations (NDE) for use in inservice inspection (ISI) programs to more effectively manage degradation at operating nuclear power plants. Risk-informed ISI (RI-ISI) is one of the outcomes of this work, and this approach relies heavily on the reliability of NDE, when properly applied, to detect sources of expected degradation. There have been a number of improvements in the reliability of NDE, specifically in ultrasonic testing (UT), through training of examiners, and improved equipment and procedure development. However, the most significant improvements in UT were derived by moving from prescriptive requirements to performance based requirements. Even with these substantial improvements, NDE contains significant uncertainties and RI-ISI programs need to address and accommodate this factor. As part of the work that PNNL is conducting for the U. S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, we are examining the impact of these uncertainties on the effectiveness of RI-ISI programs. One of the primary objectives of in-service inspection, including a RI-ISI program, is to manage potential degradation that may occur, but that had not been foreseen through previous operating experience. However, RI-ISI programs in the U.S are primarily based on history, looking back at past failures in the operating fleet. Therefore, RI-ISI may not adequately manage degradation events that are yet to occur, such as those that may have a long incubation (initiation) time, but a potentially fast growth rate. For this reason, RI-ISI will always be reactive to such failure events. Successful ISI needs to determine what NDE is required, when and how frequently it needs to be applied, how effective the NDE must be and where the NDE needs to be applied. Both flaw detection and accurate characterization need to be addressed. This paper will examine the reliability and uncertainties of NDE, and how these may impact RI-ISI.</jats:p
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